Analysis of microRNA expression and micronuclei frequency in workers exposed to vinyl chloride monomer in China
To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency. In discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative expos...
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| Published in | Epigenomics Vol. 9; no. 8; pp. 1093 - 1104 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.08.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1750-1911 1750-192X 1750-192X |
| DOI | 10.2217/epi-2017-0028 |
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| Abstract | To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.
In discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative exposure dose. Then we validated four miRNAs using real-time quantitative reverse transcription PCR (qRT-PCR) and detected the micronuclei frequencies using cytokinesis-block micronucleus assay in 94 VCM-exposed workers and 53 healthy control subjects.
We found eight miRNAs significantly downregulated and seven miRNAs upregulated (|Fold Change| >2; p < 0.05) in the high-exposure group through microarray. We validate that miR-222-3p, miR-146a-5p and miR-151a-5p were downregulated, while miR-22-3p was upregulated in VCM-exposed group (all p < 0.01). Furthermore, we found that expression of miR-22-3p was upregulated in the high micronuclei (MN) frequency subjects. In conclusion, our study suggested that these four miRNAs could be biomarkers of VCM exposure, and moreover miR-22-3p was correlated with MN frequency. |
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| AbstractList | To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.
In discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative exposure dose. Then we validated four miRNAs using real-time quantitative reverse transcription PCR (qRT-PCR) and detected the micronuclei frequencies using cytokinesis-block micronucleus assay in 94 VCM-exposed workers and 53 healthy control subjects.
We found eight miRNAs significantly downregulated and seven miRNAs upregulated (|Fold Change| >2; p < 0.05) in the high-exposure group through microarray. We validate that miR-222-3p, miR-146a-5p and miR-151a-5p were downregulated, while miR-22-3p was upregulated in VCM-exposed group (all p < 0.01). Furthermore, we found that expression of miR-22-3p was upregulated in the high micronuclei (MN) frequency subjects. In conclusion, our study suggested that these four miRNAs could be biomarkers of VCM exposure, and moreover miR-22-3p was correlated with MN frequency. Aim: To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency. Method: In discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative exposure dose. Then we validated four miRNAs using real-time quantitative reverse transcription PCR (qRT-PCR) and detected the micronuclei frequencies using cytokinesis-block micronucleus assay in 94 VCM-exposed workers and 53 healthy control subjects. Results & conclusion: We found eight miRNAs significantly downregulated and seven miRNAs upregulated (|Fold Change| >2; p < 0.05) in the high-exposure group through microarray. We validate that miR-222–3p, miR-146a-5p and miR-151a-5p were downregulated, while miR-22–3p was upregulated in VCM-exposed group (all p < 0.01). Furthermore, we found that expression of miR-22-3p was upregulated in the high micronuclei (MN) frequency subjects. In conclusion, our study suggested that these four miRNAs could be biomarkers of VCM exposure, and moreover miR-22–3p was correlated with MN frequency. To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.AIMTo identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.In discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative exposure dose. Then we validated four miRNAs using real-time quantitative reverse transcription PCR (qRT-PCR) and detected the micronuclei frequencies using cytokinesis-block micronucleus assay in 94 VCM-exposed workers and 53 healthy control subjects.METHODIn discovery stage, we used microarray to detect miRNAs expression in peripheral blood lymphocytes between six low and six high VCM-exposed workers grouped by medium cumulative exposure dose. Then we validated four miRNAs using real-time quantitative reverse transcription PCR (qRT-PCR) and detected the micronuclei frequencies using cytokinesis-block micronucleus assay in 94 VCM-exposed workers and 53 healthy