Treadmill exercise alleviates short-term memory impairment in 6- hydroxydopamine-induced Parkinson’s rats
Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell prolifera...
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| Published in | Journal of exercise rehabilitation Vol. 9; no. 3; pp. 354 - 361 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society of Exercise Rehabilitation
30.06.2013
한국운동재활학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2288-176X 2288-1778 2288-1778 |
| DOI | 10.12965/jer.130048 |
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| Abstract | Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. Parkinson’s rats were made by injection of 6- hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6- OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill run-ning for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alle-viated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. The present re-sults show that treadmill exercise may provide therapeutic value for the Parkinson’s disease. |
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| AbstractList | Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson's disease. In the present study, we investigated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. Parkinson's rats were made by injection of 6-hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6-OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill running for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alleviated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. The present results show that treadmill exercise may provide therapeutic value for the Parkinson's disease. Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investigated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. Parkinson’s rats were made by injection of 6-hydroxydopamine (6-OHDA)into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6-OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in shortterm memory impairment. However, the rats performing treadmill running for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alleviated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. The present results show that treadmill exercise may provide therapeutic value for the Parkinson’s disease. KCI Citation Count: 18 Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. Parkinson’s rats were made by injection of 6- hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6- OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill run-ning for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alle-viated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. The present re-sults show that treadmill exercise may provide therapeutic value for the Parkinson’s disease. Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson's disease. In the present study, we investigated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. Parkinson's rats were made by injection of 6-hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6-OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill running for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alleviated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. The present results show that treadmill exercise may provide therapeutic value for the Parkinson's disease.Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson's disease. In the present study, we investigated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. Parkinson's rats were made by injection of 6-hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6-OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill running for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alleviated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson's rats. The present results show that treadmill exercise may provide therapeutic value for the Parkinson's disease. |
| Author | Kim, Chang-Ju Jun, Tae-Won Lim, Baek-Vin Kim, Young-Pyo Cho, Han-Sam Shin, Mal-Soon Song, Wook |
| AuthorAffiliation | 1 Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea 4 Faculty of Exercise and Sports Sciences, College of Natural Sciences, Jeju National University, Jeju, Korea 2 Department of Physical Education, College of Education, Seoul National University, Seoul, Korea 3 Department of Exercise Prescription, Division of Leisure & Sports Science, Dongseo University, Busan, Korea |
| AuthorAffiliation_xml | – name: 2 Department of Physical Education, College of Education, Seoul National University, Seoul, Korea – name: 1 Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea – name: 4 Faculty of Exercise and Sports Sciences, College of Natural Sciences, Jeju National University, Jeju, Korea – name: 3 Department of Exercise Prescription, Division of Leisure & Sports Science, Dongseo University, Busan, Korea |
| Author_xml | – sequence: 1 givenname: Han-Sam surname: Cho fullname: Cho, Han-Sam – sequence: 2 givenname: Mal-Soon surname: Shin fullname: Shin, Mal-Soon – sequence: 3 givenname: Wook surname: Song fullname: Song, Wook – sequence: 4 givenname: Tae-Won surname: Jun fullname: Jun, Tae-Won – sequence: 5 givenname: Baek-Vin surname: Lim fullname: Lim, Baek-Vin – sequence: 6 givenname: Young-Pyo surname: Kim fullname: Kim, Young-Pyo – sequence: 7 givenname: Chang-Ju surname: Kim fullname: Kim, Chang-Ju |
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| Cites_doi | 10.1002/mds.10444 10.1097/00019052-200312002-00003 10.1016/S0306-4522(03)00096-4 10.1093/toxsci/kfi241 10.1002/bies.1089 10.1053/apmr.2000.4439 10.1073/pnas.040556597 10.1038/nn1265 10.12965/jer.130006 10.1016/S0278-5846(03)00019-8 10.1016/j.lfs.2012.10.003 10.1016/j.neulet.2007.06.031 10.1016/S0024-3205(03)00655-6 10.1016/j.molbrainres.2004.08.008 10.1073/pnas.96.23.13427 10.1046/j.1460-9568.2000.00130.x 10.1016/S0006-8993(99)02459-2 10.1016/S0969-9961(03)00030-5 10.1046/j.1471-4159.2003.01657.x 10.1016/S0197-4580(03)00112-X 10.1016/S0014-4886(03)00028-1 10.1016/j.neulet.2003.11.005 10.1080/19768354.2011.640352 10.1097/00001756-199805110-00048 10.1111/j.1749-6632.2003.tb07458.x 10.1212/01.WNL.0000151960.28687.93 10.1038/3305 10.1016/S0301-0082(01)00003-X |
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| References | ref13 ref12 ref15 ref14 ref31 ref11 ref10 ref32 ref2 ref1 ref16 Schalow (ref25) 2005 ref19 ref18 Schapira (ref26) 2001 Trejo (ref30) 2001 ref24 Jellinger (ref17) 1995 ref23 ref20 ref22 ref21 ref28 ref27 ref29 ref8 ref7 ref9 ref4 ref3 ref6 ref5 24278900 - J Exerc Rehabil. 2013 Aug 31;9(4):447 |
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| Snippet | Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects... Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson's disease. In the present study, we investigated the effects of... Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investigated the effects of... |
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| TableOfContents | Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Apomorphine-induced rotation test
Exercise protocol
Step-down avoidance task
Tissue preparation
TH immunohistochemistry
Caspase-3 immunohistochemistry
BrdU immunohistochemistry
Data analysis
RESULTS
Effect of 6-OHDA treatment on apomorphine-induced rotation test
Effect of treadmill exercise on latency in the step-down avoidance task after 6-OHDA-injection
Effect of treadmill exercise on TH expression in the nigrostriatum after 6-OHDA injection
Effect of treadmill exercise on caspase-3 expression in the substantia nigra after 6-OHDA injection
Effect of treadmill exercise on cell proliferation in the dentate gyrus after 6-OHDA injection
DISCUSSION
CONFLICT OF INTEREST
REFERENCES |
| Title | Treadmill exercise alleviates short-term memory impairment in 6- hydroxydopamine-induced Parkinson’s rats |
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