QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization - Keirns, J; Desai, A; Kowalski, D; Lademacher, C; Mujais, S; Parker, B; Schneidkraut, MJ; Townsend, R; Wojtkowski, T; Yamazaki, T; Yen, M; Kowey, PR (Clinical pharmacology and therapeutics, 2017)
Keywords: Action Potentials - drug effects; Adult; Antifungal Agents - adverse effects; Antifungal Agents - pharmacokinetics; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - physiopathology; Calcium Channel Blockers - adverse effects; Calcium Channel Blockers - pharmacokinetics; Calcium Channels, L-Type - drug effects; Calcium Channels, L-Type - metabolism; Cell Line; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Conduction System - drug effects; Heart Conduction System - metabolism; Heart Conduction System - physiopathology; Heart Rate - drug effects; Humans; Male; Models, Biological; Nitriles - adverse effects; Nitriles - pharmacokinetics; Pyridines - adverse effects; Pyridines - pharmacokinetics; Risk Assessment; Time Factors; Transfection; Triazoles - adverse effects; Triazoles - pharmacokinetics; Young Adult