control subjects.We found eight miRNAs significantly downregulated and seven miRNAs upregulated (|Fold Change| >2; p < 0.05) in the high-exposure group through microarray. We validate that miR-222-3p, miR-146a-5p and miR-151a-5p were downregulated, while miR-22-3p was upregulated in VCM-exposed group (all p < 0.01). Furthermore, we found that expression of miR-22-3p was upregulated in the high micronuclei (MN) frequency subjects. In conclusion, our study suggested that these four miRNAs could be biomarkers of VCM exposure, and moreover miR-22-3p was correlated with MN frequency.RESULTS & CONCLUSIONWe found eight miRNAs significantly downregulated and seven miRNAs upregulated (|Fold Change| >2; p < 0.05) in the high-exposure group through microarray. We validate that miR-222-3p, miR-146a-5p and miR-151a-5p were downregulated, while miR-22-3p was upregulated in VCM-exposed group (all p < 0.01). Furthermore, we found that expression of miR-22-3p was upregulated in the high micronuclei (MN) frequency subjects. In conclusion, our study suggested that these four miRNAs could be biomarkers of VCM exposure, and moreover miR-22-3p was correlated with MN frequency. |
| Author | Xu, Xiao-wen Xia, Zhao-lin Brandt-Rauf, Paul Zhang, Ya-nan Feng, Nan-nan Li, Yong Wang, Jin-wei Li, Yong-liang Fang, Yan |
| AuthorAffiliation | 2Hongqiao International Institute of Medicine, Shanghai Tongren Hospital & Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 3Department of Environmental & Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA 1Department of Occupational Health & Toxicology, School of Public Health, Fudan University, & Key Laboratory of Public Health & Safety of Ministry of Education of China, Shanghai, 200032, China |
| AuthorAffiliation_xml | – name: 1Department of Occupational Health & Toxicology, School of Public Health, Fudan University, & Key Laboratory of Public Health & Safety of Ministry of Education of China, Shanghai, 200032, China – name: 2Hongqiao International Institute of Medicine, Shanghai Tongren Hospital & Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China – name: 3Department of Environmental & Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA |
| Author_xml | – sequence: 1 givenname: Nan-nan surname: Feng fullname: Feng, Nan-nan – sequence: 2 givenname: Yan surname: Fang fullname: Fang, Yan – sequence: 3 givenname: Ya-nan surname: Zhang fullname: Zhang, Ya-nan – sequence: 4 givenname: Xiao-wen surname: Xu fullname: Xu, Xiao-wen – sequence: 5 givenname: Yong surname: Li fullname: Li, Yong – sequence: 6 givenname: Jin-wei surname: Wang fullname: Wang, Jin-wei – sequence: 7 givenname: Yong-liang surname: Li fullname: Li, Yong-liang – sequence: 8 givenname: Paul surname: Brandt-Rauf fullname: Brandt-Rauf, Paul – sequence: 9 givenname: Zhao-lin surname: Xia fullname: Xia, Zhao-lin |
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| CitedBy_id | crossref_primary_10_1080_1354750X_2019_1652348 crossref_primary_10_1016_j_mrrev_2021_108408 |
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| Snippet | To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.
In discovery stage, we used microarray to... Aim: To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency. Method: In discovery stage, we used... To identify differently expressed miRNAs associated with vinyl chloride monomer (VCM) and micronuclei (MN) frequency.AIMTo identify differently expressed... |
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| SubjectTerms | Adult Biomarkers Breast cancer Case-Control Studies Chemical Industry China chromosomal damage Cytokinesis Deoxyribonucleic acid DNA DNA damage DNA microarrays DNA repair Exposure Family medical history Female Gene expression Health care Humans Lymphocytes Male Micronuclei Micronuclei, Chromosome-Defective - chemically induced Micronuclei, Chromosome-Defective - statistics & numerical data MicroRNAs MicroRNAs - genetics miRNA miRNAs Monomers Occupational exposure Occupational Exposure - adverse effects Peripheral blood Polycyclic aromatic hydrocarbons Polymerization Polyvinyl chloride Prostate Reverse transcription Ribonucleic acid RNA Tumorigenesis Vinyl chloride Vinyl Chloride - toxicity Workers |
| Title | Analysis of microRNA expression and micronuclei frequency in workers exposed to vinyl chloride monomer in China |
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