Enteral Access Potentially Endangers Esophageal Carcinoma Patients Under Multi-modality Therapy: A Population-based Study

• Published in: Anticancer research Vol. 39; no. 4; pp. 2227 - 2232
• Main Authors: HUANG, CHUN-HOU, HSIEH, TSUNG-CHENG, CHANG, BEE-SONG, WANG, TSO-FU, WU, JUNG-LUN, CHANG, PI-CHUAN, PENG, TAI-CHU
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.04.2019
• Subjects: Adult; Aged; Cancer; Cancer therapies; Chemoradiotherapy; Chronic obstructive pulmonary disease; Cohort analysis; Combined Modality Therapy; Comorbidity; Confounding (Statistics); Digestive System Surgical Procedures; Dysphagia; Enteral Nutrition; Esophageal carcinoma; Esophageal Neoplasms - mortality; Esophageal Neoplasms - therapy; Esophageal Squamous Cell Carcinoma - mortality; Esophageal Squamous Cell Carcinoma - therapy; Esophagus; Female; Hospitals; Humans; Kaplan-Meier Estimate; Lung diseases; Male; Malnutrition; Middle Aged; Mortality; Mortality risk; Nutrition; Nutritional status; Ostomy; Parenteral nutrition; Patients; Population studies; Proportional Hazards Models; Radiation therapy; Retrospective Studies; Risk; Squamous cell carcinoma; Surgery; Survival analysis; Therapy; Toxicity; multi-modality therapy; esophageal cancer; nutritional treatment; Enteral access
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.13338

This study aimed to evaluate the clinical outcome of esophageal cancer (EC) patients with enteral access (EA) undergoing multimodality therapy. This retrospective study analyzed data between 1997 and 2012 in Taiwan using the National Health Insurance Research Database. Patients with newly-diagnosed EC undergoing multimodality therapy were identified and classified as either EA group or no-EA group. The mortality incidence of EC patients with EA was significantly higher than in no-EA patients. The Cox model revealed the EA group had a higher risk of mortality than the no-EA group. Patients with chronic obstructive pulmonary disease (COPD) were at significantly higher risk of mortality compared to patients without COPD. EA in EC patients undergoing multimodality therapy was associated with an increased risk of mortality.