Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females
Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction, because mitochondria in vascular endothelial cells are the major site of superoxide production. In the present study, we surveyed mitochondri...
Saved in:
| Published in | Mitochondrion Vol. 7; no. 1-2; pp. 72 - 79 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
01.02.2007
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1567-7249 |
| DOI | 10.1016/j.mito.2006.11.002 |
Cover
| Abstract | Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction, because mitochondria in vascular endothelial cells are the major site of superoxide production. In the present study, we surveyed mitochondrial haplogroups associated with atherothrombotic cerebral infarction in 1081 Japanese subjects. Twenty-six mitochondrial single nucleotide polymorphisms of 11 major mitochondrial haplogroups (F, B, A, N9a, M7a, M7b, M7c, G1, G2, D4, and D5) were determined by use of 28-plex PCR and fluorescent beads combined with sequence-specific oligonucleotide probes. Multivariate logistic regression analysis with adjustment for conventional risk factors revealed that mitochondrial haplogroup A was associated with atherothrombotic cerebral infarction in female subjects (P< 0.05). However, no significant association was detected for males. Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels. |
|---|---|
| AbstractList | Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction, because mitochondria in vascular endothelial cells are the major site of superoxide production. In the present study, we surveyed mitochondrial haplogroups associated with atherothrombotic cerebral infarction in 1081 Japanese subjects. Twenty-six mitochondrial single nucleotide polymorphisms of 11 major mitochondrial haplogroups (F, B, A, N9a, M7a, M7b, M7c, G1, G2, D4, and D5) were determined by use of 28-plex PCR and fluorescent beads combined with sequence-specific oligonucleotide probes. Multivariate logistic regression analysis with adjustment for conventional risk factors revealed that mitochondrial haplogroup A was associated with atherothrombotic cerebral infarction in female subjects (P< 0.05). However, no significant association was detected for males. Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels. Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction, because mitochondria in vascular endothelial cells are the major site of superoxide production. In the present study, we surveyed mitochondrial haplogroups associated with atherothrombotic cerebral infarction in 1081 Japanese subjects. Twenty-six mitochondrial single nucleotide polymorphisms of 11 major mitochondrial haplogroups (F, B, A, N9a, M7a, M7b, M7c, G1, G2, D4, and D5) were determined by use of 28-plex PCR and fluorescent beads combined with sequence-specific oligonucleotide probes. Multivariate logistic regression analysis with adjustment for conventional risk factors revealed that mitochondrial haplogroup A was associated with atherothrombotic cerebral infarction in female subjects (P< 0.05). However, no significant association was detected for males. Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels.Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction, because mitochondria in vascular endothelial cells are the major site of superoxide production. In the present study, we surveyed mitochondrial haplogroups associated with atherothrombotic cerebral infarction in 1081 Japanese subjects. Twenty-six mitochondrial single nucleotide polymorphisms of 11 major mitochondrial haplogroups (F, B, A, N9a, M7a, M7b, M7c, G1, G2, D4, and D5) were determined by use of 28-plex PCR and fluorescent beads combined with sequence-specific oligonucleotide probes. Multivariate logistic regression analysis with adjustment for conventional risk factors revealed that mitochondrial haplogroup A was associated with atherothrombotic cerebral infarction in female subjects (P< 0.05). However, no significant association was detected for males. Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels. |
