The association between urinary organophosphate insecticide metabolites and erectile dysfunction in the United States
Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate...
Saved in:
| Published in | International journal of impotence research Vol. 36; no. 3; pp. 226 - 231 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.05.2024
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0955-9930 1476-5489 1476-5489 |
| DOI | 10.1038/s41443-022-00655-4 |
Cover
| Abstract | Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate the correlation between 4 urinary organophosphate insecticide metabolites and the presence of ED in a representative sample of men aged 20 and older. The dataset including a total of 555 subjects was obtained from the National Health and Nutrition Examination Survey (NHANES) 2003–2004. ED was assessed by a question from a self-report questionnaire. Weighted proportions and multivariable logistic regression analysis were utilized to examine the relationship between organophosphate insecticide metabolite exposure and ED. In multivariable logistic regression analysis, diethylphosphate (DEP) was positively correlated with ED (OR 1.07; 95% CI 1.01–1.14;
P
= 0.033) after full adjustment. Men in DEP tertile 4 had a significant 33% higher risk of ED than those in tertile 1. Furthermore, in a subgroup analysis, our results showed that higher DEP levels were significantly associated with ED in the young age group (20 ≤ age ≤ 39). Our study revealed a significant association between organophosphate insecticide metabolite exposure and an increased risk of ED. Moreover, the correlations were more evident in the young age group. The evaluation of urinary organophosphate insecticide metabolite exposure should be included in the risk assessment of ED. Further study to investigate the underlying mechanism, such as how long the urinary metabolite is present, whether ED is reversible in this population by lowering DEP concentrations, and how exposure to this metabolite affects erectile tissue, is warranted. |
|---|---|
| AbstractList | Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate the correlation between 4 urinary organophosphate insecticide metabolites and the presence of ED in a representative sample of men aged 20 and older. The dataset including a total of 555 subjects was obtained from the National Health and Nutrition Examination Survey (NHANES) 2003–2004. ED was assessed by a question from a self-report questionnaire. Weighted proportions and multivariable logistic regression analysis were utilized to examine the relationship between organophosphate insecticide metabolite exposure and ED. In multivariable logistic regression analysis, diethylphosphate (DEP) was positively correlated with ED (OR 1.07; 95% CI 1.01–1.14; P = 0.033) after full adjustment. Men in DEP tertile 4 had a significant 33% higher risk of ED than those in tertile 1. Furthermore, in a subgroup analysis, our results showed that higher DEP levels were significantly associated with ED in the young age group (20 ≤ age ≤ 39). Our study revealed a significant association between organophosphate insecticide metabolite exposure and an increased risk of ED. Moreover, the correlations were more evident in the young age group. The evaluation of urinary organophosphate insecticide metabolite exposure should be included in the risk assessment of ED. Further study to investigate the underlying mechanism, such as how long the urinary metabolite is present, whether ED is reversible in this population by lowering DEP concentrations, and how exposure to this metabolite affects erectile tissue, is warranted. Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate the correlation between 4 urinary organophosphate insecticide metabolites and the presence of ED in a representative sample of men aged 20 and older. The dataset including a total of 555 subjects was obtained from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. ED was assessed by a question from a self-report questionnaire. Weighted proportions and multivariable logistic regression analysis were utilized to examine the relationship between organophosphate insecticide metabolite exposure and ED. In multivariable logistic regression analysis, diethylphosphate (DEP) was positively correlated with ED (OR 1.07; 95% CI 1.01-1.14; P = 0.033) after full adjustment. Men in DEP tertile 4 had a significant 33% higher risk of ED than those in tertile 1. Furthermore, in a subgroup analysis, our results showed that higher DEP levels were significantly associated with ED in the young age group (20 ≤ age ≤ 39). Our study revealed a significant association between organophosphate insecticide metabolite exposure and an increased risk of ED. Moreover, the correlations were more evident in the young age group. The evaluation of urinary organophosphate insecticide metabolite exposure should be included in the risk assessment of ED. Further study to investigate the underlying mechanism, such as how long the urinary metabolite is present, whether ED is reversible in this population by lowering DEP concentrations, and how exposure to this metabolite affects erectile tissue, is warranted.Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate the correlation between 4 urinary organophosphate insecticide metabolites and the presence of ED in a representative sample of men aged 20 and older. The dataset including a total of 555 subjects was obtained from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. ED was assessed by a question from a self-report questionnaire. Weighted proportions and multivariable logistic regression analysis were utilized to examine the relationship between organophosphate insecticide metabolite exposure and ED. In multivariable logistic regression analysis, diethylphosphate (DEP) was positively correlated with ED (OR 1.07; 95% CI 1.01-1.14; P = 0.033) after full adjustment. Men in DEP tertile 4 had a significant 33% higher risk of ED than those in tertile 1. Furthermore, in a subgroup analysis, our results showed that higher DEP levels were significantly associated with ED in the young age group (20 ≤ age ≤ 39). Our study revealed a significant association between organophosphate insecticide metabolite exposure and an increased risk of ED. Moreover, the correlations were more evident in the young age group. The evaluation of urinary organophosphate insecticide metabolite exposure should be included in the risk assessment of ED. Further study to investigate the underlying mechanism, such as how long the urinary metabolite is present, whether ED is reversible in this population by lowering DEP concentrations, and how exposure to this metabolite affects erectile tissue, is warranted. Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there is no literature regarding the impacts of organophosphate insecticide metabolite exposure on erectile dysfunction (ED). We aimed to evaluate the correlation between 4 urinary organophosphate insecticide metabolites and the presence of ED in a representative sample of men aged 20 and older. The dataset including a total of 555 subjects was obtained from the National Health and Nutrition Examination Survey (NHANES) 2003–2004. ED was assessed by a question from a self-report questionnaire. Weighted proportions and multivariable logistic regression analysis were utilized to examine the relationship between organophosphate insecticide metabolite exposure and ED. In multivariable logistic regression analysis, diethylphosphate (DEP) was positively correlated with ED (OR 1.07; 95% CI 1.01–1.14; P = 0.033) after full adjustment. Men in DEP tertile 4 had a significant 33% higher risk of ED than those in tertile 1. Furthermore, in a subgroup analysis, our results showed that higher DEP levels were significantly associated with ED in the young age group (20 ≤ age ≤ 39). Our study revealed a significant association between organophosphate insecticide metabolite exposure and an increased risk of ED. Moreover, the correlations were more evident in the young age group. The evaluation of urinary organophosphate insecticide metabolite exposure should be included in the risk assessment of ED. Further study to investigate the underlying mechanism, such as how long the urinary metabolite is present, whether ED is reversible in this population by lowering DEP concentrations, and how exposure to this metabolite affects erectile tissue, is warranted. |
