No Effect of High-Dose Vitamin D Supplementation on Glycemic Status or Cardiovascular Risk Factors in Subjects With Prediabetes
In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease. We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired...
Saved in:
| Published in | Diabetes care Vol. 37; no. 8; pp. 2123 - 2131 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria, VA
American Diabetes Association
01.08.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0149-5992 1935-5548 1935-5548 |
| DOI | 10.2337/dc14-0218 |
Cover
| Abstract | In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease.
We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year.
Mean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results.
This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT. |
|---|---|
| AbstractList | OBJECTIVE In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease. RESEARCH DESIGN AND METHODS We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year. RESULTS Mean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results. CONCLUSIONS This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT. In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease.OBJECTIVEIn observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease.We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year.RESEARCH DESIGN AND METHODSWe present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year.Mean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results.RESULTSMean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results.This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT.CONCLUSIONSThis study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT. In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease. We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year. Mean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results. This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT. In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease. We present 1-year data from an ongoing 5-year trial in 511 individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) randomly assigned to 20,000 IU/week vitamin D3 or placebo. An oral glucose tolerance test was performed at baseline and after 1 year. Mean baseline serum 25(OH)D was 59.9 nmol/L and 61.1 nmol/L in the vitamin D and placebo groups, respectively, and increased by 45.8 nmol/L and 3.4 nmol/L, respectively. With adjustment for baseline concentrations, no differences in measures of glucose metabolism, insulin secretion or sensitivity, blood pressure, or hs-CRP were found after 1 year. There was a slight, but significant decrease in total and LDL cholesterol in the vitamin D group compared with the placebo group, but as there was also a decrease in HDL cholesterol, the change in the total/HDL cholesterol ratio did not differ significantly. Only analyzing subjects with 25(OH)D <50 nmol/L did not change the results. This study shows that vitamin D supplementation does not improve glycemic indices, blood pressure, or lipid status in subjects with IFG and/or IGT. |
| Author | Figenschau, Yngve Fuskevåg, Ole M. Schirmer, Henrik Hutchinson, Moira Y.S. Njølstad, Inger Sollid, Stina Therese Joakimsen, Ragnar M. Kamycheva, Elena Jorde, Rolf Svartberg, Johan |
| Author_xml | – sequence: 1 givenname: Stina Therese surname: Sollid fullname: Sollid, Stina Therese organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway – sequence: 2 givenname: Moira Y.S. surname: Hutchinson fullname: Hutchinson, Moira Y.S. organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Rehabilitation Services, University Hospital of North Norway, Tromsø, Norway – sequence: 3 givenname: Ole M. surname: Fuskevåg fullname: Fuskevåg, Ole M. organization: Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway – sequence: 4 givenname: Yngve surname: Figenschau fullname: Figenschau, Yngve