Pulsed infrared light therapy does not increase nitric oxide concentration in the blood of patients with type 1 and type 2 diabetes mellitus

The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neurop...

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Published in	Acta diabetologica Vol. 46; no. 3; pp. 233 - 237
Main Authors	Arnall, David Alan, Nelson, Arnold G., Stambaugh, Laura, Sanz Sevilla, Núria, Cebrià i Iranzo, M. Àngels, López Bueno, Laura, Sanz, Isabel, Arnall, Sheridan B.
Format	Journal Article
Language	English
Published	Milan Springer Milan 01.09.2009 Springer Nature B.V
Subjects	Adult Aged Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - therapy Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Diabetic neuropathy Female Foot - radiation effects Humans Infrared radiation Infrared Rays - therapeutic use Internal Medicine Light therapy Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Nitric oxide Nitric Oxide - blood Original Article Peripheral Nervous System Diseases - therapy Phototherapy - methods Infrared light modality PILT Type 2 diabetes mellitus Infrared light Peripheral neuropathy Peripheral protective sensation Physical therapy Type 1 diabetes mellitus
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ISSN	0940-5429 1432-5233 1432-5233
DOI	10.1007/s00592-008-0082-3

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Abstract	The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 ( N = 2) or type 2 ( N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration . Contrary to the popular supposition, PILT treatments actually resulted in a significantly ( P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production.
AbstractList	The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 ( N = 2) or type 2 ( N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration . Contrary to the popular supposition, PILT treatments actually resulted in a significantly ( P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production. The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 (N = 2) or type 2 (N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration. Contrary to the popular supposition, PILT treatments actually resulted in a significantly (P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production. [PUBLICATION ABSTRACT] The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 (N = 2) or type 2 (N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration. Contrary to the popular supposition, PILT treatments actually resulted in a significantly (P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production. The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 (N = 2) or type 2 (N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration. Contrary to the popular supposition, PILT treatments actually resulted in a significantly (P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production.The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 (N = 2) or type 2 (N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and experimental feet and were later analyzed for NO concentration. Contrary to the popular supposition, PILT treatments actually resulted in a significantly (P < 0.05) decreased concentration of NO. Additionally, there were no significant differences between the treated and untreated feet. Since in individuals where PILT has significantly improved PPS, PILT did not stimulate an increased NO content in the blood, it appears that infrared light improves peripheral protective sensation in patients by a mechanism other than an increased NO production.
Author	Sanz Sevilla, Núria Cebrià i Iranzo, M. Àngels Stambaugh, Laura Nelson, Arnold G. Arnall, David Alan Sanz, Isabel López Bueno, Laura Arnall, Sheridan B.
Author_xml	– sequence: 1 givenname: David Alan surname: Arnall fullname: Arnall, David Alan email: Arnall@etsu.edu, ARNALL@mail.etsu.edu organization: Physical Therapy Department, East Tennessee State University – sequence: 2 givenname: Arnold G. surname: Nelson fullname: Nelson, Arnold G. organization: Department of Kinesiology, Louisiana State University – sequence: 3 givenname: Laura surname: Stambaugh fullname: Stambaugh, Laura organization: GE Analytical Instruments – sequence: 4 givenname: Núria surname: Sanz Sevilla fullname: Sanz Sevilla, Núria organization: Departamento de Fisioterapia, Universitat de València – sequence: 5 givenname: M. Àngels surname: Cebrià i Iranzo fullname: Cebrià i Iranzo, M. Àngels organization: Departamento de Fisioterapia, Universitat de València – sequence: 6 givenname: Laura surname: López Bueno fullname: López Bueno, Laura organization: Departamento de Fisioterapia, Universitat de València – sequence: 7 givenname: Isabel surname: Sanz fullname: Sanz, Isabel organization: Hospital Clínico Universitario de Valencia – sequence: 8 givenname: Sheridan B. surname: Arnall fullname: Arnall, Sheridan B.
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Keywords	Infrared light modality PILT Type 2 diabetes mellitus Infrared light Peripheral neuropathy Peripheral protective sensation Physical therapy Type 1 diabetes mellitus
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SubjectTerms	Adult Aged Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - therapy Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Diabetic neuropathy Female Foot - radiation effects Humans Infrared radiation Infrared Rays - therapeutic use Internal Medicine Light therapy Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Nitric oxide Nitric Oxide - blood Original Article Peripheral Nervous System Diseases - therapy Phototherapy - methods
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Title	Pulsed infrared light therapy does not increase nitric oxide concentration in the blood of patients with type 1 and type 2 diabetes mellitus
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