Neuregulin 3 and Erbb Signalling Networks in Embryonic Mammary Gland Development

• Published in: Journal of mammary gland biology and neoplasia Vol. 18; no. 2; pp. 149 - 154
• Main Authors: Kogata, Naoko, Zvelebil, Marketa, Howard, Beatrice A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2013; Springer Nature B.V
• Subjects: Animals; Cancer Research; Cell fate; Developmental stages; Embryogenesis; ErbB protein; Female; Gene Expression Regulation, Developmental; Growth factors; Humans; Mammary gland; Mammary Glands, Animal - embryology; Mammary Glands, Animal - metabolism; Mammary Glands, Human - embryology; Mammary Glands, Human - metabolism; Medicine; Medicine & Public Health; Neuregulin; Neuregulins - genetics; Neuregulins - metabolism; Oncogene Proteins v-erbB - genetics; Oncogene Proteins v-erbB - metabolism; Oncology; Signal Transduction; Mammary primordium; Neuregulin 3 (Nrg3); Erbb4; Network
• ISSN: 1083-3021; 1573-7039; 1573-7039
• DOI: 10.1007/s10911-013-9286-4

We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.