Inhibitory effects of arbutin on melanin biosynthesis of α-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish guinea pig skin tissues
Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; there...
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| Published in | Archives of pharmacal research Vol. 32; no. 3; pp. 367 - 373 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Pharmaceutical Society of Korea
01.03.2009
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 |
| DOI | 10.1007/s12272-009-1309-8 |
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| Abstract | Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with α-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of α-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening. |
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| AbstractList | Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with alpha-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of alpha-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening.Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with alpha-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of alpha-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening. Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with α-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of α-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening. Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with alpha-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of alpha-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening. Arbutin has been used as a whitening agent in cosmetic products. Melanin, the major pigment that gives color to skin, may be over-produced with sun exposure or in conditions such as melasma or hyperpigmentary diseases. Tyrosinase is a key enzyme that catalyzes melanin synthesis in melanocytes; therefore, inhibitors of the tyrosinase enzyme could be used for cosmetic skin whitening. A recent study has reported that arbutin decreases melanin biosynthesis through the inhibition of tyrosinase activity. However, this inhibitory mechanism of arbutin was not sufficiently demonstrated in skin tissue models. We found that arbutin both inhibits melanin production in B16 cells induced with α-MSH and decreases tyrosinase activity in a cell-free system. Furthermore, the hyperpigmentation effects of α-MSH were abrogated by the addition of arbutin to brownish guinea pig and human skin tissues. These results suggest that arbutin may be a useful agent for skin whitening. KCI Citation Count: 112 |
| Author | Ha, Sang Keun Kim, Sun Yeou Lim, Yu-Ji Park, Ji-Ho Kim, Seong Min Yoon, Tae-Jin Kang, Chulhun Lee, Eunjoo H. Oh, Myung Sook Kang, Tong Ho |
| Author_xml | – sequence: 1 givenname: Yu-Ji surname: Lim fullname: Lim, Yu-Ji organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University – sequence: 2 givenname: Eunjoo H. surname: Lee fullname: Lee, Eunjoo H. organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University – sequence: 3 givenname: Tong Ho surname: Kang fullname: Kang, Tong Ho organization: Department of Oriental Medicinal Materials and Processing, College of Life Sciences, Kyung Hee University – sequence: 4 givenname: Sang Keun surname: Ha fullname: Ha, Sang Keun organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University – sequence: 5 givenname: Myung Sook surname: Oh fullname: Oh, Myung Sook organization: Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University – sequence: 6 givenname: Seong Min surname: Kim fullname: Kim, Seong Min organization: Department of Dermatology, School of Medicine, Gyeongsang National University – sequence: 7 givenname: Tae-Jin surname: Yoon fullname: Yoon, Tae-Jin organization: Department of Dermatology, School of Medicine, Gyeongsang National University – sequence: 8 givenname: Chulhun surname: Kang fullname: Kang, Chulhun organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University – sequence: 9 givenname: Ji-Ho surname: Park fullname: Park, Ji-Ho email: jihopark@khu.ac.kr organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University – sequence: 10 givenname: Sun Yeou surname: Kim fullname: Kim, Sun Yeou email: sunnykim@khu.ac.kr organization: Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Skin Biotechnology Research Center, Kyung Hee University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19387580$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001336130$$DAccess content in National Research Foundation of Korea (NRF) |
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| Keywords | TRP-1 TRP-2 Skin tissue culture Melanocyte Melanogenesis α-MSH Arbutin Hyperpigmentation Melanin Tyrosinase |
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| SubjectTerms | Agaricales - enzymology alpha-MSH - metabolism Animals Arbutin - pharmacology Cell Line, Tumor Cell Survival - drug effects Cosmetics - pharmacology Dermatologic Agents - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Guinea Pigs Humans Hyperpigmentation - drug therapy Hyperpigmentation - metabolism Hyperpigmentation - physiopathology Medicine Melanins - biosynthesis Melanoma, Experimental - enzymology Melanoma, Experimental - metabolism Middle Aged Monophenol Monooxygenase - metabolism Organ Culture Techniques Pharmacology/Toxicology Pharmacy Skin - drug effects Skin - enzymology Skin - metabolism Skin Pigmentation - drug effects 약학 |
| Title | Inhibitory effects of arbutin on melanin biosynthesis of α-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish guinea pig skin tissues |
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