Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome - Balemans, D.; Aguilera-Lizarraga, J.; Florens, M. V.; Jain, P.; Denadai-Souza, A.; Viola, M. F.; Alpizar, Y. A.; Van Der Merwe, S.; Vanden Berghe, P.; Talavera, K.; Vanner, S.; Wouters, M. M.; et al. (American journal of physiology: Gastrointestinal and liver physiology, 2019)
Keywords: Adult; Animal models; Animals; Ankyrins; Biopsy; Calcium (intracellular); Calcium imaging; Capsaicin receptors; Cinnamaldehyde; Data processing; Dorsal root ganglia; Female; Histamine; Histamine - metabolism; Humans; Intestine; Irritable bowel syndrome; Male; Mice, Transgenic; Middle Aged; Mucosa; Pain; Pain perception; Patients; Potentiation; Rectum; Sensory neurons; Sensory Receptor Cells - metabolism; Signal Transduction - physiology; Therapeutic applications; Transient Receptor Potential Channels - metabolism; Transient receptor potential proteins; TRPV Cation Channels - genetics; TRPV Cation Channels - metabolism; histamine 1 receptor; sensitization; TRP channels; visceral hypersensitivity