Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE3-Leiden.CETP mice - Berbée, Jimmy F.P; Wong, Man C; Wang, Yanan; van der Hoorn, José W.A; Khedoe, Padmini P.S.J; van Klinken, Jan B; Mol, Isabel M; Hiemstra, Pieter S; Tsikas, Dimitrios; Romijn, Johannes A; Havekes, Louis M; Princen, Hans M.G; et al. (The Journal of nutritional biochemistry, 2013)
Keywords: administration & dosage; Animals; antioxidant activity; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - pathology; Atorvastatin Calcium; Biomarkers; Biomarkers - blood; blood; blood lipids; cholesterol; Cholesterol, Dietary; Cholesterol, Dietary - administration & dosage; Cholesterol, LDL; Cholesterol, LDL - blood; collagen; diet; drug effects; Drug Synergism; drug therapy; drugs; Female; Heptanoic Acids; Heptanoic Acids - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Inflammation; Inflammation - drug therapy; Lipids; low density lipoprotein; medicinal plants; Mice; Mice, Transgenic; Oxidative stress; Oxidative Stress - drug effects; pathology; pharmacology; phenotype; Pyrroles; Pyrroles - pharmacology; red wines; Resveratrol; Statin; Stilbenes; Stilbenes - pharmacology; therapeutics; CETP; Oxidative stress; MCP-1; IL; WTD; SMC; sE-selectin; Lipids; CXCL1; Inflammation; Statin; LPS; TG; mnsod; HMG-CoA reductase; pon1; RT-PCR; Atherosclerosis; Resveratrol; oxLDL; Ig; 8-iso-PGF2α; E3L; lox-1; chemokine (C-X-C motif) ligand-1; soluble E-selectin; monocyte chemoattractant protein-1; 8-iso-PGF(2α); manganese superoxide dismutase; oxidized LDL; 3-hydroxy-3-methylglutaryl coenzyme A reductase; interleukin; smooth muscle cell; cholesteryl ester transfer protein cox1/-2, cyclooxygenase-1/-2; immunoglobulin; real-time polymerase chain reaction; triglycerides; isoprostane 15(S)-8-iso-prostaglandin F(2α); paraoxonase-1; Western-type diet; lectin-like oxidized low-density lipoprotein receptor-1; APOE3-Leiden transgenic; lipopolysaccharide