Dynamics of Cerebral Function in Patients with Acute Cerebellar Infarction

• Published in: Cerebellum (London, England) Vol. 23; no. 2; pp. 374 - 382
• Main Authors: Wu, Xin, Lei, Ziye, Wu, Yusi, Jiang, Mingqing, Luo, Hua, Chen, Xiu, Ruan, Jianghai
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2024; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Brain; Brain Mapping; Cerebellum; Dizziness - etiology; EEG; Electroencephalography; Humans; Infarction; Localization; Neurobiology; Neurology; Neurosciences; Vertigo; Dizziness; Microstate analysis; Cerebellar infarction; EEG; Vertigo
• ISSN: 1473-4230; 1473-4222; 1473-4230
• DOI: 10.1007/s12311-023-01534-4

   Few studies were devoted to investigating cerebral functional changes after acute cerebellar infarction (CI). The purpose of this study was to examine the brain functional dynamics of CI using electroencephalographic (EEG) microstate analysis. And the possible heterogenicity in neural dynamics between CI with vertigo and CI with dizziness was explored. Thirty-four CI patients and 37 age- and gender-matched healthy controls(HC) were included in the study. Each included subject underwent a 19-channel video EEG examination. Five 10-s resting-state EEG epochs were extracted after data preprocessing. Then, microstate analysis and source localization were performed using the LORETA-KEY tool. Microstate parameters such as duration, coverage, occurrence, and transition probability are all extracted. The current study showed that the duration, coverage, and occurrence of microstate(Ms) B significantly increased in CI patients, but the duration and coverage of MsA and MsD decreased. Compared CI with vertigo to dizziness, finding a decreased trend in the coverage of MsD and the transition from MsA and MsB to MsD. Taken together, our study sheds new light on the dynamics of cerebral function after CI, mainly reflecting increased activity in functional networks involved in MsB and decreased activity in functional networks involved in MsA and MsD. Vertigo and dizziness post-CI may be suggested by cerebral functional dynamics. Further longitudinal studies are needed to validate and explore the alterations in brain dynamics to what extent depict the clinical traits and their potential applications in the recovery of CI.