Critical peripheral ischemia: Higher prevalence in Indian systemic lupus erythematosus inception cohort for research (INSPIRE)
Introduction There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE). Methods From the web-based database of INSPIRE, we extracted informa...
Saved in:
Published in | Lupus Vol. 33; no. 9; pp. 974 - 978 |
---|---|
Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.08.2024
Sage Publications Ltd |
Subjects | |
Online Access | Get full text |
ISSN | 0961-2033 1477-0962 1477-0962 |
DOI | 10.1177/09612033241263232 |
Cover
Abstract | Introduction
There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE).
Methods
From the web-based database of INSPIRE, we extracted information for patients with ‘Digital Infarct’ and ‘Digital gangrene’ at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date.
Results
Of 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls.
Conclusions
CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence. |
---|---|
AbstractList | Introduction
There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE).
Methods
From the web-based database of INSPIRE, we extracted information for patients with ‘Digital Infarct’ and ‘Digital gangrene’ at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date.
Results
Of 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls.
Conclusions
CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence. There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE). From the web-based database of INSPIRE, we extracted information for patients with 'Digital Infarct' and 'Digital gangrene' at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date. Of 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls. CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence. Introduction There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE). Methods From the web-based database of INSPIRE, we extracted information for patients with ‘Digital Infarct’ and ‘Digital gangrene’ at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date. Results Of 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls. Conclusions CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence. There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE).INTRODUCTIONThere is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts and gangrene from the Indian SLE inception cohort (INSPIRE).From the web-based database of INSPIRE, we extracted information for patients with 'Digital Infarct' and 'Digital gangrene' at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date.METHODSFrom the web-based database of INSPIRE, we extracted information for patients with 'Digital Infarct' and 'Digital gangrene' at enrolment into cohort, together considered as critical peripheral ischemia (CPI); all others were controls. We describe the associations of CPI with SLE clinical phenotype, autoantibodies, and disease activity at enrolment. We also report short term outcomes viz. Digital tissue loss and early mortality up to 6 months and recurrence of digital ischemic events in cases till date.Of 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls.RESULTSOf 2503 SLE patients enrolled into the INSPIRE cohort, we identified 75 (2.9%) patients with CPI, 72 (96%) women and 6 (8%) children. Of them, 55 (73.3%) had digital gangrene and 21 (28%) patients had digital infarcts. Majority of digital gangrene resulted in amputation distal to terminal phalanx (63.6%). Multivariable analysis showed that pulmonary hypertension AOR [6.34 (1.99, 20.2)], coexistent thrombosis AOR [27.8 (15.7, 48.7)], triple antiphospholipid antibody positivity AOR [5.36 (1.67, 16.9)] and the presence of anti-Scl-70-antibody AOR [5.59 (1.86, 16.7)] were more likely while patients with class 3 or 4 lupus nephritis AOR [0.37 (0.15, 0.95)] and anti-nucleosome antibodies AOR [0.47 (0.23, 0.99)] were less likely to be associated with CPI. SLEDAI and short-term mortality were similar between cases and controls.CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence.CONCLUSIONSCPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports. Both prothrombotic state and vasculopathy contribute to its occurrence. |
