Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes
: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction...
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| Published in | Biomarkers in medicine Vol. 13; no. 9; pp. 737 - 750 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.06.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1752-0363 1752-0371 1752-0371 |
| DOI | 10.2217/bmm-2018-0449 |
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| Abstract | : to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF).
The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline.
The number of circulating CD31
/annexin V
MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144
/annexin V
MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31
/annexin V
MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144
/annexin V
MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF.
We found that the number of circulating CD31
/annexin V
MVs may improve a predictive capacity for conventional HF biomarkers. |
|---|---|
| AbstractList | Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. Results: The number of circulating CD31+/annexin V+ MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144+/annexin V+ MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31+/annexin V+ MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144+/annexin V+ MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. Conclusion: We found that the number of circulating CD31+/annexin V+ MVs may improve a predictive capacity for conventional HF biomarkers. Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. Results: The number of circulating CD31+/annexin V+ MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144+/annexin V+ MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31+/annexin V+ MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144+/annexin V+ MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. Conclusion: We found that the number of circulating CD31+/annexin V+ MVs may improve a predictive capacity for conventional HF biomarkers.Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. Results: The number of circulating CD31+/annexin V+ MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144+/annexin V+ MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31+/annexin V+ MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144+/annexin V+ MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. Conclusion: We found that the number of circulating CD31+/annexin V+ MVs may improve a predictive capacity for conventional HF biomarkers. : to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. The number of circulating CD31 /annexin V MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144 /annexin V MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31 /annexin V MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144 /annexin V MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. We found that the number of circulating CD31 /annexin V MVs may improve a predictive capacity for conventional HF biomarkers. |
| Author | Kremzer, Alexander A Berezina, Tatyana A Berezin, Alexander E Samura, Tatyana A |
| AuthorAffiliation | 3Private Medical Center ‘Vita-Center’, Zaporozhye, 69000, Ukraine 1Internal Medicine Department, State Medical University, Zaporozhye, 69035, Ukraine 2Clinical Pharmacology Department, State Medical University, Zaporozhye, 69035, Ukraine |
| AuthorAffiliation_xml | – name: 1Internal Medicine Department, State Medical University, Zaporozhye, 69035, Ukraine – name: 2Clinical Pharmacology Department, State Medical University, Zaporozhye, 69035, Ukraine – name: 3Private Medical Center ‘Vita-Center’, Zaporozhye, 69000, Ukraine |
| Author_xml | – sequence: 1 givenname: Alexander E surname: Berezin fullname: Berezin, Alexander E organization: Internal Medicine Department, State Medical University, Zaporozhye, 69035, Ukraine – sequence: 2 givenname: Alexander A surname: Kremzer fullname: Kremzer, Alexander A organization: Clinical Pharmacology Department, State Medical University, Zaporozhye, 69035, Ukraine – sequence: 3 givenname: Tatyana A surname: Samura fullname: Samura, Tatyana A organization: Clinical Pharmacology Department, State Medical University, Zaporozhye, 69035, Ukraine – sequence: 4 givenname: Tatyana A surname: Berezina fullname: Berezina, Tatyana A organization: Private Medical Center ‘Vita-Center’, Zaporozhye, 69000, Ukraine |
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| Keywords | natriuretic peptides endothelial cell-derived microvesicles chronic heart failure soluble suppressor of tumorogenicity-2 galectin-3 biomarkers |
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| Snippet | : to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF).
The... Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF).... |
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| SubjectTerms | Annexin A5 - blood Annexin V Antigens, CD - blood Apoptosis Biomarkers Biomarkers - blood Cadherins - blood Cardiovascular disease Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology chronic heart failure Clinical outcomes Cohort Studies Collaboration Congestive heart failure Diabetes endothelial cell-derived microvesicles Endothelial cells Endothelial Cells - pathology Endothelium Extracellular Vesicles - pathology Female Galectin 3 - blood galectin-3 Heart attacks Heart failure Heart Failure - blood Heart Failure - physiopathology Hospitals Humans Hypertension Inflammation Interleukin-1 Receptor-Like 1 Protein - blood Kidney diseases Male Middle Aged Natriuretic Peptide, Brain - blood natriuretic peptides Peptide Fragments - blood Peptides Phenotype Phenotypes Platelet Endothelial Cell Adhesion Molecule-1 - blood Prospective Studies soluble suppressor of tumorogenicity-2 Stroke Volume Studies Ultrasonic imaging Ventricle Ventricular Remodeling |
| Title | Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes |
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