| Author | Yang, Zerui Wang, Wei Lin, Lede Gao, Xiaoshuai Zhou, Liang Xiao, Kaiwen Peng, Liao |
| Author_xml | – sequence: 1 givenname: Zerui surname: Yang fullname: Yang, Zerui organization: West China School of Medicine, Sichuan University – sequence: 2 givenname: Wei surname: Wang fullname: Wang, Wei organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University – sequence: 3 givenname: Lede surname: Lin fullname: Lin, Lede organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University – sequence: 4 givenname: Kaiwen surname: Xiao fullname: Xiao, Kaiwen organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University – sequence: 5 givenname: Liao surname: Peng fullname: Peng, Liao organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University – sequence: 6 givenname: Xiaoshuai surname: Gao fullname: Gao, Xiaoshuai organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University – sequence: 7 givenname: Liang orcidid: 0000-0003-3439-0222 surname: Zhou fullname: Zhou, Liang email: zhouliang5678@foxmail.com organization: Department of Urology, Institute of Urology, West China Hospital, Sichuan University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36513813$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtrHDEQhEVwiNdO_kAOQZBLLpO0XjOjYzB5gSGH2GchaXq8MrPSRtIQ_O8t79oEfPBJ0Pqquqk6IycxRSTkPYPPDMT4pUgmpeiA8w6gV6qTr8iGyaHvlBz1CdmAbkOtBZySs1JuAUAD69-QU9ErJkYmNmS92iK1pSQfbA0pUof1H2Kkaw7R5jua8o2Nab9NZb-1FWmIBX0NPkxId1itS0uoWKiNE8X88LUgne7KvEZ_MAyR1rbjOjZson9qMylvyevZLgXfPb7n5Pr7t6uLn93l7x-_Lr5edl4Mqna6H93Axx4kKhQzjo6PIAbRT45p14uBKQ9aaq-En62CUbvZey25xxm0Y-KcfDr67nP6u2KpZheKx2WxEdNaDB-UVMA1iIZ-fIbepjXHdp0RIIXiDBhv1IdHanU7nMw-h11LyTwF2oDxCPicSsk4Gx_qIdmabVgMA_PQnTl2Z1p35tCdkU3Kn0mf3F8UiaOoNDjeYP5_9guqe17rrJA |
| CitedBy_id | crossref_primary_10_1007_s40618_023_02155_8 crossref_primary_10_1080_01635581_2023_2272800 |
| Cites_doi | 10.1038/sj.jea.7500322 10.1093/ije/dyp269 10.1111/j.1525-1497.2005.0076.x 10.1016/j.tox.2012.11.001 10.1111/j.1743-6109.2006.00331.x 10.1016/j.envint.2019.105383 10.1111/j.1743-6109.2010.01780.x 10.1016/j.reprotox.2015.04.005 10.1016/j.forsciint.2011.10.019 10.1016/j.tox.2022.153317 10.1016/j.amjmed.2006.06.010 10.3390/ijerph8083063 10.1021/es802593t 10.1111/jsm.12848 10.1111/jsm.12977 10.1016/j.envpol.2014.09.012 10.1016/S0022-5347(17)34871-1 10.2174/1570159X1406160627150804 10.1046/j.1464-410x.1999.00142.x 10.1016/0006-8993(94)90225-9 10.1016/j.toxrep.2019.11.005 10.1111/j.1743-6109.2008.00971.x 10.1016/j.neuroscience.2010.01.025 10.1016/j.envint.2020.105461 10.1016/j.tox.2009.11.022 10.1016/j.envres.2014.02.009 10.1016/j.tox.2007.05.007 10.1111/jsm.12854 10.1046/j.1442-2042.2001.00258.x 10.1039/b505587c 10.1016/j.juro.2007.01.057 10.1016/j.clinbiochem.2015.10.004 10.3390/molecules24102003 10.1515/bchm1.1886.10.5.391 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature Limited 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA AN0 BENPR CCPQU FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.1038/s41443-022-00655-4 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central ProQuest One Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Academic Middle East (New) MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1476-5489 |
| EndPage | 231 |
| ExternalDocumentID | 36513813 10_1038_s41443_022_00655_4 |
| Genre | Journal Article |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GroupedDBID | --- -Q- 0R~ 29J 2WC 36B 39C 3V. 4.4 406 53G 5GY 5RE 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABAWZ ABDBF ABJNI ABUWG ABZZP ACAOD ACGFS ACKTT ACRQY ACUHS ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AN0 AXYYD B0M BAWUL BENPR BKKNO BNQBC BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DPUIP DU5 E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL ESX F5P FDQFY FERAY FIGPU FIZPM FSGXE FYUFA HMCUK HZ~ IAO IHR IHW INH INR ITC IWAJR JSO JZLTJ KQ8 M1P N8Y NAO NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP ~8M AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7XB 8FK ABRTQ K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 PUEGO |