Author | Ghosh, Parasar Rathi, Manish Shobha, Vineeta Gupta, Ranjan Tripathy, Saumya Ranjan Selvam, Sumitra Jain, Avinash Rajasekhar, Liza Aggarwal, Amita V, Nayana Mathew, Ashish J Manuel, Sandra Kavadichanda, Chengappa |
Author_xml | – sequence: 1 givenname: Vineeta orcidid: 0000-0001-5271-0766 surname: Shobha fullname: Shobha, Vineeta organization: Department of Clinical Immunology and Rheumatology – sequence: 2 givenname: Liza orcidid: 0000-0002-9789-9985 surname: Rajasekhar fullname: Rajasekhar, Liza organization: Department of Clinical Immunology and Rheumatology – sequence: 3 givenname: Sandra surname: Manuel fullname: Manuel, Sandra organization: Department of Clinical Immunology and Rheumatology – sequence: 4 givenname: Nayana surname: V fullname: V, Nayana organization: Department of Clinical Immunology and Rheumatology – sequence: 5 givenname: Ranjan orcidid: 0000-0003-3965-5410 surname: Gupta fullname: Gupta, Ranjan organization: Department of Clinical Immunology and Rheumatology – sequence: 6 givenname: Saumya Ranjan surname: Tripathy fullname: Tripathy, Saumya Ranjan organization: Department of Clinical Immunology and Rheumatology – sequence: 7 givenname: Parasar surname: Ghosh fullname: Ghosh, Parasar organization: Department of Clinical Immunology and Rheumatology – sequence: 8 givenname: Chengappa orcidid: 0000-0002-3643-3989 surname: Kavadichanda fullname: Kavadichanda, Chengappa organization: Department of Clinical Immunology and Rheumatology – sequence: 9 givenname: Ashish J surname: Mathew fullname: Mathew, Ashish J organization: Department of Clinical Immunology and Rheumatology – sequence: 10 givenname: Manish orcidid: 0000-0002-2642-8895 surname: Rathi fullname: Rathi, Manish organization: Department of Clinical Immunology and Rheumatology – sequence: 11 givenname: Avinash surname: Jain fullname: Jain, Avinash organization: Department of Clinical Immunology and Rheumatology – sequence: 12 givenname: Sumitra surname: Selvam fullname: Selvam, Sumitra organization: Department of Clinical Immunology and Rheumatology – sequence: 13 givenname: Amita orcidid: 0000-0002-2187-5186 surname: Aggarwal fullname: Aggarwal, Amita organization: Department of Clinical Immunology and Rheumatology |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38922692$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kUtrGzEQgEVJaZy0P6CXIuglPWyix1pa9RZM0hhCU_o4L2PtbKywlraStuBLf3tknBBIaE-SZr5vGM0ckQMfPBLynrNTzrU-Y0ZxwaQUNRdKCilekRmvta5KQhyQ2S5f7YBDcpTSHWNMcqPekEPZGCGUETPydxFddhYGOmJ04xpjubpk17hx8JleudsSomPEPzCgt0idp0vfOfA0bVMulKXDNE6JYtzmYkEOqbxcYcfsgqc2rEPMtA-RRkwI0a7pyfLrj2_L7xef3pLXPQwJ3z2cx-TX5cXPxVV1ffNluTi_rqxUTa5qaVe9aBrV9QAcBWizEsCY0sgVBwW1nPdzoVWDWDccpOH9SnTzDo00jHXymJzs644x_J4w5XZTPonDAB7DlFrJtNCmUbUq6Mdn6F2Yoi_dFarRUiulRaE-PFDTaoNdO0a3gbhtHydbAL0HbAwpRexb6zLsJpIjuKHlrN3tsH2xw2LyZ-Zj8f85p3snwS0-Nfxv4R6cT6nu |
CitedBy_id | crossref_primary_10_1093_mrcr_rxaf006 |
Cites_doi | 10.1046/j.1468-3083.2000.00120.x 10.1001/jama.1962.03050310006002 10.1177/09612033231177788 10.1093/rheumatology/ken210 10.1177/0961203309106643 10.1016/j.avsg.2016.05.087 10.2340/00015555-0658 10.2169/internalmedicine.50.4617 10.1016/j.rbr.2017.05.008 10.1093/rheumatology/ken451 10.1002/art.34473 10.1007/s00296-020-04766-3 |
ContentType | Journal Article |
Copyright | The Author(s) 2024 |
Copyright_xml | – notice: The Author(s) 2024 |
DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
DOI | 10.1177/09612033241263232 |
DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1477-0962 |
EndPage | 978 |
ExternalDocumentID | 38922692 10_1177_09612033241263232 10.1177_09612033241263232 |
Genre | Journal Article |
GeographicLocations | India |
GeographicLocations_xml | – name: India |
