Treadmill exercise alleviates short-term memory impairment in 6- hydroxydopamine-induced Parkinson’s rats

Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell prolifera...

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Bibliographic Details
Published inJournal of exercise rehabilitation Vol. 9; no. 3; pp. 354 - 361
Main Authors Cho, Han-Sam, Shin, Mal-Soon, Song, Wook, Jun, Tae-Won, Lim, Baek-Vin, Kim, Young-Pyo, Kim, Chang-Ju
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Exercise Rehabilitation 30.06.2013
한국운동재활학회
Subjects
Original
심리과학
Treadmill exercise
Cell proliferation
Parkinson’s rats
6-Hydroxydopamine
Apoptosis
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ISSN2288-176X
2288-1778
2288-1778
DOI10.12965/jer.130048

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Table of Contents:
  • Abstract INTRODUCTION MATERIALS AND METHODS Animals and treatments Apomorphine-induced rotation test Exercise protocol Step-down avoidance task Tissue preparation TH immunohistochemistry Caspase-3 immunohistochemistry BrdU immunohistochemistry Data analysis RESULTS Effect of 6-OHDA treatment on apomorphine-induced rotation test Effect of treadmill exercise on latency in the step-down avoidance task after 6-OHDA-injection Effect of treadmill exercise on TH expression in the nigrostriatum after 6-OHDA injection Effect of treadmill exercise on caspase-3 expression in the substantia nigra after 6-OHDA injection Effect of treadmill exercise on cell proliferation in the dentate gyrus after 6-OHDA injection DISCUSSION CONFLICT OF INTEREST REFERENCES