organization: Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway, Department of Medical Biology, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway – sequence: 5 givenname: Ragnar M. surname: Joakimsen fullname: Joakimsen, Ragnar M. organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway, Department of Clinical Medicine, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway – sequence: 6 givenname: Henrik surname: Schirmer fullname: Schirmer, Henrik organization: Department of Clinical Medicine, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway – sequence: 7 givenname: Inger surname: Njølstad fullname: Njølstad, Inger organization: Department of Community Medicine, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway – sequence: 8 givenname: Johan surname: Svartberg fullname: Svartberg, Johan organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway, Department of Clinical Medicine, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway – sequence: 9 givenname: Elena surname: Kamycheva fullname: Kamycheva, Elena organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway – sequence: 10 givenname: Rolf surname: Jorde fullname: Jorde, Rolf organization: Tromsø Endocrine Research Group, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway, Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway, Department of Clinical Medicine, The University of Tromsø - The Arctic University of Norway, Tromsø, Norway |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28691485$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24947792$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0kuLFDEQAOAgK-7s6ME_IAER9NBu0nkfZfYlLCqOj2OTTle7Gbs7Y5IW9uRfN-OMCosghATClypSVSfoaAoTIPSYkpc1Y-q0c5RXpKb6HlpQw0QlBNdHaEEoN5Uwpj5GJyltCCGca_0AHdfccKVMvUA_3gR83vfgMg49vvJfbqqzkAB_8tmOfsJneD1vtwOMMGWbfZhwWZfDrYPRO7wud3PCIeKVjZ0P321y82Ajfu_TV3xhXQ4x4RJmPbebkiPhzz7f4HcROm9byJAeovu9HRI8OpxL9PHi_MPqqrp-e_l69eq6ckzJXLXUgnTWGAa8Z7Kn1FlRk046IUApp5lkLQgjXecc00Q6CZaoXnKlNRWWLdHzfdxtDN9mSLkZfXIwDHaCMKeGSmIEpVLR_9NSXMkULdsSPb1DN2GOU_lIUYJQJqgWRT05qLkdoWu20Y823ja_u1DAswMo9bNDH-3kfPrrtDSU_wr0Yu9cDClF6P8QSprdJDS7SWh2k1Ds6R3r_L6DOVo__OPFT8Gzs5Y |
| CODEN | DICAD2 |
| CitedBy_id | crossref_primary_10_1080_23744235_2016_1201853 crossref_primary_10_1016_j_bone_2019_04_002 crossref_primary_10_1161_HYPERTENSIONAHA_115_05319 crossref_primary_10_12688_f1000research_24623_1 crossref_primary_10_12688_f1000research_24623_3 crossref_primary_10_3390_nu11030642 crossref_primary_10_12688_f1000research_24623_2 crossref_primary_10_3945_ajcn_116_132589 crossref_primary_10_1002_pdi_2072 crossref_primary_10_1371_journal_pone_0139244 crossref_primary_10_23736_S2724_5985_21_02955_7 crossref_primary_10_3390_nu16223936 crossref_primary_10_3390_nu13103491 crossref_primary_10_3390_nu12102990 crossref_primary_10_1136_bmjopen_2023_072087 crossref_primary_10_1093_nutrit_nux059 crossref_primary_10_1186_s12916_019_1401_y crossref_primary_10_5812_ircmj_41718 crossref_primary_10_1016_j_jns_2018_11_020 crossref_primary_10_1007_s00394_016_1159_3 crossref_primary_10_1111_dom_12625 crossref_primary_10_1038_s41430_020_00814_0 crossref_primary_10_1136_archdischild_2014_307961 crossref_primary_10_1007_s00223_019_00616_y crossref_primary_10_1007_s12603_020_1384_6 crossref_primary_10_1017_jns_2018_19 crossref_primary_10_1001_jamadermatol_2023_0357 crossref_primary_10_1007_s00774_024_01509_3 crossref_primary_10_1093_ajcn_nqz340 crossref_primary_10_1055_s_0042_1749117 crossref_primary_10_1186_s40795_020_00381_4 crossref_primary_10_1186_s12906_021_03474_0 crossref_primary_10_1016_j_cger_2015_04_004 crossref_primary_10_3390_nu15194223 crossref_primary_10_1097_MD_0000000000019034 crossref_primary_10_3390_nu9121280 crossref_primary_10_1016_j_bone_2020_115510 crossref_primary_10_3389_fcvm_2018_00087 crossref_primary_10_1371_journal_pone_0225600 crossref_primary_10_1210_js_2017_00472 crossref_primary_10_4158_EP14548_OR