Chinese Medicine Improves Postoperative Quality of Life in Endometriosis Patients： A Randomized Controlled Trial

• Published in: Chinese journal of integrative medicine Vol. 19; no. 1; pp. 15 - 21
• Main Author: 赵瑞华 刘永 谈勇 郝增平 盂庆伟 王蕊 龙棣 丁永芬 宋殿荣 徐彩 任志珍 杨艳环 王蔼明
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Association of Traditional and Western Medicine 2013
• Subjects: Adolescent; Adult; China; Drugs, Chinese Herbal - therapeutic use; Endometriosis - diagnosis; Endometriosis - surgery; Female; Follow-Up Studies; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gonadotropin-Releasing Hormone - therapeutic use; Humans; Medicine; Medicine & Public Health; Middle Aged; Original Article; Pain Measurement; Pain, Postoperative - drug therapy; Pain, Postoperative - physiopathology; Patient Satisfaction - statistics & numerical data; Postoperative Care - methods; Prospective Studies; Quality of Life; Reference Values; Risk Assessment; Treatment Outcome; Young Adult; 中国医药; 促性腺激素释放激素; 子宫内膜异位症; 患者; 生活质量; 结合治疗; 评分系统; 随机对照试验; China; endometriosis; Chinese medicine; gonadotropin-releasing hormone agonist; World Health Organization QOL-BREF; quality of life
• ISSN: 1672-0415; 1993-0402; 1993-0402
• DOI: 10.1007/s11655-012-1196-6

Objective： To investigate the effect of Chinese medicine （CM） and Western medicine （WM） on quality of life （QOL） after conservative surgery for endometriosis. Methods： A total of 320 patients with endometdosis were randomized into two groups by using random block design, CM group （160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation） and WM group （160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment） after conservative surgery. Treatment was given for 3-6 months （according to the revised American Fertility Society scoring system stage）, and the Wodd Health Organization QOL-BREF （WHOQOL-BREF） was applied to patients before and after treatment to assess QOL. Results： There were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores post- treatment were significantly higher than those at pre-treatment （P〈0.05）, and for 12 items （pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care： accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL）, the difference in scores was significant （P〈0.05）. In the WM group, 4 items （pain and discomfort, opportunities for acquiring new information and skills, QOI_ score, overall health status and QOL） had significantly different scores post-treatment compared with those at pre-treatment （P〈0.05）. Before treatment, the QOL in the two groups of patients showed no significant difference （P〉0.05）. After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group （P〈0.05） and the scores of 4 items （mobility, activities of daily living, sexual activity, QOL score） in the CM group were significantly higher than those in the WM group （P〈0.05）. Conclusions： CM and WM treatment could improve the QOL of patients with endometriosis after conservative surgery. CM treatment is more effective than WM.