Is fundoplication necessary after paraesophageal hernia repair? A meta-analysis and systematic review

• Published in: Surgical endoscopy Vol. 36; no. 8; pp. 6300 - 6311
• Main Authors: Clapp, Benjamin, Hamdan, Marah, Mandania, Roshni, Kim, Jisoo, Gamez, Jesus, Hornock, Sasha, Vivar, Andres, Dodoo, Christopher, Davis, Brian
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2022; Springer Nature B.V
• Subjects: 2021 SAGES Poster; Abdominal Surgery; Asymptomatic; Deglutition Disorders - surgery; Dysphagia; Endoscopy; Gastroenterology; Gastroesophageal reflux; Gastroesophageal Reflux - etiology; Gastroesophageal Reflux - surgery; Gynecology; Hepatology; Hernia, Hiatal - complications; Hernias; Herniorrhaphy - adverse effects; Humans; Laparoscopy; Laparoscopy - adverse effects; Length of stay; Literature reviews; Medicine; Medicine & Public Health; Meta-analysis; Mortality; Proctology; Surgery; Systematic review; Treatment Outcome; Fundoplication; Hiatal hernia repair; Paraesophageal hernia; Meta-analysis
• ISSN: 0930-2794; 1432-2218; 1432-2218
• DOI: 10.1007/s00464-022-09024-0

Introduction Paraesophageal hernias are often asymptomatic, but when symptomatic they should be fixed laparoscopically. A cruroplasty of the diaphragmatic pillars is performed and a fundoplication is usually performed at the time. However, there are times, especially in emergency cases, where it is not always possible to perform a fundoplication. We hypothesized there would be no difference in outcomes whether or not a fundoplication is performed as part of a paraesophageal hernia repair. Methods A literature review of available clinical databases was performed using PubMed, Clinical Key and Google Scholar. Our search terms were: “paraesophageal hernia” “paraesophageal hernia repair” “fundoplication” “emergency surgery” “no fundoplication” We excluded studies that were in languages other than English, abstracts and small case series. Results Our search criteria yielded a total of 22 studies published between 1997 and 2020. There were a total of 8600 subjects enrolled into this study. The overall pooled prevalence of fundoplication were estimated as 69% (95% CI: 59%–78%). In patients who underwent fundoplication, the risk of gastroesophageal reflux disease (GERD) was reduced as compared to patients who did not undergo fundoplication (RR: 0.64, 95% CI: 0.40–1.04, p  = 0.069, I 2  = 47.2%). A similar trend was also observed in recurrence (RR: 0.53, 95% CI: 0.27–1.03, p  = 0.061, I 2  = 0.0%) and reoperations (RR: 0.25, 95% CI: 0.02–2.69, p  = 0.25, I 2  = 56.7%). However, patients who underwent fundoplication had an increased risk of dysphagia (RR: 1.68, 95% CI: 0.59–4.81, p  = 0.83, I 2  = 42%). Conclusions There is a higher rate of recurrence of gastroesophageal reflux disease, recurrence of hernia and reoperation when no fundoplication is performed during a paraesophageal hernia repair but a lower risk of dysphagia, but none of these reached statistical significance.(Comment 1) Paraesophageal hernia repair with fundoplication should be performed, but it is acceptable to not do it in certain situations.