Human Biodistribution and Dosimetry of the PET Radioligand [11C]Flumazenil (FMZ)

Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures After injection with 770 MBq of [ 11 C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET sc...

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Published inMolecular imaging and biology Vol. 14; no. 1; pp. 115 - 122
Main Authors Laymon, Charles M., Narendran, Rajesh, Mason, Neale S., Carney, Jonathan P., Lopresti, Brian J., Mathis, Chester A., Mountz, James M., Sashin, Donald, Frankle, W. Gordan
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.02.2012
Springer Nature B.V
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Online AccessGet full text
ISSN1536-1632
1860-2002
DOI10.1007/s11307-011-0478-2

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Abstract Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures After injection with 770 MBq of [ 11 C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005 ) was used to perform dosimetry calculations for the various body organs and for the whole body. Results For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10 −3  mSv/MBq of injected [ 11 C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10 −3 and 1.12 × 10 −2  mSv MBq −1 , respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10 −2  mSv MBq −1 . Conclusion On average, the administration of less than 790 MBq (21 mCi) of [ 11 C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.
AbstractList We measure the whole-body distribution of IV injected [^sup 11^C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. After injection with 770 MBq of [^sup 11^C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. For the no voiding situation, the average whole-body radiation equivalent dose was 3.02×10^sup -3^ mSv/MBq of injected [^sup 11^C]FMZ. The average effective dose and effective dose equivalent was 7.57×10^sup -3^ and 1.12×10^sup -2^ mSv MBq^sup -1^, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32×10^sup -2^ mSv MBq^sup -1^. On average, the administration of less than 790 MBq (21 mCi) of [^sup 11^C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.[PUBLICATION ABSTRACT]
Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures After injection with 770 MBq of [ 11 C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005 ) was used to perform dosimetry calculations for the various body organs and for the whole body. Results For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10 −3  mSv/MBq of injected [ 11 C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10 −3 and 1.12 × 10 −2  mSv MBq −1 , respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10 −2  mSv MBq −1 . Conclusion On average, the administration of less than 790 MBq (21 mCi) of [ 11 C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.
Purpose: We measure the whole-body distribution of IV injected [ super(11)C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. Procedures: After injection with 770 MBq of [ super(11)C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. Results: For the no voiding situation, the average whole-body radiation equivalent dose was 3.0210 super(-3) mSv/MBq of injected [ super(11)C]FMZ. The average effective dose and effective dose equivalent was 7.5710 super(-3) and 1.1210 super(-2) mSv MBq super(-1), respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.3210 super(-2) mSv MBq super(-1). Conclusion: On average, the administration of less than 790 MBq (21 mCi) of [ super(11)C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.
We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses. After injection with 770 MBq of [¹¹C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body. For the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10⁻³ mSv/MBq of injected [¹¹C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10⁻³ and 1.12 × 10⁻² mSv MBq⁻¹, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10⁻² mSv MBq⁻¹. On average, the administration of less than 790 MBq (21 mCi) of [¹¹C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.
Author Carney, Jonathan P.
Laymon, Charles M.
Narendran, Rajesh
Lopresti, Brian J.
Frankle, W. Gordan
Sashin, Donald
Mason, Neale S.
Mathis, Chester A.
Mountz, James M.
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– sequence: 2
  givenname: Rajesh
  surname: Narendran
  fullname: Narendran, Rajesh
  organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh
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  surname: Mason
  fullname: Mason, Neale S.
  organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh
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  surname: Carney
  fullname: Carney, Jonathan P.
  organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh
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  surname: Lopresti
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  fullname: Sashin, Donald
  organization: Department of Radiology, UPMC/Presbyterian Hospital, University of Pittsburgh
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  givenname: W. Gordan
  surname: Frankle
  fullname: Frankle, W. Gordan
  organization: Department of Psychiatry, Western Psychiatric Institute, University of Pittsburgh
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21365327$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1186_s41181_020_00110_z
crossref_primary_10_1016_S1634_7072_15_70502_7
crossref_primary_10_1007_s00259_024_07046_5
crossref_primary_10_2967_jnumed_120_257402
crossref_primary_10_1007_s11307_014_0820_6
crossref_primary_10_2967_jnumed_111_094565
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World Molecular Imaging Society 2012
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Keywords C]Flumazenil
Biodistributiom
Dosimetry
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Positron emission tomography
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Snippet Purpose We measure the whole-body distribution of IV injected [ 11 C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed...
We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses....
We measure the whole-body distribution of IV injected [^sup 11^C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation...
Purpose: We measure the whole-body distribution of IV injected [ super(11)C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed...
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SubjectTerms Adult
Blood
Carbon Radioisotopes - chemistry
Carbon Radioisotopes - pharmacokinetics
Dosimetry
Eye lens
Female
Flumazenil - chemistry
Flumazenil - pharmacokinetics
Gonads
Humans
Imaging
Male
Medicine
Medicine & Public Health
Positron-Emission Tomography - methods
Radiation
Radiation Dosage
Radioisotopes
Radiology
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - pharmacokinetics
Research Article
Tissue Distribution
Urinary bladder
Whole Body Imaging - methods
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Title Human Biodistribution and Dosimetry of the PET Radioligand [11C]Flumazenil (FMZ)
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