Lactobacillus brevis G101 Inhibits the Absorption of Monosodium Glutamate in Mice

• Published in: Journal of microbiology and biotechnology Vol. 24; no. 11; pp. 1592 - 1596
• Main Authors: Jang, Se-Eun, Han, Myung Joo, Kim, Se-Young, Kim, Dong-Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 28.11.2014
• Subjects: Animals; gamma-Aminobutyric Acid - blood; gamma-Aminobutyric Acid - metabolism; Intestinal Absorption - physiology; Lactobacillus brevis - physiology; Male; Mice; Mice, Inbred ICR; Sodium Glutamate - blood; Sodium Glutamate - pharmacokinetics; 생물학
• ISSN: 1017-7825; 1738-8872; 1738-8872
• DOI: 10.4014/jmb.1310.10125

To evaluate the effect of Lactobacillus brevis G-101 on absorption of monosodium glutamate (MSG), we orally administered MSG with or without G-101 in mice and measured the maximum concentration (Cmax) and blood concentration curve (AUC) of MSG and γ- aminobutyric acid (GABA). Oral administration of G-101 (1 × 10(9) CFU/mouse) potently inhibited Cmax and AUC of MSG by 97.8% and 94.3%, respectively (p < 0.05), but increased those of GABA by 32.1% and 67.7%, respectively (p < 0.05). G-101 inhibited the absorption of MSG. These results suggest that G-101 may reduce the side effect of MSG by inhibiting the absorption of MSG.