Quantitative synthetic MRI reveals grey matter abnormalities in children with drug-naïve attention-deficit/hyperactivity disorder

• Published in: Brain imaging and behavior Vol. 16; no. 1; pp. 406 - 414
• Main Authors: Su, Shu, Chen, Yingqian, Dai, Yan, Lin, Liping, Qian, Long, Zhou, Qin, Zou, Mengsha, Zhang, Hongyu, Liu, Meina, Xiang, Xianhong, Yang, Zhiyun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2022; Springer Nature B.V
• Subjects: Abnormalities; Attention Deficit Disorder with Hyperactivity - diagnostic imaging; Attention deficit hyperactivity disorder; Biomedical and Life Sciences; Biomedicine; Brain; Brain - diagnostic imaging; Brain Mapping; Cerebellum; Cerebral Cortex; Child; Correlation analysis; Gray Matter - diagnostic imaging; Humans; Hyperactivity; Iron deficiency; Magnetic Resonance Imaging; Medical imaging; Myelin; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; Nutrient deficiency; Original Research; Patients; Pediatrics; Pharmaceutical Preparations; Psychiatry; Substantia grisea; Attention-deficit/hyperactivity disorder; Quantitative MRI; Grey matter
• ISSN: 1931-7557; 1931-7565; 1931-7565
• DOI: 10.1007/s11682-021-00514-8

To investigate the quantitative profiles of brain grey matter (GM) in pediatric drug-naïve ADHD patients using synthetic magnetic resonance imaging (SyMRI). A total of 37 drug-naïve pediatric ADHD and 27 age- and gender-matched healthy controls (HC) were enrolled in this study. Each subject underwent both SyMRI and conventional 3D T1-FSPGR scans. Quantitative parameters, T1 and T2 maps, were extracted from the SyMRI data. Between-group quantitative maps were compared using a general linear model analysis. Pearson correlation analysis was conducted to assess the association between significantly altered MR indices and clinical measurements in ADHD. Compared with the HC group, altered T1 and T2 relaxometry times in the ADHD group were mainly distributed in GM regions of the cerebellum, attention and execution control network, default mode network, and limbic areas. Moreover, the T1 value of the right cerebellum 8 was negatively correlated with the attention concentration level in ADHD (R = 0.140, P  = 0.0225). With regards to T2 map, the associations were observed between the attention level of ADHD patients and left fusiform gyrus (R = 0.251, P  = 0.0016), and right cerebellum crus2 (R = 0.142, P  = 0.0214). Altered T1, T2 values found in specific regions of GM, including cerebellum, attention and execution control network, default mode network, and limbic areas, may reveal widespread micromorphology changes, i.e., brain iron deficiency, low myelin content, and enlarged vascular interstitial space in ADHD patients. Thus, T1, T2 values might be promising imaging markers for future ADHD studies.