Human Biodistribution and Dosimetry of the PET Radioligand [11C]Flumazenil (FMZ)
Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures After injection with 770 MBq of [ 11 C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET sc...
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Published in | Molecular imaging and biology Vol. 14; no. 1; pp. 115 - 122 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer-Verlag
01.02.2012
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
ISSN | 1536-1632 1860-2002 |
DOI | 10.1007/s11307-011-0478-2 |
Cover
Abstract | Purpose
We measure the whole-body distribution of IV injected [
11
C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses.
Procedures
After injection with 770 MBq of [
11
C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027,
2005
) was used to perform dosimetry calculations for the various body organs and for the whole body.
Results
For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10
−3
mSv/MBq of injected [
11
C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10
−3
and 1.12 × 10
−2
mSv MBq
−1
, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10
−2
mSv MBq
−1
.
Conclusion
On average, the administration of less than 790 MBq (21 mCi) of [
11
C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit. |
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AbstractList | We measure the whole-body distribution of IV injected [^sup 11^C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. After injection with 770 MBq of [^sup 11^C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. For the no voiding situation, the average whole-body radiation equivalent dose was 3.02×10^sup -3^ mSv/MBq of injected [^sup 11^C]FMZ. The average effective dose and effective dose equivalent was 7.57×10^sup -3^ and 1.12×10^sup -2^ mSv MBq^sup -1^, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32×10^sup -2^ mSv MBq^sup -1^. On average, the administration of less than 790 MBq (21 mCi) of [^sup 11^C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.[PUBLICATION ABSTRACT] Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures After injection with 770 MBq of [ 11 C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005 ) was used to perform dosimetry calculations for the various body organs and for the whole body. Results For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10 −3 mSv/MBq of injected [ 11 C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10 −3 and 1.12 × 10 −2 mSv MBq −1 , respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10 −2 mSv MBq −1 . Conclusion On average, the administration of less than 790 MBq (21 mCi) of [ 11 C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit. Purpose: We measure the whole-body distribution of IV injected [ super(11)C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures: After injection with 770 MBq of [ super(11)C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. Results: For the no voiding situation, the average whole-body radiation equivalent dose was 3.0210 super(-3) mSv/MBq of injected [ super(11)C]FMZ. The average effective dose and effective dose equivalent was 7.5710 super(-3) and 1.1210 super(-2) mSv MBq super(-1), respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.3210 super(-2) mSv MBq super(-1). Conclusion: On average, the administration of less than 790 MBq (21 mCi) of [ super(11)C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit. We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. After injection with 770 MBq of [¹¹C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10⁻³ mSv/MBq of injected [¹¹C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10⁻³ and 1.12 × 10⁻² mSv MBq⁻¹, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10⁻² mSv MBq⁻¹. On average, the administration of less than 790 MBq (21 mCi) of [¹¹C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit. |
Author | Carney, Jonathan P. Laymon, Charles M. Narendran, Rajesh Lopresti, Brian J. Frankle, W. Gordan Sashin, Donald Mason, Neale S. Mathis, Chester A. Mountz, James M. |
Author_xml | – sequence: 1 givenname: Charles M. surname: Laymon fullname: Laymon, Charles M. email: CML14@pitt.edu organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 2 givenname: Rajesh surname: Narendran fullname: Narendran, Rajesh organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 3 givenname: Neale S. surname: Mason fullname: Mason, Neale S. organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 4 givenname: Jonathan P. surname: Carney fullname: Carney, Jonathan P. organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 5 givenname: Brian J. surname: Lopresti fullname: Lopresti, Brian J. organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 6 givenname: Chester A. surname: Mathis fullname: Mathis, Chester A. organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 7 givenname: James M. surname: Mountz fullname: Mountz, James M. organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 8 givenname: Donald surname: Sashin fullname: Sashin, Donald organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh – sequence: 9 givenname: W. Gordan surname: Frankle fullname: Frankle, W. Gordan organization: Department of Psychiatry, Western Psychiatric Institute, University of Pittsburgh |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21365327$$D View this record in MEDLINE/PubMed |
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Keywords | C]Flumazenil Biodistributiom Dosimetry [ Positron emission tomography |
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We measure the whole-body distribution of IV injected [
11
C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed... We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses.... We measure the whole-body distribution of IV injected [^sup 11^C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation... Purpose: We measure the whole-body distribution of IV injected [ super(11)C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed... |
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SubjectTerms | Adult Blood Carbon Radioisotopes - chemistry Carbon Radioisotopes - pharmacokinetics Dosimetry Eye lens Female Flumazenil - chemistry Flumazenil - pharmacokinetics Gonads Humans Imaging Male Medicine Medicine & Public Health Positron-Emission Tomography - methods Radiation Radiation Dosage Radioisotopes Radiology Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Research Article Tissue Distribution Urinary bladder Whole Body Imaging - methods |
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Title | Human Biodistribution and Dosimetry of the PET Radioligand [11C]Flumazenil (FMZ) |
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