An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion
Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest. Methods: On separate days, fort...
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| Published in | Frontiers in physiology Vol. 13; p. 948087 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
22.07.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-042X 1664-042X |
| DOI | 10.3389/fphys.2022.948087 |
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| Abstract | Introduction:
Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest.
Methods:
On separate days, forty circulatory healthy subjects [aged 60 years (range: 42–75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored.
Results:
Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion.
Conclusion:
PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this. |
|---|---|
| AbstractList | Introduction:
Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest.
Methods:
On separate days, forty circulatory healthy subjects [aged 60 years (range: 42–75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored.
Results:
Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion.
Conclusion:
PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this. Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest. Methods: On separate days, forty circulatory healthy subjects [aged 60 years (range: 42-75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored. Results: Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion. Conclusion: PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this.Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest. Methods: On separate days, forty circulatory healthy subjects [aged 60 years (range: 42-75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored. Results: Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion. Conclusion: PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this. Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest. Methods: On separate days, forty circulatory healthy subjects [aged 60 years (range: 42–75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored. Results: Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion. Conclusion: PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this. Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline infusion and control at rest.Methods: On separate days, forty circulatory healthy subjects [aged 60 years (range: 42–75)] with knee osteoarthritis underwent moderate-high intensity cycling, running, and intravenous adrenaline infusion to mimic the circulatory response to exercise. Blood samples were obtained from peripheral veins taken at several pre-defined time points before, during, and after the interventions. PV changes were estimated using venous hemoglobin and the derived hematocrit. The temporal associations between PV and selected biomarkers were explored.Results: Changes in PV were observed during all four interventions, and the response to cycling and running was similar. Compared to rest, PV decreased by -14.3% (95% CI: -10.0 to -18.7) after cycling, -13.9% (95% CI: -10.9 to -17.0) after running, and -7.8% (95% CI: -4.2 to -11.5) after adrenaline infusion.Conclusion: PV decreased in response to moderate-high intensity running and cycling. Adrenaline infusion mimicked the PV change observed during exercise, suggesting a separate influence of autonomic control on blood volume homeostasis. In perspective, a temporal association between PV and biomarker dynamics suggests that consideration of PV changes could be relevant when reporting plasma/serum constituents measured during exercise, but more research is needed to confirm this. |
| Author | Bjerre-Bastos, Jonathan J. Bihlet, Asger R. Kitchen, Carl-Christian Sejersen, Casper Nielsen, Henning Bay Secher, Niels H. Drobinski, Patryk Thudium, Christian S. Mackey, Abigail L. |
| AuthorAffiliation | 5 Nordic Bioscience , Herlev , Denmark 6 Department of Anesthesiology, Roskilde Hospital , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark 2 NBCD A/S , Herlev , Denmark 7 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen , Copenhagen , Denmark 3 Department of Anesthesia, Rigshospitalet , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark 4 Institute of Sports Medicine, Bispebjerg Hospital , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark 1 Xlab , Department of Biomedical Sciences , Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark |
| AuthorAffiliation_xml | – name: 3 Department of Anesthesia, Rigshospitalet , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark – name: 7 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen , Copenhagen , Denmark – name: 2 NBCD A/S , Herlev , Denmark – name: 6 Department of Anesthesiology, Roskilde Hospital , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark – name: 5 Nordic Bioscience , Herlev , Denmark – name: 4 Institute of Sports Medicine, Bispebjerg Hospital , Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark – name: 1 Xlab , Department of Biomedical Sciences , Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark |
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| CitedBy_id | crossref_primary_10_1016_j_ocarto_2023_100390 crossref_primary_10_1073_pnas_2406954122 |
| Cites_doi | 10.1046/j.1532-5415.2001.00496.x 10.1111/j.1475-097X.1991.tb00813.x 10.1016/j.joca.2021.02.569 10.1172/jci101165 10.1152/jappl.1978.45.3.414 10.1080/02701367.1982.10605252 10.1152/ajpheart.1986.250.1.h68 10.1152/jappl.1973.34.1.102 10.1002/tsm2.155 10.1152/ajpregu.1998.274.1.r126 10.3109/00365519009087494 10.1007/s00421-021-04751-z 10.1016/j.joca.2019.11.007 10.1007/s00421-019-04232-4 10.1055/s-2008-1026093 10.1038/s41598-022-10310-z 10.1042/cs0770149 10.1016/j.joca.2022.02.121 10.1186/1471-2474-7-98 10.1111/sms.12393 10.3390/medsci5030015 10.1519/JSC.0b013e318282d416 10.1172/jci100859 10.1007/BF00421753 10.3389/fphys.2017.00661 10.1016/j.joca.2022.02.129 |
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| Copyright | Copyright © 2022 Bjerre-Bastos, Sejersen, Bihlet, Secher, Mackey, Kitchen, Drobinski, Thudium and Nielsen. Copyright © 2022 Bjerre-Bastos, Sejersen, Bihlet, Secher, Mackey, Kitchen, Drobinski, Thudium and Nielsen. 2022 Bjerre-Bastos, Sejersen, Bihlet, Secher, Mackey, Kitchen, Drobinski, Thudium and Nielsen |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Alexander E. Berezin, Zaporizhia State Medical University, Ukraine This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology ORCID: Jonathan J. Bjerre-Bastos, 0000-0002-6477-3219; Casper Sejersen, 0000-0002-6929-0072; Asger R. Bihlet, 0000-0002-6944-1731; Henning Bay Nielsen, 0000-0003-3533-8098; Abigail L. Mackey, 0000-0002-2017-4580; Carl-Christian Kitchen, 0000-0002-8520-3522 Edited by: Johannes Van Lieshout, University of Amsterdam, Netherlands Agnaldo Bruno Chies, Faculdade de Medicina de Marília, Brazil |
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| Snippet | Introduction:
Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in... Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in... |
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| SubjectTerms | adrenaline biomarkers cycling exercise Physiology plasma volume change running |
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| Title | An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion |
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