| ID | FETCH-LOGICAL-c375t-968b728604e5e3fe8b2803736db19b63715c0949c53cfa5089bfcc942cef09b13 |
| IEDL.DBID | 7X7 |
| ISSN | 0955-9930 1476-5489 |
| IngestDate | Fri Sep 05 10:23:47 EDT 2025 Sat Aug 23 14:57:21 EDT 2025 Sat May 10 01:40:49 EDT 2025 Tue Jul 01 02:10:54 EDT 2025 Thu Apr 24 22:58:56 EDT 2025 Fri Feb 21 02:38:22 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | 2022. The Author(s), under exclusive licence to Springer Nature Limited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c375t-968b728604e5e3fe8b2803736db19b63715c0949c53cfa5089bfcc942cef09b13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-3439-0222 |
| PMID | 36513813 |
| PQID | 3043521012 |
| PQPubID | 46833 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_2754502903 proquest_journals_3043521012 pubmed_primary_36513813 crossref_citationtrail_10_1038_s41443_022_00655_4 crossref_primary_10_1038_s41443_022_00655_4 springer_journals_10_1038_s41443_022_00655_4 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-05-01 |
| PublicationDateYYYYMMDD | 2024-05-01 |
| PublicationDate_xml | – month: 05 year: 2024 text: 2024-05-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York |
| PublicationSubtitle | Your Sexual Medicine Journal |
| PublicationTitle | International journal of impotence research |
| PublicationTitleAbbrev | Int J Impot Res |
| PublicationTitleAlternate | Int J Impot Res |
| PublicationYear | 2024 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Kavvalakis, Tsatsakis (CR25) 2012; 218 Luo, Liu, Wang, Aimuzi, Luo, Ao (CR13) 2020; 136 Latini, Penson, Wallace, Lubeck, Lue (CR4) 2006; 3 Imam, Ogunniyi, Ibrahim, Abdulmajeed, Aboyeji, Lawan (CR33) 2018; 33 Roca, Miralles-Marco, Ferré, Pérez, Yusà (CR24) 2014; 131 Cole, Chu, Nie, Schisterman (CR19) 2009; 38 Busby-Hjerpe, Campbell, Smith, Lee, Poet, Barr (CR23) 2010; 268 CR17 Buvat, Maggi, Gooren, Guay, Kaufman, Morgentaler (CR28) 2010; 7 O’Donnell, Araujo, Goldstein, McKinlay (CR37) 2005; 20 Pastuszak, Hyman, Yadav, Godoy, Lipshultz, Araujo (CR5) 2015; 12 Feldman, Goldstein, Hatzichristou, Krane, McKinlay (CR1) 1994; 151 Belba, Cortelazzo, Andrea, Durante, Nigi, Dotta (CR35) 2016; 49 Sette, Alugubelly, Glenn, Guo-Ross, Parkes, Wilson (CR29) 2022; 480 Karumuri, Singh, Naqvi, Mishra, Flora (CR34) 2019; 6 Maeda, Matsuoka, Yamaguchi (CR31) 1994; 652 Chew, Bremner, Stuckey, Earle, Jamrozik (CR36) 2009; 6 Yang, Zhao, Ren, Pang, Li (CR27) 2020; 135 Rush, Liu, Hjelmhaug, Lobner (CR30) 2010; 166 CR8 Bravo, Caltabiano, Weerasekera, Whitehead, Fernandez, Needham (CR18) 2004; 14 Makinen, Makinen, Koistinen, Pasanen, Pasanen, Kalliokoski (CR11) 2009; 43 Loprinzi, Edwards (CR20) 2015; 12 Wei, Li, Zhuo, Liao, Xie, Guo (CR9) 2015; 196 Omoike, Lewis, Meeker (CR14) 2015; 53 CR26 Marumo, Nakashima, Murai (CR21) 2001; 8 Kumar (CR32) 2016; 14 Barr, Wong, Bravo, Weerasekera, Odetokun, Restrepo (CR7) 2011; 8 Marklund, Andersson, Haglund (CR10) 2005; 7 Wang, Liu, Yin (CR12) 2010; 22 Wessells, Joyce, Wise, Wilt (CR3) 2007; 177 Timchalk, Busby, Campbell, Needham, Barr (CR22) 2007; 237 Luo, Zhang, Liao, Tang, Huang, Xie (CR15) 2015; 12 Ayta, McKinlay, Krane (CR2) 1999; 84 Selvin, Burnett, Platz (CR16) 2007; 120 Aguilar-Garduño, Lacasaña, Blanco-Muñoz, Rodríguez-Barranco, Hernández, Bassol (CR6) 2013; 307 DM Latini (655_CR4) 2006; 3 SR Cole (655_CR19) 2009; 38 FW Yang (655_CR27) 2020; 135 AL Busby-Hjerpe (655_CR23) 2010; 268 K Luo (655_CR13) 2020; 136 M Roca (655_CR24) 2014; 131 655_CR26 H Wessells (655_CR3) 2007; 177 C Aguilar-Garduño (655_CR6) 2013; 307 A Imam (655_CR33) 2018; 33 AW Pastuszak (655_CR5) 2015; 12 HA Feldman (655_CR1) 1994; 151 MSE Makinen (655_CR11) 2009; 43 MP Kavvalakis (655_CR25) 2012; 218 R Bravo (655_CR18) 2004; 14 K Marumo (655_CR21) 2001; 8 AB O’Donnell (655_CR37) 2005; 20 KN Sette (655_CR29) 2022; 480 655_CR8 A Belba (655_CR35) 2016; 49 SB Karumuri (655_CR34) 2019; 6 A Kumar (655_CR32) 2016; 14 E Selvin (655_CR16) 2007; 120 T Rush (655_CR30) 2010; 166 KK Chew (655_CR36) 2009; 6 IA Ayta (655_CR2) 1999; 84 PD Loprinzi (655_CR20) 2015; 12 Y Luo (655_CR15) 2015; 12 655_CR17 C Timchalk (655_CR22) 2007; 237 GL Wei (655_CR9) 2015; 196 N Maeda (655_CR31) 1994; 652 DB Barr (655_CR7) 2011; 8 A Marklund (655_CR10) 2005; 7 OE Omoike (655_CR14) 2015; 53 X Wang (655_CR12) 2010; 22 J Buvat (655_CR28) 2010; 7 |