crossref_primary_10_1016_j_jsbmb_2017_01_015 crossref_primary_10_1530_EJE_14_0870 crossref_primary_10_1007_s00592_022_02001_y crossref_primary_10_1155_2018_7908764 crossref_primary_10_1016_j_redox_2016_10_007 crossref_primary_10_1016_j_jff_2018_10_040 crossref_primary_10_3945_ajcn_116_134981 crossref_primary_10_1186_s13063_016_1702_9 crossref_primary_10_1016_j_nutres_2022_12_005 crossref_primary_10_1210_jc_2015_4013 crossref_primary_10_1080_17512433_2022_2043153 crossref_primary_10_2337_dc19_1708 crossref_primary_10_1186_s13098_020_00549_9 crossref_primary_10_1001_jamainternmed_2015_0237 crossref_primary_10_1016_j_phrs_2021_105727 crossref_primary_10_3892_br_2018_1074 crossref_primary_10_1016_j_atherosclerosis_2016_05_019 crossref_primary_10_1007_s00198_017_4222_x crossref_primary_10_1038_s41598_017_15264_1 crossref_primary_10_3945_jn_117_254292 crossref_primary_10_1016_j_prostaglandins_2024_106883 crossref_primary_10_3389_fnut_2023_983515 crossref_primary_10_1016_j_numecd_2016_04_011 crossref_primary_10_1111_dme_12893 crossref_primary_10_5049_EBP_2017_15_1_1 crossref_primary_10_1038_s41598_019_56904_y crossref_primary_10_3390_foods10123065 crossref_primary_10_1161_JAHA_120_017727 crossref_primary_10_7759_cureus_36775 crossref_primary_10_1210_clinem_dgab402 crossref_primary_10_7759_cureus_75860 crossref_primary_10_1016_j_jsbmb_2017_03_016 crossref_primary_10_34883_PI_2020_2_2_040 crossref_primary_10_1038_ejcn_2017_67 crossref_primary_10_1038_srep16142 crossref_primary_10_1530_EC_18_0144 crossref_primary_10_2337_dc15_1057 crossref_primary_10_1016_j_cegh_2020_05_015 crossref_primary_10_1210_jc_2017_01187 crossref_primary_10_1093_ajcn_nqy078 crossref_primary_10_3390_nu16111561 crossref_primary_10_1016_j_jsbmb_2016_11_021 crossref_primary_10_3390_nu13124464 crossref_primary_10_1210_clinem_dgae312 crossref_primary_10_1530_EJE_15_1089 crossref_primary_10_15561_26649837_2023_0501 |
| Cites_doi | 10.1210/er.2012-1000 10.1038/ajh.2012.111 10.1136/bmj.323.7321.1123 10.1017/S0007114509992017 10.1007/s00204-013-1152-z 10.1111/j.1463-1326.2012.01605.x 10.1093/ije/dyr049 10.3945/jn.108.093831 10.1126/science.337.6101.1476 10.1210/jcem.85.7.6661 10.1056/NEJMoa1112082 10.2337/dc12-0962 10.1056/NEJM199807233390404 10.2337/diacare.20.4.537 10.1172/JCI0215219 10.2337/dc12-1204 10.1210/jc.2012-3720 10.1007/s00125-012-2801-0 10.1097/MNH.0b013e3283557bf0 10.1016/j.jsbmb.2004.03.115 10.2215/CJN.02980312 10.1056/NEJM200105033441801 10.1097/GME.0000000000000188 10.1038/ejcn.2011.118 10.1056/NEJMoa012512 10.2337/dc11-s221 10.1126/science.6250216 10.1210/jc.2007-0298 10.2337/diabetes.51.9.2796 10.1007/BF00280883 10.1161/HYPERTENSIONAHA.111.00659 10.1007/s11892-012-0358-4 10.1507/endocrj.47.383 10.1111/nure.12090 10.1016/j.amjcard.2010.05.027 10.1016/j.diabres.2011.10.029 10.3945/ajcn.112.050013 10.1016/j.plipres.2011.05.001 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Copyright American Diabetes Association Aug 2014 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. – notice: Copyright American Diabetes Association Aug 2014 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM K9. NAPCQ 7X8 ASE FPQ K6X |
| DOI | 10.2337/dc14-0218 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic British Nursing Index British Nursing Index (BNI) (1985 to Present) British Nursing Index |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic British Nursing Index |
| DatabaseTitleList | British Nursing Index MEDLINE - Academic MEDLINE ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1935-5548 |
| EndPage | 2131 |
| ExternalDocumentID | 3389842731 24947792 28691485 10_2337_dc14_0218 |
| Genre | Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article Feature |
