Medium optimization for the production of the aroma compound 2-phenylethanol using a genetic algorithm
Using a genetic algorithm, 13 medium constituents and the temperature were varied to improve the bioconversion of l-phenylalanine (l-phe) to 2-phenylethanol (2-PE) with Kluyveromyces marxianus CBS 600. Within four generations plus an additional temperature screening, corresponding to 98 parallel exp...
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| Published in | Journal of molecular catalysis. B, Enzymatic Vol. 29; no. 1-6; pp. 187 - 193 |
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| Main Authors | , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
21.06.2004
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1381-1177 1873-3158 |
| DOI | 10.1016/j.molcatb.2003.10.014 |
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| Abstract | Using a genetic algorithm, 13 medium constituents and the temperature were varied to improve the bioconversion of l-phenylalanine (l-phe) to 2-phenylethanol (2-PE) with Kluyveromyces marxianus CBS 600. Within four generations plus an additional temperature screening, corresponding to 98 parallel experiments altogether, a maximum 2-PE concentration of 5.6g/l, equivalent to an increase of 87% compared to the non-optimized medium was obtained. The vitamin content of the medium had to be raised significantly. |
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| AbstractList | Using a genetic algorithm, 13 medium constituents and the temperature were varied to improve the bioconversion of l-phenylalanine (l-phe) to 2-phenylethanol (2-PE) with Kluyveromyces marxianus CBS 600. Within four generations plus an additional temperature screening, corresponding to 98 parallel experiments altogether, a maximum 2-PE concentration of 5.6g/l, equivalent to an increase of 87% compared to the non-optimized medium was obtained. The vitamin content of the medium had to be raised significantly. |
| Author | Schrader, J Sell, D Etschmann, M.M.W |
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| Cites_doi | 10.1021/bk-1986-0317.ch002 10.1023/A:1022890119847 10.1017/CBO9780511525421 10.1007/s00253-002-0992-x 10.1007/s004490050651 10.3109/07388559409063643 10.1016/B978-044481312-1/50040-X 10.1016/S1389-1723(01)80027-X 10.1002/bit.10465 |
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| Keywords | Yeast Genetic algorithm Flavor 2-Phenylethanol Fragrance Kluyveromyces Fungi Production Ascomycetes Aroma Optimization Thallophyta |
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| References_xml | – reference: J.C. Lugay, in: T. Parliment, R. Croteau (Eds.), Biogeneration of Aromas, ACS Symposium Series 317, American Chemical Society, Washington, DC, 1986, p. 11. – volume: 119 start-page: 272 year: 1994 ident: BIB5 publication-title: Zuckerindustrie – reference: M.A. Lachance, in: C.P. Kurtzmann, J.W. Fell (Eds.), The Yeasts, a Taxonomic Study, Elsevier, Amsterdam, 1998, p. 227. – volume: 90 start-page: 473 year: 2000 ident: BIB10 publication-title: J. Biosci. Bioeng. – volume: 15 start-page: 37 year: 1990 ident: BIB1 publication-title: Perfum. Flavor. – reference: D.H. Jennings, The Physiology of Fungal Nutrition, Cambridge University Press, Cambridge, UK, 1995, p. 87. – volume: 59 start-page: 1 year: 2002 ident: BIB3 publication-title: Appl. Microb. Biotechnol. – volume: 25 start-page: 531 year: 2003 ident: BIB4 publication-title: Biotechnol. Lett. – volume: 21 start-page: 123 year: 1999 ident: BIB12 publication-title: Bioprocess Eng. – reference: G.M. Walker, Yeast Physiology and Biotechnology, John Wiley & Sons, Chichester, 1998, p. 51. – volume: 14 start-page: 311 year: 1994 ident: BIB8 publication-title: Crit. Rev. Biotechnol. – volume: 81 start-page: 269 year: 2003 ident: BIB11 publication-title: Biotechnol. Bioeng. – volume: 119 start-page: 272 year: 1994 ident: 10.1016/j.molcatb.2003.10.014_BIB5 publication-title: Zuckerindustrie – volume: 15 start-page: 37 year: 1990 ident: 10.1016/j.molcatb.2003.10.014_BIB1 publication-title: Perfum. Flavor. – ident: 10.1016/j.molcatb.2003.10.014_BIB2 doi: 10.1021/bk-1986-0317.ch002 – volume: 25 start-page: 531 year: 2003 ident: 10.1016/j.molcatb.2003.10.014_BIB4 publication-title: Biotechnol. Lett. doi: 10.1023/A:1022890119847 – ident: 10.1016/j.molcatb.2003.10.014_BIB9 doi: 10.1017/CBO9780511525421 – volume: 59 start-page: 1 year: 2002 ident: 10.1016/j.molcatb.2003.10.014_BIB3 publication-title: Appl. Microb. Biotechnol. doi: 10.1007/s00253-002-0992-x – volume: 21 start-page: 123 year: 1999 ident: 10.1016/j.molcatb.2003.10.014_BIB12 publication-title: Bioprocess Eng. doi: 10.1007/s004490050651 – volume: 14 start-page: 311 year: 1994 ident: 10.1016/j.molcatb.2003.10.014_BIB8 publication-title: Crit. Rev. Biotechnol. doi: 10.3109/07388559409063643 – ident: 10.1016/j.molcatb.2003.10.014_BIB6 doi: 10.1016/B978-044481312-1/50040-X – ident: 10.1016/j.molcatb.2003.10.014_BIB7 – volume: 90 start-page: 473 year: 2000 ident: 10.1016/j.molcatb.2003.10.014_BIB10 publication-title: J. Biosci. Bioeng. doi: 10.1016/S1389-1723(01)80027-X – volume: 81 start-page: 269 year: 2003 ident: 10.1016/j.molcatb.2003.10.014_BIB11 publication-title: Biotechnol. Bioeng. doi: 10.1002/bit.10465 |
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| SubjectTerms | 2-Phenylethanol Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Flavor Fragrance Fundamental and applied biological sciences. Psychology Genetic algorithm Kluyveromyces Methods. Procedures. Technologies Yeast |
| Title | Medium optimization for the production of the aroma compound 2-phenylethanol using a genetic algorithm |
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