Biomimetic Nucleation of Manganese Oxide on Silk Fibroin Nanoparticles for Designing Raspberry‐Structured Tumor Environment‐Responsive Anticancer Nanocarriers

Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO 2 ) is responsive to tumor microenvironment (TME). Herein, SF and MnO 2 is integrated to develop novel TME‐responsive drug carriers. Specifically, silk fibroin nanoparticles (SF‐NP...

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Published inAdvanced NanoBiomed Research (Online) Vol. 3; no. 11
Main Authors Wang, Jie, Wang, Yecheng, Chen, Yuping, Lv, Ruyin, Yu, Yanfang, Wang, Junwen, Cheng, Qichao, Shuai, Yajun, Chen, Yuyin, Mao, Chuanbin, Yang, Mingying
Format Journal Article
LanguageEnglish
Published Singapore John Wiley & Sons, Inc 01.11.2023
Wiley-VCH
Subjects
Bioaccumulation
Breast cancer
Cancer therapies
Catalytic activity
Chemotherapy
Drug carriers
Drug delivery
Drug delivery systems
Drugs
Efficiency
Folic acid
Fourier transforms
Hydrogen peroxide
Hypoxia
Lamellar structure
Magnetic resonance imaging
Manganese dioxide
manganese oxide
Manganese oxides
Morphology
Nanoparticles
Nucleation
Oxygen
Photodynamic therapy
Polyethylene glycol
Self-assembly
Silk fibroin
silk fibroin tumor microenvironments
Spectrum analysis
Tumor microenvironment
tumor therapy
Tumors
Online AccessGet full text
ISSN2699-9307
2699-9307
DOI10.1002/anbr.202300056

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Abstract Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO 2 ) is responsive to tumor microenvironment (TME). Herein, SF and MnO 2 is integrated to develop novel TME‐responsive drug carriers. Specifically, silk fibroin nanoparticles (SF‐NPs) are used as a biotemplates to regulate the nucleation and self‐assembly of MnO 2 for designing the complex drug delivery (SM‐NPs). The SM‐NPs are further modified by polyethylene glycol and folic acid to improve their stability and tumor targeting. The resultant nanocarriers (SMPF‐NPs) present a raspberry‐like structure with lamellar MnO 2 nanoparticles coating on its surface. The SMPF‐NPs show a high drug‐loading capability and selectively release drugs in acidic TME. Due to the catalytic activity of MnO 2 , the SMPF‐NPs generate high levels of oxygen under H 2 O 2 and produce more reactive oxygen after loading Ce6. In vivo and in vitro analysis prove that SMPF‐NPs can accumulate in breast tumor tissues, efficiently kill cancer cells, and destroy breast cancer tumors by a combination of chemotherapy and photodynamic therapy (PDT). Moreover, the SMPF‐NPs also provide fluorescence and magnetic resonance (MR) imaging for guiding cancer therapy. These results suggest that the self‐assembled SF and MnO 2 nanocomplex could be a novel TME‐responsive nanodrug delivery system.
AbstractList Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO2) is responsive to tumor microenvironment (TME). Herein, SF and MnO2 is integrated to develop novel TME‐responsive drug carriers. Specifically, silk fibroin nanoparticles (SF‐NPs) are used as a biotemplates to regulate the nucleation and self‐assembly of MnO2 for designing the complex drug delivery (SM‐NPs). The SM‐NPs are further modified by polyethylene glycol and folic acid to improve their stability and tumor targeting. The resultant nanocarriers (SMPF‐NPs) present a raspberry‐like structure with lamellar MnO2 nanoparticles coating on its surface. The SMPF‐NPs show a high drug‐loading capability and selectively release drugs in acidic TME. Due to the catalytic activity of MnO2, the SMPF‐NPs generate high levels of oxygen under H2O2 and produce more reactive oxygen after loading Ce6. In vivo and in vitro analysis prove that SMPF‐NPs can accumulate in breast tumor tissues, efficiently kill cancer cells, and destroy breast cancer tumors by a combination of chemotherapy and photodynamic therapy (PDT). Moreover, the SMPF‐NPs also provide fluorescence and magnetic resonance (MR) imaging for guiding cancer therapy. These results suggest that the self‐assembled SF and MnO2 nanocomplex could be a novel TME‐responsive nanodrug delivery system.
Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO 2 ) is responsive to tumor microenvironment (TME). Herein, SF and MnO 2 is integrated to develop novel TME‐responsive drug carriers. Specifically, silk fibroin nanoparticles (SF‐NPs) are used as a biotemplates to regulate the nucleation and self‐assembly of MnO 2 for designing the complex drug delivery (SM‐NPs). The SM‐NPs are further modified by polyethylene glycol and folic acid to improve their stability and tumor targeting. The resultant nanocarriers (SMPF‐NPs) present a raspberry‐like structure with lamellar MnO 2 nanoparticles coating on its surface. The SMPF‐NPs show a high drug‐loading capability and selectively release drugs in acidic TME. Due to the catalytic activity of MnO 2 , the SMPF‐NPs generate high levels of oxygen under H 2 O 2 and produce more reactive oxygen after loading Ce6. In vivo and in vitro analysis prove that SMPF‐NPs can accumulate in breast tumor tissues, efficiently kill cancer cells, and destroy breast cancer tumors by a combination of chemotherapy and photodynamic therapy (PDT). Moreover, the SMPF‐NPs also provide fluorescence and magnetic resonance (MR) imaging for guiding cancer therapy. These results suggest that the self‐assembled SF and MnO 2 nanocomplex could be a novel TME‐responsive nanodrug delivery system.
Author Yu, Yanfang
Wang, Junwen
Shuai, Yajun
Chen, Yuping
Cheng, Qichao
Yang, Mingying
Chen, Yuyin
Wang, Yecheng
Lv, Ruyin
Mao, Chuanbin
Wang, Jie
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Snippet Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO 2 ) is responsive to tumor...
Bombyx mori silk fibroin is a natural biomacromolecule that can be assembled into nanoparticles. Manganese dioxide (MnO2) is responsive to tumor...
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Aggregation Database
Enrichment Source
Index Database
SubjectTerms Bioaccumulation
Breast cancer
Cancer therapies
Catalytic activity
Chemotherapy
Drug carriers
Drug delivery
Drug delivery systems
Drugs
Efficiency
Folic acid
Fourier transforms
Hydrogen peroxide
Hypoxia
Lamellar structure
Magnetic resonance imaging
Manganese dioxide
manganese oxide
Manganese oxides
Morphology
Nanoparticles
Nucleation
Oxygen
Photodynamic therapy
Polyethylene glycol
Self-assembly
Silk fibroin
silk fibroin tumor microenvironments
Spectrum analysis
Tumor microenvironment
tumor therapy
Tumors
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Title Biomimetic Nucleation of Manganese Oxide on Silk Fibroin Nanoparticles for Designing Raspberry‐Structured Tumor Environment‐Responsive Anticancer Nanocarriers
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