GrantInformation_xml | – fundername: Department of Biotechnology, Ministry of Science and Technology, India grantid: [BT/PR23111/MED/30/1852/2017] funderid: https://doi.org/10.13039/501100001407 |
GroupedDBID | --- -TM .2E .2F .2G .2J .2N .GJ 01A 0R~ 18M 1~K 29L 31R 31S 31U 31X 31Y 31Z 36B 39C 4.4 53G 54M 5GY 5VS 7X7 88E 8FI 8FJ 8R4 8R5 AABMB AABOD AACKU AACMV AACTG AADUE AAEWN AAGGD AAGLT AAGMC AAJIQ AAJOX AAJPV AAKGS AANSI AAPEO AAQDB AAQXH AAQXI AARDL AARIX AATAA AATBZ AAUAS AAXOT AAYTG AAZBJ ABAFQ ABAWP ABCCA ABCJG ABDBF ABDWY ABEIX ABFWQ ABHKI ABHQH ABIDT ABJIS ABJZC ABKRH ABLUO ABOCM ABPGX ABPNF ABQKF ABQXT ABRHV ABUJY ABUWG ABVFX ABVVC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGZU ACJER ACJTF ACLFY ACLHI ACLZU ACOFE ACOXC ACPRK ACROE ACRPL ACSIQ ACUAV ACUHS ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADEIA ADMPF ADNBR ADNMO ADNON ADRRZ ADSTG ADTBJ ADUCT ADUKL ADVBO ADYCS ADZZY AECGH AECVZ AEDTQ AEGXH AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRA AFKRG AFMOU AFOSN AFQAA AFUIA AFWMB AGHKR AGKLV AGNHF AGPXR AGQPQ AGWFA AGWNL AHDMH AHMBA AIAGR AIGRN AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ ALIPV ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV ASPBG AUTPY AUVAJ AVWKF AYAKG AZFZN AZQEC B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BENPR BKIIM BKNYI BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD BYIEH C45 CBRKF CCPQU CDWPY CFDXU CORYS CQQTX CS3 CUTAK DB0 DC- DC0 DD- DD0 DE- DF0 DO- DOPDO DU5 DV7 DV9 D~Y EAD EAP EBC EBD EBS EJD EMB EMK EMOBN EPL ESX F5P FEDTE FHBDP FYUFA GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION H13 HF~ HMCUK HVGLF HZ~ J8X K.F K.J K9- M0R M1P N9A O9- OVD P.B P2P PHGZM PHGZT PQQKQ PROAC PSQYO Q1R Q2X Q7K Q7L Q7R Q7U Q7X Q82 Q83 ROL S01 SASJQ SAUOL SCNPE SDB SFB SFC SFK SFN SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPQ SPV SQCSI STM SV3 TEORI TUS UKHRP ZONMY ZPPRI ZRKOI ZSSAH 0SE AAEJI AAPII AAYXX AJGYC AJHME AJVBE CITATION PJZUB PPXIY PUEGO CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
ID | FETCH-LOGICAL-c368t-43cbf2886dfaa1e2a79b2a0067e161a6a435f52768ee481a391fb2d5de93900d3 |
ISSN | 0961-2033 1477-0962 |
IngestDate | Sat Sep 27 21:27:16 EDT 2025 Sat Jul 26 02:51:06 EDT 2025 Mon Jul 21 06:04:23 EDT 2025 Thu Apr 24 22:56:31 EDT 2025 Wed Oct 01 06:53:08 EDT 2025 Tue Jun 17 22:27:19 EDT 2025 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | Systemic lupus erythematosus thrombosis Indian systemic lupus erythematosus inception cohort for research critical peripheral ischemia vasculopathy |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c368t-43cbf2886dfaa1e2a79b2a0067e161a6a435f52768ee481a391fb2d5de93900d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ORCID | 0000-0002-9789-9985 0000-0003-3965-5410 0000-0001-5271-0766 0000-0002-2187-5186 0000-0002-3643-3989 0000-0002-2642-8895 |
PMID | 38922692 |
PQID | 3087376672 |
PQPubID | 32637 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_3072798646 proquest_journals_3087376672 pubmed_primary_38922692 crossref_citationtrail_10_1177_09612033241263232 crossref_primary_10_1177_09612033241263232 sage_journals_10_1177_09612033241263232 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 20240800 2024-08-00 2024-Aug 20240801 |
PublicationDateYYYYMMDD | 2024-08-01 |
PublicationDate_xml | – month: 8 year: 2024 text: 20240800 |
PublicationDecade | 2020 |
PublicationPlace | London, England |
PublicationPlace_xml | – name: London, England – name: England – name: London |
PublicationTitle | Lupus |
PublicationTitleAlternate | Lupus |
PublicationYear | 2024 |
Publisher | SAGE Publications Sage Publications Ltd |
Publisher_xml | – name: SAGE Publications – name: Sage Publications Ltd |
