Assessment of Chronic Hepatitis and Fibrosis: Comparison of MR Elastography and Diffusion-Weighted Imaging

• Published in: American journal of roentgenology (1976) Vol. 196; no. 3; pp. 553 - 561
• Main Authors: Wang, Yi, Ganger, Daniel R., Levitsky, Josh, Sternick, Laura A., McCarthy, Robert J., Chen, Zongming E., Fasanati, Charles W., Bolster, Bradley, Shah, Saurabh, Zuehlsdorff, Sven, Omary, Reed A., Ehman, Richard L., Miller, Frank H.
• Format: Journal Article
• Language: English
• Published: Reston, VA American Roentgen Ray Society 01.03.2011
• Subjects: Adult; Aged; Biological and medical sciences; Cirrhosis; Classification; Contrast Media; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Elasticity Imaging Techniques - methods; Female; Fibrosis; Gadolinium DTPA; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis; Hepatitis, Chronic - diagnosis; Hepatitis, Chronic - pathology; Humans; Liver Cirrhosis - diagnosis; Liver Cirrhosis - pathology; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Predictive Value of Tests; Prospective Studies; ROC Curve; Sensitivity and Specificity; Statistics, Nonparametric; Digestive system; Liver; Hepatic disease; Nuclear magnetic resonance imaging; Hepatitis; Chronic; Magnetic resonance elastography; chronic hepatitis; diffusion-weighted imaging (DWI); Fibrosis; Medical imagery; Digestive diseases; MR elastography (MRE); Comparative study
• ISSN: 0361-803X; 1546-3141; 1546-3141
• DOI: 10.2214/AJR.10.4580

The purpose of our study was to compare the utility of MR elastography (MRE) and diffusion-weighted imaging (DWI) in characterizing fibrosis and chronic hepatitis in patients with chronic liver diseases. Seventy-six patients with chronic liver disease underwent abdominal MRI, MRE, and DWI. Severities of liver fibrosis and chronic hepatitis were graded by histopathologic analysis according to standard disease-specific classifications. The overall predictive ability of MRE and DWI in assessment of fibrosis was compared by constructing a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC) on the basis of histopathologic analysis. Using ROC analysis, MRE showed greater capability than DWI in discriminating stage 2 or greater (≥ F2), stage 3 or greater (≥ F3), and cirrhosis (≥ F4), shown as significant differences in AUC (p = 0.003, p = 0.001, and p = 0.001, respectively). Higher sensitivity and specificity were shown by MRE in predicting fibrosis scores ≥ F2 (91% and 97%), scores ≥ F3 (92% and 95%), and scores F4 (95% and 87%) compared with DWI (84% and 82%, 88% and 76%, and 85% and 68%, respectively). Although MRE had higher ability in identification of liver with fibrosis scores ≥ F1 than DWI, a significant difference was not seen (p = 0.398). Stiffness values on MRE increased in relation to increasing severity of fibrosis confirmed by histopathology scores; however, a consistent relationship between apparent diffusion coefficient (ADC) values and stage of fibrosis was not shown. In addition, liver tissue with chronic hepatitis preceding fibrosis may account for mild elevation of liver stiffness. MRE had greater predictive ability in distinguishing the stages of liver fibrosis than DWI.