TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function - Ba, Wei; Yan, Yan; Reijnders, Margot R.F.; Schuurs-Hoeijmakers, Janneke H.M.; Feenstra, Ilse; Bongers, Ernie M.H.F.; Bosch, Daniëlle G.M.; De Leeuw, Nicole; Pfundt, Rolph; Gilissen, Christian; De Vries, Petra F.; Veltman, Joris A.; et al. (Human molecular genetics, 2016)
Keywords: Adult; Animals; Autistic Disorder - genetics; Autistic Disorder - metabolism; Autistic Disorder - pathology; Child; Female; Gene Expression; Guanine Nucleotide Exchange Factors - deficiency; Guanine Nucleotide Exchange Factors - genetics; Hippocampus - metabolism; Hippocampus - pathology; Humans; Intellectual Disability - genetics; Intellectual Disability - metabolism; Intellectual Disability - pathology; Male; Mutation; Neurogenesis; Neurons - metabolism; Neurons - pathology; Primary Cell Culture; Protein-Serine-Threonine Kinases - deficiency; Protein-Serine-Threonine Kinases - genetics; Psychomotor Agitation - genetics; Psychomotor Agitation - metabolism; Psychomotor Agitation - pathology; Rats; Sequence Analysis, DNA; Severity of Illness Index; Synapses - metabolism; Synapses - pathology