| GroupedDBID | --- -ET ..I .XZ 08P 0R~ 18M 29F 2WC 4.4 53G 5GY 5RE 5RS 5VS 6PF 8R4 8R5 AAFWJ AAIKC AAKAS AAMNW AAWTL AAYEP AAYXX ABOCM ABPPZ ACGFO ACGOD ADBBV ADZCM AEGXH AENEX AERZD AFOSN AFRAH AHMBA AIAGR ALIPV ALMA_UNASSIGNED_HOLDINGS BAWUL BENPR BTFSW CITATION CS3 DIK DU5 E3Z EBS EDB EJD EMOBN EX3 F5P GX1 H13 HZ~ IAG IAO IEA IHR INH INR IOF IPO KQ8 L7B M0K M5~ O5R O5S O9- OK1 OVD P2P PCD Q2X RHI SV3 TDI TEORI TR2 TWZ VVN W8F WH7 WOQ WOW YHG YOC ~KM .55 .GJ 3O- 41~ 7RV 7X2 7X7 88E 88I 8AF 8AO 8C1 8F7 8FE 8FH 8FI 8FJ 8G5 AAQOH AAQQT AAYJJ ABUWG AFFNX AFKRA AI. AN0 AQUVI ATCPS AZQEC BCR BCU BEC BHPHI BKEYQ BKNYI BLC BNQBC BPHCQ BVXVI C1A CCPQU DWQXO FYUFA GNUQQ GUQSH HCIFZ HMCUK IQODW ITC J5H K9- M0R M0T M1P M2O M2P M2Q N4W NAPCQ PEA PHGZT PQQKQ PROAC PSQYO S0X SJFOW UKHRP VH1 WHG X7M ZCG ZGI ZXP CGR CUY CVF ECM EIF NPM PHGZM PJZUB PPXIY K9. 7X8 ASE FPQ K6X |
| ID | FETCH-LOGICAL-c376t-b1ae6ca993e4f36f11ca520d6c55e77c8363be596cdcc3806c6ea07f6478815a3 |
| ISSN | 0149-5992 1935-5548 |
| IngestDate | Fri Sep 05 04:11:58 EDT 2025 Thu Sep 04 23:27:10 EDT 2025 Mon Jun 30 16:50:50 EDT 2025 Mon Jul 21 06:01:47 EDT 2025 Wed Apr 02 07:25:26 EDT 2025 Thu Apr 24 23:10:33 EDT 2025 Tue Jul 01 04:11:40 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Human Nutrition Vitamin D Risk factor Cardiovascular risk Metabolic diseases Cardiovascular disease Supplementation High dose Endocrinology Glycemia |
| Language | English |
| License | CC BY 4.0 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c376t-b1ae6ca993e4f36f11ca520d6c55e77c8363be596cdcc3806c6ea07f6478815a3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 ObjectType-Article-2 |
| PMID | 24947792 |
| PQID | 1550135185 |
| PQPubID | 47715 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1609511671 proquest_miscellaneous_1548637186 proquest_journals_1550135185 pubmed_primary_24947792 pascalfrancis_primary_28691485 crossref_primary_10_2337_dc14_0218 crossref_citationtrail_10_2337_dc14_0218 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-08-01 |
| PublicationDateYYYYMMDD | 2014-08-01 |
| PublicationDate_xml | – month: 08 year: 2014 text: 2014-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Alexandria, VA |
| PublicationPlace_xml | – name: Alexandria, VA – name: United States – name: Alexandria |
| PublicationTitle | Diabetes care |
| PublicationTitleAlternate | Diabetes Care |
| PublicationYear | 2014 |
| Publisher | American Diabetes Association |
| Publisher_xml | – name: American Diabetes Association |
| References | Pan (2022031219454757100_B5) 1997; 20 Schnatz (2022031219454757100_B47) 2014 Pittas (2022031219454757100_B11) 2007; 92 Cheng (2022031219454757100_B32) 2013; 56 Melsom (2022031219454757100_B23) 2012; 7 2022031219454757100_B41 2022031219454757100_B40 2022031219454757100_B42 Vickers (2022031219454757100_B27) 2001; 323 Katz (2022031219454757100_B26) 2000; 85 Haffner (2022031219454757100_B2) 1998; 339 Belenchia (2022031219454757100_B18) 2013; 97 Tuomilehto (2022031219454757100_B6) 2001; 344 Mitri (2022031219454757100_B34) 2011; 65 Buchanan (2022031219454757100_B7) 2002; 51 Jacobsen (2022031219454757100_B20) 2012; 41 Bland (2022031219454757100_B29) 2004; 89-90 Kupferschmidt (2022031219454757100_B50) 2012; 337 Anderson (2022031219454757100_B15) 2010; 106 2022031219454757100_B19 Norman (2022031219454757100_B30) 1980; 209 Whiting (2022031219454757100_B1) 2011; 94 Heaney (2022031219454757100_B48) 2014; 72 Davidson (2022031219454757100_B39) 2013; 36 Forman (2022031219454757100_B45) 2013; 61 Li (2022031219454757100_B43) 2002; 110 2022031219454757100_B12 Pilz (2022031219454757100_B37) 2013; 13 Song (2022031219454757100_B16) 2013; 36 Harris (2022031219454757100_B38) 2012; 14 Carlsson (2022031219454757100_B8) 2012; 367 Wing (2022031219454757100_B10) 2010; 170 Rosen (2022031219454757100_B28) 2012; 33 Matthews (2022031219454757100_B25) 1985; 28 Pilz (2022031219454757100_B35) 2013; 87 DeFronzo (2022031219454757100_B9) 2011; 34 Liu (2022031219454757100_B13) 2009; 139 Jorde (2022031219454757100_B14) 2011; 50 2022031219454757100_B21 Knowler (2022031219454757100_B4) 2002; 346 2022031219454757100_B22 2022031219454757100_B24 Larsen (2022031219454757100_B46) 2012; 25 Gallagher (2022031219454757100_B49) 2012; 97 von Hurst (2022031219454757100_B17) 2010; 103 2022031219454757100_B3 Maestro (2022031219454757100_B31) 2000; 47 Tamez (2022031219454757100_B44) 2012; 21 2022031219454757100_B33 2022031219454757100_B36 |
