Construction of efficient classes of circular balanced repeated measurements designs with R

Pharmacology, medicine, psychology, and the animal sciences all employ repeated measurement designs (RMDs). However, RMDs may experience carryover effects, which are the primary cause of bias in treatment effect estimation. In order to eliminate the carryover effects for odd v (the number of treatme...

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Published inCommunications in statistics. Theory and methods Vol. 54; no. 1; pp. 34 - 48
Main Authors Riaz, Muhammad, Ul Hassan, Mahmood, Tahir, M. H., Kashif Rasheed, H. M., Khan, Abid, Ahmed, Rashid
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 02.01.2025
Taylor & Francis Ltd
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Online AccessGet full text
ISSN0361-0926
1532-415X
1532-415X
DOI10.1080/03610926.2023.2300307

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Abstract Pharmacology, medicine, psychology, and the animal sciences all employ repeated measurement designs (RMDs). However, RMDs may experience carryover effects, which are the primary cause of bias in treatment effect estimation. In order to eliminate the carryover effects for odd v (the number of treatments), minimal circular balanced and strongly balanced repeated measurement designs (RMDs) are the ones that should be used. The minimal circular partially balanced and weakly balanced RMDs are used for even v. In order to obtain these important classes of minimal circular RMDs in periods of equal, two, and three different sizes, an R-based algorithm is developed in this article. The newly developed algorithm has made so simple the construction of balanced RMDs and their generalized classes. As a result, it is a novel piece of research.
AbstractList Pharmacology, medicine, psychology, and the animal sciences all employ repeated measurement designs (RMDs). However, RMDs may experience carryover effects, which are the primary cause of bias in treatment effect estimation. In order to eliminate the carryover effects for odd v (the number of treatments), minimal circular balanced and strongly balanced repeated measurement designs (RMDs) are the ones that should be used. The minimal circular partially balanced and weakly balanced RMDs are used for even v. In order to obtain these important classes of minimal circular RMDs in periods of equal, two, and three different sizes, an R-based algorithm is developed in this article. The newly developed algorithm has made so simple the construction of balanced RMDs and their generalized classes. As a result, it is a novel piece of research.
Author Riaz, Muhammad
Tahir, M. H.
Ahmed, Rashid
Kashif Rasheed, H. M.
Khan, Abid
Ul Hassan, Mahmood
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Snippet Pharmacology, medicine, psychology, and the animal sciences all employ repeated measurement designs (RMDs). However, RMDs may experience carryover effects,...
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SubjectTerms Algorithms
carryover effects
circular RMDs
Direct effects
Pharmacology
repeated measurements designs
Title Construction of efficient classes of circular balanced repeated measurements designs with R
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