Efficacy of Intravenous Itraconazole Versus Liposomal Amphotericin B as Empirical Antifungal Therapy in Hematological Malignancy with Persistent Fever and Neutropenia: Study Protocol for a Multicenter, Prospective, Randomized Non-inferiority Trial - SAWAMURA, MORIO; TANAKA, SHIRO; HIDAKA, MICHIHIRO; YOSHIDA, ISAO; SAITO, AKIKO M; UIKE, NAOKUNI; KANEKO, YUKIHIRO; MIYAZAKI, YOSHITSUGU; NAGAI, HIROKAZU; YOSHIDA, SHINICHIRO (Kurume medical journal, 2019)
Keywords: Amphotericin B - administration & dosage; Amphotericin B - adverse effects; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Equivalence Trials as Topic; febrile neutropenia; Fever of Unknown Origin - drug therapy; fungal infection; Hematologic Neoplasms - complications; Hematologic Neoplasms - drug therapy; hematological malignancy; Humans; intravenous itraconazole; Itraconazole - administration & dosage; Itraconazole - adverse effects; liposomal amphotericin B; Multicenter Studies as Topic; Neutropenia - drug therapy; Prospective Studies; Randomized Controlled Trials as Topic; liposomal amphotericin B; fungal infection; febrile neutropenia; hematological malignancy; intravenous itraconazole