Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor - Cui, Su-Ying; Yang, Ming-Xin; Zhang, Yong-He; Zheng, Victor; Zhang, Han-Ting; Gurney, Mark E.; Xu, Ying; O’Donnell, James M. (The Journal of pharmacology and experimental therapeutics, 2019)
Keywords: Allosteric Regulation - drug effects; Allosteric Regulation - physiology; Amyloid beta-Peptides - toxicity; Animals; Gene Knock-In Techniques; Hippocampus - drug effects; Hippocampus - pathology; Humans; Memory Disorders - chemically induced; Memory Disorders - pathology; Memory Disorders - prevention & control; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropharmacology; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Peptide Fragments - toxicity; Phosphodiesterase 4 Inhibitors - pharmacology; Phosphodiesterase 4 Inhibitors - therapeutic use; Random Allocation; MWM; ACF; BDNF; hPDE4D; PDE4; PDE4D; H-89; PKA; Aβ; CREB; VGF; pCREB; PSD-95