| References_xml | – volume: 14 start-page: 249 year: 2004 end-page: 59 ident: CR18 article-title: Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification publication-title: J Expos Anal Environ Epidemiol doi: 10.1038/sj.jea.7500322 – volume: 38 start-page: 1674 year: 2009 end-page: 80 ident: CR19 article-title: Estimating the odds ratio when exposure has a limit of detection publication-title: Int J Epidemiol doi: 10.1093/ije/dyp269 – volume: 20 start-page: 515 year: 2005 end-page: 9 ident: CR37 article-title: The validity of a single-question self-report of erectile dysfunction. Results from the Massachusetts Male Aging Study publication-title: J Gen Intern Med doi: 10.1111/j.1525-1497.2005.0076.x – volume: 307 start-page: 55 year: 2013 end-page: 65 ident: CR6 article-title: Changes in male hormone profile after occupational organophosphate exposure. A longitudinal study publication-title: Toxicology doi: 10.1016/j.tox.2012.11.001 – volume: 3 start-page: 1059 year: 2006 end-page: 67 ident: CR4 article-title: Clinical and psychosocial characteristics of men with erectile dysfunction: baseline data from ExCEED publication-title: J Sex Med doi: 10.1111/j.1743-6109.2006.00331.x – volume: 135 start-page: 105383 year: 2020 ident: CR27 article-title: Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches publication-title: Environ Int doi: 10.1016/j.envint.2019.105383 – volume: 7 start-page: 1627 year: 2010 end-page: 56 ident: CR28 article-title: Endocrine aspects of male sexual dysfunctions publication-title: J Sex Med doi: 10.1111/j.1743-6109.2010.01780.x – volume: 53 start-page: 99 year: 2015 end-page: 104 ident: CR14 article-title: Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999-2002 publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2015.04.005 – volume: 218 start-page: 111 year: 2012 end-page: 22 ident: CR25 article-title: The atlas of dialkylphosphates; assessment of cumulative human organophosphorus pesticides’ exposure publication-title: Forensic Sci Int doi: 10.1016/j.forsciint.2011.10.019 – volume: 480 start-page: 153317 year: 2022 ident: CR29 article-title: The mechanistic basis for the toxicity difference between juvenile rats and mice following exposure to the agricultural insecticide chlorpyrifos publication-title: Toxicology doi: 10.1016/j.tox.2022.153317 – volume: 120 start-page: 151 year: 2007 end-page: 7 ident: CR16 article-title: Prevalence and risk factors for erectile dysfunction in the US publication-title: Am J Med doi: 10.1016/j.amjmed.2006.06.010 – volume: 8 start-page: 3063 year: 2011 end-page: 98 ident: CR7 article-title: Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004 publication-title: Int J Environ Res public health doi: 10.3390/ijerph8083063 – volume: 43 start-page: 941 year: 2009 end-page: 7 ident: CR11 article-title: Respiratory and dermal exposure to organophosphorus flame retardants and tetrabromobisphenol A at five work environments publication-title: Environ Sci Technol doi: 10.1021/es802593t – volume: 12 start-page: 975 year: 2015 end-page: 84 ident: CR5 article-title: Erectile dysfunction as a marker for cardiovascular disease diagnosis and intervention: a cost analysis publication-title: J Sex Med doi: 10.1111/jsm.12848 – ident: CR8 – volume: 12 start-page: 1862 year: 2015 end-page: 4 ident: CR20 article-title: Association between objectively measured physical activity and erectile dysfunction among a nationally representative sample of American Men publication-title: J Sex Med doi: 10.1111/jsm.12977 – volume: 196 start-page: 29 year: 2015 end-page: 46 ident: CR9 article-title: Organophosphorus flame retardants and plasticizers: sources, occurrence, toxicity and human exposure publication-title: Environ Pollut (Barking, Essex: 1987) doi: 10.1016/j.envpol.2014.09.012 – volume: 151 start-page: 54 year: 1994 end-page: 61 ident: CR1 article-title: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study publication-title: J Urol doi: 10.1016/S0022-5347(17)34871-1 – volume: 14 start-page: 565 year: 2016 end-page: 6 ident: CR32 article-title: Editorial (Thematic selection: mitochondrial dysfunction & neurological disorders) publication-title: Curr Neuropharmacol doi: 10.2174/1570159X1406160627150804 – volume: 84 start-page: 50 year: 1999 end-page: 56 ident: CR2 article-title: The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences publication-title: BJU Int doi: 10.1046/j.1464-410x.1999.00142.x – volume: 652 start-page: 181 year: 1994 end-page: 9 ident: CR31 article-title: Possible involvement of the septo-hippocampal cholinergic and raphe-hippocampal serotonergic activations in the penile erection induced by fenfluramine in rats publication-title: Brain Res doi: 10.1016/0006-8993(94)90225-9 – ident: CR17 – volume: 6 start-page: 1295 year: 2019 end-page: 303 ident: CR34 article-title: Impact of chronic low dose exposure of monocrotophos in rat brain: Oxidative/ nitrosative stress, neuronal changes and cholinesterase activity publication-title: Toxicol Rep doi: 10.1016/j.toxrep.2019.11.005 – volume: 6 start-page: 222 year: 2009 end-page: 31 ident: CR36 article-title: Is the relationship between cigarette smoking and male erectile dysfunction independent of cardiovascular disease? Findings from a population-based cross-sectional study publication-title: J Sex Med doi: 10.1111/j.1743-6109.2008.00971.x – volume: 166 start-page: 899 year: 2010 end-page: 906 ident: CR30 article-title: Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.01.025 – volume: 136 start-page: 105461 year: 2020 ident: CR13 article-title: Associations between organophosphate esters and sex hormones among 6–19-year old children and adolescents in NHANES 2013–2014 publication-title: Environ Int doi: 10.1016/j.envint.2020.105461 – volume: 268 start-page: 55 year: 2010 end-page: 63 ident: CR23 article-title: Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat publication-title: Toxicology doi: 10.1016/j.tox.2009.11.022 – volume: 131 start-page: 77 year: 2014 end-page: 85 ident: CR24 article-title: Biomonitoring exposure assessment to contemporary pesticides in a school children population of Spain publication-title: Environ Res doi: 10.1016/j.envres.2014.02.009 – volume: 237 start-page: 145 year: 2007 end-page: 57 ident: CR22 article-title: Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat publication-title: Toxicology doi: 10.1016/j.tox.2007.05.007 – volume: 12 start-page: 1165 year: 2015 end-page: 74 ident: CR15 article-title: Sex hormones predict the incidence of erectile dysfunction: From a Population-Based Prospective Cohort Study (FAMHES) publication-title: J Sex Med doi: 10.1111/jsm.12854 – volume: 8 start-page: 53 year: 2001 end-page: 59 ident: CR21 article-title: Age-related prevalence of erectile dysfunction in Japan: assessment by the International Index of Erectile Function publication-title: Int J Urol: Off J Jpn Urol Assoc doi: 10.1046/j.1442-2042.2001.00258.x – ident: CR26 – volume: 22 start-page: 1983 year: 2010 end-page: 92 ident: CR12 article-title: The pollution status and research progress on organophosphate ester flame retardants publication-title: Prog Chem – volume: 7 start-page: 814 year: 2005 end-page: 9 ident: CR10 article-title: Organophosphorus flame retardants and plasticizers in air from various indoor environments publication-title: J Environ Monit doi: 10.1039/b505587c – volume: 33 start-page: 83 year: 2018 end-page: 88 ident: CR33 article-title: Dichlorvos induced oxidative and neuronal responses in rats: mitigative efficacy of Nigella sativa (Black Cumin) publication-title: Niger J Physiol Sci: Off Publ Physiol Soc Niger – volume: 177 start-page: 1675 year: 2007 end-page: 81 ident: CR3 article-title: Erectile dysfunction publication-title: J Urol doi: 10.1016/j.juro.2007.01.057 – volume: 49 start-page: 70 year: 2016 end-page: 78 ident: CR35 article-title: Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2015.10.004 – volume: 12 start-page: 1165 year: 2015 ident: 655_CR15 publication-title: J Sex Med doi: 10.1111/jsm.12854 – volume: 7 start-page: 814 year: 2005 ident: 655_CR10 publication-title: J Environ Monit doi: 10.1039/b505587c – volume: 49 start-page: 70 year: 2016 ident: 655_CR35 publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2015.10.004 – ident: 655_CR26 doi: 10.3390/molecules24102003 – volume: 14 start-page: 249 year: 2004 ident: 655_CR18 publication-title: J Expos Anal Environ Epidemiol doi: 10.1038/sj.jea.7500322 – volume: 135 start-page: 105383 year: 2020 ident: 655_CR27 publication-title: Environ Int doi: 10.1016/j.envint.2019.105383 – volume: 14 start-page: 565 year: 2016 ident: 655_CR32 publication-title: Curr Neuropharmacol doi: 10.2174/1570159X1406160627150804 – volume: 307 start-page: 55 year: 2013 ident: 655_CR6 publication-title: Toxicology doi: 10.1016/j.tox.2012.11.001 – volume: 237 start-page: 145 year: 2007 ident: 655_CR22 publication-title: Toxicology doi: 10.1016/j.tox.2007.05.007 – volume: 151 start-page: 54 year: 1994 ident: 655_CR1 publication-title: J Urol doi: 10.1016/S0022-5347(17)34871-1 – volume: 22 start-page: 1983 year: 2010 ident: 655_CR12 publication-title: Prog Chem – volume: 218 start-page: 111 year: 2012 ident: 655_CR25 publication-title: Forensic Sci Int doi: 10.1016/j.forsciint.2011.10.019 – volume: 7 start-page: 1627 year: 2010 ident: 655_CR28 publication-title: J Sex Med doi: 10.1111/j.1743-6109.2010.01780.x – volume: 652 start-page: 181 year: 1994 ident: 655_CR31 publication-title: Brain Res doi: 10.1016/0006-8993(94)90225-9 – volume: 6 start-page: 1295 year: 2019 ident: 655_CR34 publication-title: Toxicol Rep doi: 10.1016/j.toxrep.2019.11.005 – volume: 268 start-page: 55 year: 2010 ident: 655_CR23 publication-title: Toxicology doi: 10.1016/j.tox.2009.11.022 – volume: 53 start-page: 99 year: 2015 ident: 655_CR14 publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2015.04.005 – volume: 12 start-page: 975 year: 2015 ident: 655_CR5 publication-title: J Sex Med doi: 10.1111/jsm.12848 – volume: 3 start-page: 1059 year: 2006 ident: 655_CR4 publication-title: J Sex Med doi: 10.1111/j.1743-6109.2006.00331.x – volume: 8 start-page: 3063 year: 2011 ident: 655_CR7 publication-title: Int J Environ Res public health doi: 10.3390/ijerph8083063 – volume: 196 start-page: 29 year: 2015 ident: 655_CR9 publication-title: Environ Pollut (Barking, Essex: 1987) doi: 10.1016/j.envpol.2014.09.012 – volume: 43 start-page: 941 year: 2009 ident: 655_CR11 publication-title: Environ Sci Technol doi: 10.1021/es802593t – volume: 33 start-page: 83 year: 2018 ident: 655_CR33 publication-title: Niger J Physiol Sci: Off Publ Physiol Soc Niger – volume: 6 start-page: 222 year: 2009 ident: 655_CR36 publication-title: J Sex Med doi: 10.1111/j.1743-6109.2008.00971.x – volume: 12 start-page: 1862 year: 2015 ident: 655_CR20 publication-title: J Sex Med doi: 10.1111/jsm.12977 – volume: 177 start-page: 1675 year: 2007 ident: 655_CR3 publication-title: J Urol doi: 10.1016/j.juro.2007.01.057 – volume: 480 start-page: 153317 year: 2022 ident: 655_CR29 publication-title: Toxicology doi: 10.1016/j.tox.2022.153317 – volume: 20 start-page: 515 year: 2005 ident: 655_CR37 publication-title: J Gen Intern Med doi: 10.1111/j.1525-1497.2005.0076.x – volume: 136 start-page: 105461 year: 2020 ident: 655_CR13 publication-title: Environ Int doi: 10.1016/j.envint.2020.105461 – volume: 120 start-page: 151 year: 2007 ident: 655_CR16 publication-title: Am J Med doi: 10.1016/j.amjmed.2006.06.010 – volume: 131 start-page: 77 year: 2014 ident: 655_CR24 publication-title: Environ Res doi: 10.1016/j.envres.2014.02.009 – volume: 166 start-page: 899 year: 2010 ident: 655_CR30 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.01.025 – volume: 84 start-page: 50 year: 1999 ident: 655_CR2 publication-title: BJU Int doi: 10.1046/j.1464-410x.1999.00142.x – ident: 655_CR8 – volume: 38 start-page: 1674 year: 2009 ident: 655_CR19 publication-title: Int J Epidemiol doi: 10.1093/ije/dyp269 – volume: 8 start-page: 53 year: 2001 ident: 655_CR21 publication-title: Int J Urol: Off J Jpn Urol Assoc doi: 10.1046/j.1442-2042.2001.00258.x – ident: 655_CR17 doi: 10.1515/bchm1.1886.10.5.391 |
