Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects - Toyn, Jeremy H.; Boy, Kenneth M.; Raybon, Joseph; Meredith, Jere E.; Robertson, Alan S.; Guss, Valerie; Hoque, Nina; Sweeney, Francis; Zhuo, Xiaoliang; Clarke, Wendy; Snow, Kimberly; Denton, R. Rex; et al. (The Journal of pharmacology and experimental therapeutics, 2016)
Keywords: Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - genetics; Amyloid Precursor Protein Secretases - metabolism; Aniline Compounds - chemistry; Aniline Compounds - pharmacokinetics; Aniline Compounds - pharmacology; Animals; Brain - drug effects; Brain - enzymology; Brain - metabolism; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - pharmacokinetics; Bridged-Ring Compounds - pharmacology; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Discovery and Translational Medicine; Drug Evaluation, Preclinical; Female; Humans; Macaca fascicularis; Pyrimidines - chemistry; Pyrimidines - pharmacokinetics; Pyrimidines - pharmacology; Rats, Sprague-Dawley; Receptors, Notch - metabolism; Species Specificity; Tissue Distribution; GSM; ABEC; APP; BMS-698861; PK/PD; AD; NSAID; BMS-299897; FAD; BMS-986133; MS-MS; AUC; Aβ; BMS-932481; CSF; GSI; ELISA