Cerebral Oxygenation in Preterm Infants With Germinal Matrix–Intraventricular Hemorrhages

• Published in: Stroke (1970) Vol. 41; no. 12; pp. 2901 - 2907
• Main Authors: Verhagen, Elise A., ter Horst, Hendrik J., Keating, Paul, Martijn, Albert, Van Braeckel, Koenraad N.J.A., Bos, Arend F.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.2010
• Subjects: Apgar Score; Biological and medical sciences; Case-Control Studies; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - metabolism; Cerebral Infarction - metabolism; Cerebral Infarction - pathology; Cerebral Ventricles - diagnostic imaging; Cerebrovascular Circulation - physiology; Female; Fundamental and applied biological sciences. Psychology; Gestational Age; Hemodynamics - physiology; Humans; Infant, Newborn; Infant, Premature - metabolism; Longitudinal Studies; Male; Medical sciences; Neurology; Oxygen - blood; Oxygen Consumption - physiology; Spectroscopy, Near-Infrared; Ultrasonography; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; fractional tissue oxygen extraction; Stroke; Oxygen; Nervous system diseases; near-infrared spectroscopy; germinal matrix hemorrhages-intraventricular hemorrhages; preterm infants; Cardiovascular disease; Cerebral disorder; Encephalon; Vascular disease; Near infrared spectrometry; Prematurity; Central nervous system disease; Oxygenation; Cerebrovascular disease; Cerebral ventricle hemorrhage; cerebral oxygenation
• ISSN: 0039-2499; 1524-4628; 1524-4628
• DOI: 10.1161/STROKEAHA.110.597229

Background and Purpose— Preterm infants are at risk of developing germinal matrix hemorrhages–intraventricular hemorrhages (GMH-IVH). Disturbances in cerebral perfusion are associated with GMH-IVH. Regional cerebral tissue oxygen saturation (r c SO 2 ), measured with near-infrared spectroscopy, and fractional tissue oxygen extraction (FTOE) were calculated to obtain an indication of cerebral perfusion. Our objective was to determine whether r c SO 2 and FTOE were associated with GMH-IVH in preterm infants. Methods— This case–control study included 17 preterm infants with Grade I to III GMH-IVH or periventricular hemorrhagic infarction (median gestational age, 29.4 weeks; range, 25.4 to 31.9 weeks; birth weight, 1260 g; range, 850 to 1840 g). Seventeen preterm infants without GMH-IVH, matched for gestational age and birth weight, served as control subjects (gestational age, 29.9 weeks; range, 26.0 to 31.6 weeks; birth weight, 1310 g; range, 730 to 1975 g). R c SO 2 and transcutaneous arterial oxygen saturation were measured during 2 hours on Days 1 to 5, 8, and 15 after birth. FTOE was calculated as FTOE=(transcutaneous arterial oxygen saturation−r c SO 2 )/transcutaneous arterial oxygen saturation. Results— Multilevel analyses showed that r c SO 2 was lower and FTOE higher in infants with GMH-IVH on Days 1, 2, 3, 4, 5, 8, and 15. The largest difference occurred on Day 5 with r c SO 2 median 64% in infants with GMH-IVH versus 77% in control subjects and FTOE median 0.30 versus 0.17. R c SO 2 and FTOE were not affected by the grade of GMH-IVH. Conclusions— Preterm infants with GMH-IVH had lower r c SO 2 and higher FTOE during the first 2 weeks after birth irrespective of the grade of GMH-IVH. This suggests that cerebral perfusion is decreased persistently for 2 weeks in infants with GMH-IVH, even in the presence of mild hemorrhages.