References | Rosato, Molinaro, Pisarri 2011; 50 Sakamoto, Silva, da Silva 2017; 57 Petri, Orbai, Alarcón 2012; 64 Dubois, Arterberry 1962; 181 Küçükşahin, Düzgün, Okoh 2014; 2014 Steunenberg, Raats, Te Slaa 2016; 36 Liu, Zhang, Tian 2009; 18 Rajasekhar, Jayachandran, Prabu 2009; 48 Shobha, Aggarwal, Rajasekhar 2021; 41 Jeffery, Narshi, Isenberg 2008; 47 Nagai, Shimizu, Suto 2009; 89 Vocks, Welcker, Ring 2000; 14 Alalawi, Alkenany, Almahroos 2020; 12 Rua, Isenberg 2023; 32 Ha-Ou-Nou, Zahlane, Benjilali 2017; 42 bibr6-09612033241263232 bibr9-09612033241263232 bibr2-09612033241263232 bibr15-09612033241263232 Küçükşahin O (bibr14-09612033241263232) 2014; 2014 bibr7-09612033241263232 bibr1-09612033241263232 bibr4-09612033241263232 Alalawi ZM (bibr12-09612033241263232) 2020; 12 bibr8-09612033241263232 bibr5-09612033241263232 bibr3-09612033241263232 bibr13-09612033241263232 bibr10-09612033241263232 Ha-Ou-Nou FZ (bibr11-09612033241263232) 2017; 42 |
References_xml | – volume: 181 start-page: 366 year: 1962 article-title: Gangrene as a manifestation of systemic lupus erythematosus publication-title: JAMA – volume: 47 start-page: 1379 issue: 9 year: 2008 article-title: Prevalence, serological features, response to treatment and outcome of critical peripheral ischaemia in a cohort of lupus patients publication-title: Rheumatology – volume: 12 start-page: e6667 issue: 1 year: 2020 article-title: Peripheral gangrene as the initial presentation of systemic lupus erythematosus in emergency department publication-title: Cureus – volume: 14 start-page: 419 issue: 5 year: 2000 article-title: Digital gangrene: a rare skin symptom in systemic lupus erythematosus publication-title: J Eur Acad Dermatol Venereol – volume: 50 start-page: 767 issue: 7 year: 2011 article-title: Digital ulcers as an initial manifestation of systemic lupus erythematosus publication-title: Intern Med – volume: 32 start-page: 880 issue: 7 year: 2023 article-title: A review of the development of gangrene in patients with systemic lupus erythematosus - a 44-year follow-up study publication-title: Lupus – volume: 42 start-page: 50 issue: 1 year: 2017 article-title: [Extensive digital gangrene revealing late-onset systemic lupus erythematosus] publication-title: J Med Vasc – volume: 48 start-page: 451 issue: 4 year: 2009 article-title: Comment on: prevalence, serological features, response to treatment and outcome of critical peripheral ischaemia in a cohort of lupus patients publication-title: Rheumatology – volume: 41 start-page: 887 issue: 5 year: 2021 article-title: Indian SLE Inception cohort for Research (INSPIRE): the design of a multi-institutional cohort publication-title: Rheumatol Int – volume: 89 start-page: 398 issue: 4 year: 2009 end-page: 401 article-title: Digital gangrene in systemic lupus erythematosus publication-title: Acta Derm Venereol – volume: 2014 start-page: 763608 year: 2014 article-title: Response to rituximab in a case of lupus associated digital ischemia publication-title: Case Rep Rheumatol – volume: 57 start-page: 583 issue: 6 year: 2017 end-page: 589 article-title: Initial digital vasculitis in a large multicenter cohort of childhood-onset systemic lupus erythematosus publication-title: Rev Bras Reumatol Engl Ed – volume: 18 start-page: 1112 issue: 12 year: 2009 article-title: Prevalence, risk factors and outcome of digital gangrene in 2684 lupus patients publication-title: Lupus – volume: 36 start-page: 310 year: 2016 article-title: Quality of life in patients suffering from critical limb ischemia publication-title: Ann Vasc Surg – volume: 64 start-page: 2677 issue: 8 year: 2012 article-title: Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus publication-title: Arthritis Rheum – ident: bibr10-09612033241263232 doi: 10.1046/j.1468-3083.2000.00120.x – ident: bibr1-09612033241263232 doi: 10.1001/jama.1962.03050310006002 – ident: bibr2-09612033241263232 doi: 10.1177/09612033231177788 – ident: bibr3-09612033241263232 doi: 10.1093/rheumatology/ken210 – volume: 2014 start-page: 763608 year: 2014 ident: bibr14-09612033241263232 publication-title: Case Rep Rheumatol – ident: bibr5-09612033241263232 doi: 