| SSID | ssj0009016 |
| Score | 2.4228833 |
| Snippet | Organophosphate (OP) insecticides are the main chemicals used in agriculture for pest elimination, and they have been linked with many diseases. However, there... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 226 |
| SubjectTerms | 692/499 692/699/2732/515 Adult Age groups Aged Erectile dysfunction Erectile Dysfunction - chemically induced Erectile Dysfunction - epidemiology Erectile Dysfunction - urine Humans Insecticides Insecticides - adverse effects Insecticides - urine Male Medicine Medicine & Public Health Metabolites Middle Aged Nutrition Surveys Organophosphates - urine Regression analysis Reproductive Medicine rology United States - epidemiology Urology Young Adult |
| Title | The association between urinary organophosphate insecticide metabolites and erectile dysfunction in the United States |
| URI | https://link.springer.com/article/10.1038/s41443-022-00655-4 https://www.ncbi.nlm.nih.gov/pubmed/36513813 https://www.proquest.com/docview/3043521012 https://www.proquest.com/docview/2754502903 |
| Volume | 36 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Na9wwEB3aBEovpd_dNg0q9NaK2Jb8oVNpS0IoJJTSwN6EJI_JQmJv491D_n1nZO0uJTRn27LQk2beaKR5AB9LotB17lAi6kABSuuk0yz3grrLGlRoPO93nJ1Xpxf6x7ycpw23MR2r3NjEaKjbIfAe-RGF3cQVuBrVl-UfyapRnF1NEhoPYT8nJsLSDfW83hXdzaL0KVdZk-SHs3RpJlPN0agpkuAMZiHZC5dS_-uY7rDNO5nS6IBOnsKTxBzF1wnqZ_AA--fw6Czlxl_AmhAXbjfaIh3BEryf7m5uRRRwGpaXw7i8JIYpFv3I1i4sWhTXuKLZwPeRR-H6VmA0hFco2tuRXV9scNELootioqlioqkv4eLk-Pf3U5lEFWRQdbmSpmp8XTRVprFE1WHjWZ-qVlXrc-MrVedloJDPhFKFzhF9M74LwegiYJcZn6tXsNcPPb4BYbTzZDCULrDVGkPjWsMFCjvVKaJhbgb5ZkRtSBXHWfjiysbMt2rshIIlFGxEweoZfNp-s5zqbdz79sEGKJvW3mh3M2UGH7aPadVwKsT1OKxHW9TEHLPCZGoGryeAt79TVZkTj6EnnzeI7xr_f1_e3t-Xd_C4ID40nZU8gL3VzRrfE59Z-cM4aQ9h_9vx-c9ffwFfIvGi |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrQRcEG-2FDASnMBqEjsPHyrEo9WWdlcItVJvruNM1JVKsm12hfbP8dsYJ86uUEVvPSdxLM94_M2MZz6AdzFB6DQ0yBGlJQelMNxIR_eCsgwyFKhyF-8YT5LRifx-Gp9uwJ--FsZdq-xtYmuoi9q6GPkOud2EFVw3qk-zS-5Yo1x2tafQMJ5aodhtW4z5wo5DXP4mF67ZPfhG8n4fRft7x19H3LMMcCvSeM5VkuVplCWBxBhFiVnuCJtSkRR5qPJEpGFsyQdSNha2NIRnVF5aq2RksQxUHgoa9w5sShdAGcDml73Jj5_rtr9BS77q-rxxQgKBL9sJRLbTSPJlXA414g4HxFz-ezRew7vXcrXtEbj_EB547Mo-d8r2CDawegx3xz47_wQWpHPMrOXN_CUw5iL65mrJWgqpenZeN7NzwrhsWjXO3tppgewXzkkfXUV0w0xVMGxN8QWyYtm4w7cdcFoxAqysA8qsA8pP4eRWFvwZDKq6whfAlDQ5mSwhIyykRJuZQrkWiaUoBQFBM4SwX1Ftfc9zR71xodvcu8h0JwVNUtCtFLQcwofVN7Ou48eNb2_3gtJ-9zd6ratDeLt6TPvWJWNMhfWi0VFK2DWIVCCG8LwT8Op3IolDQlL05GMv8fXg_5_L1s1zeQP3RsfjI310MDl8CfcjQmfdzc1tGMyvFviK0NU8f-1VmMHZbe-av5u5Mss |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VVqq4IN5dKMVIcIJok9h5-FChvlYtpasKUak349gTdaWSLM2u0P5FfhXjxNkVquit5ySO5RmPv_E8PoD3CUHoLNIYIApDDorVgRaO7gVFGebIURbuvuNsnB5fiC-XyeUa_OlrYVxaZW8TW0Nta-PuyIfkdhNWcN2ohqVPizg_HH2e_gocg5SLtPZ0GtrTLNjdtt2YL_I4xcVvcuea3ZNDkv2HOB4dfT84DjzjQGB4lswCmeZFFudpKDBBXmJeOPKmjKe2iGSR8ixKDPlD0iTclJqwjSxKY6SIDZahLCJO4z6AjYxOfXIEN_aPxuffVi2Aw5aI1fV8CwgVhL6EJ-T5sBHk17h4ahw4TJAE4t9j8hb2vRW3bY_D0WN45HEs2-sU7wmsYfUUNs98pP4ZzEn_mF7JnvmEMOZu9_XNgrV0UvX0qm6mV4R32aRqnO01E4vsJ85IN111dMN0ZRm2ZvkamV007iBuB5xUjMAr60Az60Dzc7i4lwV_AetVXeEWMCl0QeaLixitEGhybaVrl1jykhMo1AOI-hVVxvc_dzQc16qNw_NcdVJQJAXVSkGJAXxcfjPtun_c-fZ2LyjlLUGjVno7gHfLx7SHXWBGV1jPGxVnhGPDWIZ8AC87AS9_x9MkIlRFTz71El8N_v-5vLp7Lm9hk3aP-noyPn0ND2MCal0S5zasz27m-IaA1qzY8RrM4Md9b5q_PDo3Dw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+association+between+urinary+organophosphate+insecticide+metabolites+and+erectile+dysfunction+in+the+United+States&rft.jtitle=International+journal+of+impotence+research&rft.au=Yang%2C+Zerui&rft.au=Wang%2C+Wei&rft.au=Lin%2C+Lede&rft.au=Xiao%2C+Kaiwen&rft.date=2024-05-01&rft.eissn=1476-5489&rft.volume=36&rft.issue=3&rft.spage=226&rft_id=info:doi/10.1038%2Fs41443-022-00655-4&rft_id=info%3Apmid%2F36513813&rft.externalDocID=36513813 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0955-9930&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0955-9930&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0955-9930&client=summon |