Population pharmacokinetics of sonidegib (LDE225), an oral inhibitor of hedgehog pathway signaling, in healthy subjects and in patients with advanced solid tumors - Goel, Varun; Hurh, Eunju; Stein, Andrew; Nedelman, Jerry; Zhou, Jocelyn; Chiparus, Ovidiu; Huang, Pai-Hsi; Gogov, Sven; Sellami, Dalila (Cancer chemotherapy and pharmacology, 2016)
Keywords: Administration, Oral; Adult; Aged; Aged, 80 and over; Biphenyl Compounds - pharmacokinetics; Cancer Research; Female; Hedgehog Proteins - antagonists & inhibitors; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Oncology; Original Article; Pharmacology/Toxicology; Pyridines - pharmacokinetics; Signal Transduction - drug effects; Basal cell carcinoma; Food effect; Sonidegib; Solid tumors; Bioavailability; Pharmacokinetics; Modeling