Learning directed acyclic graphs for ligands and receptors based on spatially resolved transcriptomic data of ovarian cancer - Chowdhury, Shrabanti; Ferri-Borgogno, Sammy; Yang, Peng; Wang, Wenyi; Peng, Jie; C Mok, Samuel; Wang, Pei (Briefings in bioinformatics, 2025)
Keywords: Biological activity; Case Study; Cell interactions; Communication; Computational Biology - methods; Datasets; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Graph theory; Humans; Immune response; Ligands; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Receptors; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Signal Transduction; Statistical methods; Stromal cells; Transcriptome; Transcriptomics; Tumor Microenvironment; Tumors; hill climbing; bootstrap aggregation; spatial transcriptomics data; prior domain knowledge; ligand–receptor network