10.1177/0961203309106643 – volume: 42 start-page: 50 issue: 1 year: 2017 ident: bibr11-09612033241263232 publication-title: J Med Vasc – ident: bibr6-09612033241263232 doi: 10.1016/j.avsg.2016.05.087 – ident: bibr9-09612033241263232 doi: 10.2340/00015555-0658 – ident: bibr13-09612033241263232 doi: 10.2169/internalmedicine.50.4617 – volume: 12 start-page: e6667 issue: 1 year: 2020 ident: bibr12-09612033241263232 publication-title: Cureus – ident: bibr15-09612033241263232 doi: 10.1016/j.rbr.2017.05.008 – ident: bibr4-09612033241263232 doi: 10.1093/rheumatology/ken451 – ident: bibr8-09612033241263232 doi: 10.1002/art.34473 – ident: bibr7-09612033241263232 doi: 10.1007/s00296-020-04766-3 |
SSID | ssj0003196 |
Score | 2.4272306 |
Snippet | Introduction
There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of... There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of digital infarcts... Introduction There is limited literature on digital ischemia in systemic Lupus erythematosus (SLE). We report the prevalence, associations and outcome of... |
SourceID | proquest pubmed crossref sage |
SourceType | Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 974 |
SubjectTerms | Adolescent Adult Amputation Amputation, Surgical - statistics & numerical data Antiphospholipid antibodies Autoantibodies Child Cohort Studies Female Fingers - blood supply Fingers - pathology Gangrene Gangrene - epidemiology Gangrene - etiology Humans India - epidemiology Ischemia Ischemia - epidemiology Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - epidemiology Lupus nephritis Male Middle Aged Mortality Multivariate Analysis Phenotypes Prevalence Risk Factors Systemic lupus erythematosus Thrombosis Vascular diseases Young Adult |
Title | Critical peripheral ischemia: Higher prevalence in Indian systemic lupus erythematosus inception cohort for research (INSPIRE) |
URI | https://journals.sagepub.com/doi/full/10.1177/09612033241263232 https://www.ncbi.nlm.nih.gov/pubmed/38922692 https://www.proquest.com/docview/3087376672 https://www.proquest.com/docview/3072798646 |
Volume | 33 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1477-0962 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0003196 issn: 0961-2033 databaseCode: ABDBF dateStart: 20060501 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdKJyFeEN90DGQkxFeUqUncJOZtg1YDtQVt7dS3yElcNdClJU0etgf-Hv5Mzh9x2w0m4CWq7CROc7-c787n3yH0gqVBOmV8ajPQizZJktSmPCC2A44b82F-CYjYOzwY-kdj8mnSmTQaPzeylqoy3k8ufruv5H-kCm0gV7FL9h8ka24KDfAb5AtHkDAc_0rGpk6BoCuW_ABzKwN3lZ9lsuSOTuJYFoLTW37CmYgBSjYCReGcJda8WlYrixfnir91sapEipbOdrFEAd2ilMmImhdoJo3S4cmXj8fdOo5Qb6gWtzIxm9kinjHrVNAdlkb5H7OvMG9-m7HC6mcXpnnA8krlC5ywPC1M-5CdM7Vr7XQzPuESkx2n45MbqUcqt2-driTDkL4DMlVkGPtcKWESBDZ0bGlpfYZCI91QuVRV-dGzN1UFga5ODHJpWowmBgOzRfDU68jqFgn38HPUG_f70ag7Gb1cfrdFfTKxjq-LtdxAO27g-24T7RwcfjjsmVlfqDLJ66j_j15Bl-Rel0fdtoGuODZbSYXSzhndQbe1g4IPFNruogbP76GbA52CcR_9qEGH16DDNejeYQU5vIYcznKsIIdryGEJObwFOWwghxXkMEAO15DDrzXg3jxA41539P7I1kU87MTzw9ImXhJP3TD0QSUwh7ssoLHLhJHEwdlgPgN7fdqBdxpyTkKHedSZxm7aSTn1aLudeg9RM1_k_DHCKaEOC7mfuLFLOkmHOjENuUdCTgmDiamF2vVrjRLNcC8Krcwjpya1vyyJFnprLlkqepfrTt6rZRVpLbCKBKMmTNJ-AN3PTTfoaLHwxnK-qMQ54CWIOgh-Cz1SMjajgcMAHhCFq18Joa9v_MfH2L3-MZ6gW-vPcA81y6LiT8FwLuNnGrO_ABQuwPU |
linkProvider | EBSCOhost |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Critical+peripheral+ischemia%3A+Higher+prevalence+in+Indian+systemic+lupus+erythematosus+inception+cohort+for+research+%28INSPIRE%29&rft.jtitle=Lupus&rft.au=Shobha+Vineeta&rft.au=Rajasekhar+Liza&rft.au=Manuel%2C+Sandra&rft.au=Nayana%2C+V&rft.date=2024-08-01&rft.pub=Sage+Publications+Ltd&rft.issn=0961-2033&rft.eissn=1477-0962&rft.volume=33&rft.issue=9&rft.spage=974&rft.epage=978&rft_id=info:doi/10.1177%2F09612033241263232&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0961-2033&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0961-2033&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0961-2033&client=summon |