| References_xml | – volume: 33 start-page: 456 year: 2012 ident: 2022031219454757100_B28 article-title: The nonskeletal effects of vitamin D: an Endocrine Society scientific statement publication-title: Endocr Rev doi: 10.1210/er.2012-1000 – volume: 25 start-page: 1215 year: 2012 ident: 2022031219454757100_B46 article-title: Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial publication-title: Am J Hypertens doi: 10.1038/ajh.2012.111 – volume: 323 start-page: 1123 year: 2001 ident: 2022031219454757100_B27 article-title: Statistics notes: analysing controlled trials with baseline and follow up measurements publication-title: BMJ doi: 10.1136/bmj.323.7321.1123 – volume: 103 start-page: 549 year: 2010 ident: 2022031219454757100_B17 article-title: Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial publication-title: Br J Nutr doi: 10.1017/S0007114509992017 – ident: 2022031219454757100_B33 – volume: 87 start-page: 2083 year: 2013 ident: 2022031219454757100_B35 article-title: The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? publication-title: Arch Toxicol doi: 10.1007/s00204-013-1152-z – volume: 14 start-page: 789 year: 2012 ident: 2022031219454757100_B38 article-title: A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2012.01605.x – volume: 41 start-page: 961 year: 2012 ident: 2022031219454757100_B20 article-title: Cohort profile: the Tromsø Study publication-title: Int J Epidemiol doi: 10.1093/ije/dyr049 – volume: 139 start-page: 329 year: 2009 ident: 2022031219454757100_B13 article-title: Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults publication-title: J Nutr doi: 10.3945/jn.108.093831 – ident: 2022031219454757100_B42 – volume: 337 start-page: 1476 year: 2012 ident: 2022031219454757100_B50 article-title: Uncertain verdict as vitamin D goes on trial publication-title: Science doi: 10.1126/science.337.6101.1476 – ident: 2022031219454757100_B3 – volume: 85 start-page: 2402 year: 2000 ident: 2022031219454757100_B26 article-title: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.85.7.6661 – volume: 367 start-page: 695 year: 2012 ident: 2022031219454757100_B8 article-title: Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects publication-title: N Engl J Med doi: 10.1056/NEJMoa1112082 – volume: 36 start-page: 1422 year: 2013 ident: 2022031219454757100_B16 article-title: Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies publication-title: Diabetes Care doi: 10.2337/dc12-0962 – volume: 339 start-page: 229 year: 1998 ident: 2022031219454757100_B2 article-title: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction publication-title: N Engl J Med doi: 10.1056/NEJM199807233390404 – volume: 20 start-page: 537 year: 1997 ident: 2022031219454757100_B5 article-title: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study publication-title: Diabetes Care doi: 10.2337/diacare.20.4.537 – volume: 110 start-page: 229 year: 2002 ident: 2022031219454757100_B43 article-title: 1,25-dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system publication-title: J Clin Invest doi: 10.1172/JCI0215219 – ident: 2022031219454757100_B19 – ident: 2022031219454757100_B36 – volume: 36 start-page: 260 year: 2013 ident: 2022031219454757100_B39 article-title: High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D publication-title: Diabetes Care doi: 10.2337/dc12-1204 – volume: 97 start-page: 4366 year: 2012 ident: 2022031219454757100_B49 article-title: Vitamin D deficiency and muscle strength: are they related? publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3720 – volume: 56 start-page: 553 year: 2013 ident: 2022031219454757100_B32 article-title: Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice publication-title: Diabetologia doi: 10.1007/s00125-012-2801-0 – ident: 2022031219454757100_B22 – volume: 21 start-page: 492 year: 2012 ident: 2022031219454757100_B44 article-title: Vitamin D and hypertension: an update and review publication-title: Curr Opin Nephrol Hypertens doi: 10.1097/MNH.0b013e3283557bf0 – volume: 89-90 start-page: 121 year: 2004 ident: 2022031219454757100_B29 article-title: Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2004.03.115 – volume: 7 start-page: 1801 year: 2012 ident: 2022031219454757100_B23 article-title: Physical exercise, fasting glucose, and renal hyperfiltration in the general population: the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6) publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.02980312 – volume: 344 start-page: 1343 year: 2001 ident: 2022031219454757100_B6 article-title: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance publication-title: N Engl J Med doi: 10.1056/NEJM200105033441801 – year: 2014 ident: 2022031219454757100_B47 article-title: Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women’s Health Initiative calcium/vitamin D randomized trial publication-title: Menopause doi: 10.1097/GME.0000000000000188 – volume: 65 start-page: 1005 year: 2011 ident: 2022031219454757100_B34 article-title: Vitamin D and type 2 diabetes: a systematic review publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2011.118 – volume: 346 start-page: 393 year: 2002 ident: 2022031219454757100_B4 article-title: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin publication-title: N Engl J Med doi: 10.1056/NEJMoa012512 – volume: 34 start-page: S202 year: 2011 ident: 2022031219454757100_B9 article-title: Type 2 diabetes can be prevented with early pharmacological intervention publication-title: Diabetes Care doi: 10.2337/dc11-s221 – volume: 209 start-page: 823 year: 1980 ident: 2022031219454757100_B30 article-title: Vitamin D deficiency inhibits pancreatic secretion of insulin publication-title: Science doi: 10.1126/science.6250216 – volume: 92 start-page: 2017 year: 2007 ident: 2022031219454757100_B11 article-title: The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-0298 – ident: 2022031219454757100_B12 – volume: 51 start-page: 2796 year: 2002 ident: 2022031219454757100_B7 article-title: Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women publication-title: Diabetes doi: 10.2337/diabetes.51.9.2796 – ident: 2022031219454757100_B40 – volume: 28 start-page: 412 year: 1985 ident: 2022031219454757100_B25 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 61 start-page: 779 year: 2013 ident: 2022031219454757100_B45 article-title: Effect of vitamin D supplementation on blood pressure in blacks publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.111.00659 – ident: 2022031219454757100_B21 – volume: 13 start-page: 261 year: 2013 ident: 2022031219454757100_B37 article-title: Role of vitamin D in the development of insulin resistance and type 2 diabetes publication-title: Curr Diab Rep doi: 10.1007/s11892-012-0358-4 – volume: 47 start-page: 383 year: 2000 ident: 2022031219454757100_B31 article-title: Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells publication-title: Endocr J doi: 10.1507/endocrj.47.383 – volume: 72 start-page: 48 year: 2014 ident: 2022031219454757100_B48 article-title: Guidelines for optimizing design and analysis of clinical studies of nutrient effects publication-title: Nutr Rev doi: 10.1111/nure.12090 – volume: 106 start-page: 963 year: 2010 ident: 2022031219454757100_B15 article-title: Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2010.05.027 – ident: 2022031219454757100_B24 – volume: 170 start-page: 1566 year: 2010 ident: 2022031219454757100_B10 article-title: Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial publication-title: Arch Intern Med – volume: 94 start-page: 311 year: 2011 ident: 2022031219454757100_B1 article-title: IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2011.10.029 – volume: 97 start-page: 774 year: 2013 ident: 2022031219454757100_B18 article-title: Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.3945/ajcn.112.050013 – ident: 2022031219454757100_B41 – volume: 50 start-page: 303 year: 2011 ident: 2022031219454757100_B14 article-title: Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids publication-title: Prog Lipid Res doi: 10.1016/j.plipres.2011.05.001 |
| SSID | ssj0004488 |
| Score | 2.4618077 |
| Snippet | In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for... OBJECTIVE In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors... |
| SourceID | proquest pubmed pascalfrancis crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 2123 |
| SubjectTerms | 25-Hydroxyvitamin D 2 - metabolism Adult Aged Aged, 80 and over Biological and medical sciences Blood pressure Blood Pressure - physiology Calcifediol - metabolism Cardiovascular disease Cholecalciferol - administration & dosage Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - prevention & control Diabetes. Impaired glucose tolerance Diabetic Angiopathies - prevention & control Dietary Supplements Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glucose Intolerance - prevention & control Glucose Tolerance Test Glycemic index Humans Insulin - metabolism Insulin resistance Insulin Resistance - physiology Lipids - blood Male Medical sciences Metabolic diseases Metabolism Middle Aged Prediabetic State - blood Prediabetic State - prevention & control Risk Factors Vitamin D Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D Deficiency - blood Vitamin D Deficiency - diet therapy Vitamins - administration & dosage Young Adult |
| Title | No Effect of High-Dose Vitamin D Supplementation on Glycemic Status or Cardiovascular Risk Factors in Subjects With Prediabetes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24947792 https://www.proquest.com/docview/1550135185 https://www.proquest.com/docview/1548637186 https://www.proquest.com/docview/1609511671 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKkBASQnxTGJNBPCBV6fJhO84jWpkGaAXBBuMpchwHFZVk6poHeOF_4i_kLnaStgw0kKqoSuw0yf16vrv87o6QpzxmicyF8LiKMo8pmXsq8zn-8ZgJCymDpjr_4VQcHLNXJ_xkMPi5wlqql9lYfz83r-R_pAr7QK6YJfsPku1OCjvgO8gXtiBh2F5IxtNq5KoPV5ax4U2Qfv4B_P2vs3I0GTU9Oy0_3FqGWELjm24I8Whm1g0ffW-dk_oO2eb7rg8PnAZ0y5eG8_ERY7ZvF6aN164atpM2hotUsi5sgxW_beB5OSsV0jsw26mH0hKZnC7n67CaLdTo0_j9uMNUfYaPBF_l80YjvZmDEuoPYyFRcM5V3awj5WebL9rGMALWMej6sGbi8cR2xRsbq4qTiHtg7MhVXW0LxDhMyjXFa9OW3SIeBnZt2VwgwqgpMZBrvIbQaf61Itwbi2NHWQRnCSenODXFqZfI5TAGew0N8Zev-1xc1vQ67e7IVrPCqbvdr67ZQNdOQbxqXtg-Kn92dBqD5-gGue48Ffrcwu4mGZjyFrly6LgYt8mPaUUt-mhV0A591KGPTugG-ih8WvRRiz5aLeg6-iiijzr0UThNiz6K6KMr6LtDjvdfHO0deK6dh6dhFVt6WaCM0AoMYsOKSBRBoBUP_Vxozk0caxmJKDM8ETrXOpK-0MIoPy4wG1oGoEvukq2yKs19Qv2cKc2FCWEIM0WSyUxJEefgLCvjJ9mQPGsfcKpdrXtsuTJPfxPjkDzphp7aAi_nDdpZk1I3MpQiCZjkQ7Ldii11CuIsRe8fG2Di4cfdYVDf-E5OlaaqcQyTIgIDUfxlDBaFxPelwZDcs5DoL4AlLI6T8MFFbuMhudr_-7bJ1nJRm0dgUy-znQbEvwDv5M1H |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=No+Effect+of+High-Dose+Vitamin+D+Supplementation+on+Glycemic+Status+or+Cardiovascular+Risk+Factors+in+Subjects+With+Prediabetes&rft.jtitle=Diabetes+care&rft.au=Sollid%2C+Stina+Therese&rft.au=Hutchinson%2C+Moira+Y.S.&rft.au=Fuskev%C3%A5g%2C+Ole+M.&rft.au=Figenschau%2C+Yngve&rft.date=2014-08-01&rft.issn=0149-5992&rft.eissn=1935-5548&rft.volume=37&rft.issue=8&rft.spage=2123&rft.epage=2131&rft_id=info:doi/10.2337%2Fdc14-0218&rft.externalDBID=n%2Fa&rft.externalDocID=10_2337_dc14_0218 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0149-5992&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0149-5992&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0149-5992&client=summon |