| Author | Nishigaki, Yutaka Kato, Kimihiko Segawa, Tomonori Yamada, Yoshiji Yokoi, Kiyoshi Matsuo, Hitoshi Tanaka, Masashi Yamaguchi, Sachiyo Nozawa, Yoshinori Fuku, Noriyuki Watanabe, Sachiro |
| Author_xml | – sequence: 1 givenname: Yutaka surname: Nishigaki fullname: Nishigaki, Yutaka – sequence: 2 givenname: Yoshiji surname: Yamada fullname: Yamada, Yoshiji – sequence: 3 givenname: Noriyuki surname: Fuku fullname: Fuku, Noriyuki – sequence: 4 givenname: Hitoshi surname: Matsuo fullname: Matsuo, Hitoshi – sequence: 5 givenname: Tomonori surname: Segawa fullname: Segawa, Tomonori – sequence: 6 givenname: Sachiro surname: Watanabe fullname: Watanabe, Sachiro – sequence: 7 givenname: Kimihiko surname: Kato fullname: Kato, Kimihiko – sequence: 8 givenname: Kiyoshi surname: Yokoi fullname: Yokoi, Kiyoshi – sequence: 9 givenname: Sachiyo surname: Yamaguchi fullname: Yamaguchi, Sachiyo – sequence: 10 givenname: Yoshinori surname: Nozawa fullname: Nozawa, Yoshinori – sequence: 11 givenname: Masashi surname: Tanaka fullname: Tanaka, Masashi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17257906$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kD1P5DAQhl2A-P4DFMgV3ebGdmInJUJwxwl0DdSW1xmzXpI42N6Cf3-OACFRUIxmiud9NXqOyd4UJiTknEHFgMlf22r0OVQcQFaMVQB8jxyxRqqV4nV3SI5T2gIwxTg_IIdM8UZ1II_I_FBidhOmPnoz0I2Zh_Acw26mV9QnaugzTpi9pdGnF-qMzSFSV8bkDcaQNzGM67AAFiOuY-nwkzPRZh-mctK_ZjYTJqQORzNgOiX7zgwJzz72CXm6vXm8_rO6__f77vrqfmWFVHllu9py1QnBhOn73nSAKFjd9ogSuJBcNs4JwFbJtgbW9Uw5NJ3jrqktMC5OyOV77xzD6w5T1qNPFoehfBN2SSvgjWigLeDFB7hbj9jrOfrRxDf96agA_B2wMaQU0X0hoBf5eqsX-XqRrxnTRX4Jtd9C1mezSMnR-OGn6H9q2o7P |
| CitedBy_id | crossref_primary_10_31857_S0016675823070068 crossref_primary_10_1007_s12031_020_01778_3 crossref_primary_10_1155_2012_824275 crossref_primary_10_1038_nrneurol_2011_80 crossref_primary_10_1186_1756_0500_7_223 crossref_primary_10_1002_jnr_24274 crossref_primary_10_1007_s00439_006_0269_z crossref_primary_10_1371_journal_pgen_1003696 crossref_primary_10_5551_jat_6742 crossref_primary_10_1371_journal_pone_0049684 crossref_primary_10_3389_fmolb_2019_00128 crossref_primary_10_3389_fphys_2024_1395371 crossref_primary_10_1016_j_mito_2017_12_004 crossref_primary_10_1016_j_mito_2008_04_002 crossref_primary_10_3390_cells9081885 crossref_primary_10_1007_s00415_009_5305_1 crossref_primary_10_1007_s10038_007_0171_0 crossref_primary_10_1038_srep09864 crossref_primary_10_1134_S1022795423070062 crossref_primary_10_1186_1471_2350_9_57 crossref_primary_10_1016_j_mito_2020_06_006 crossref_primary_10_1080_24701394_2016_1177038 crossref_primary_10_1038_ejhg_2009_63 crossref_primary_10_1161_CIRCULATIONAHA_107_756809 crossref_primary_10_1038_s10038_022_01011_6 crossref_primary_10_1016_j_mito_2010_01_003 crossref_primary_10_1016_j_mito_2009_06_003 crossref_primary_10_1017_erm_2017_5 crossref_primary_10_1016_j_mito_2007_06_002 crossref_primary_10_1007_s10545_009_1059_2 crossref_primary_10_1016_j_bbabio_2015_05_015 crossref_primary_10_3389_fonc_2020_572954 crossref_primary_10_1038_jhg_2009_143 crossref_primary_10_1016_S1474_4422_10_70083_1 crossref_primary_10_1007_s00438_014_0884_7 crossref_primary_10_1111_j_1447_0594_2010_00599_x |
| Cites_doi | 10.1016/j.mito.2004.09.001 10.1007/s00251-005-0048-3 10.1097/01.mol.0000162324.85290.ac 10.1196/annals.1293.031 10.1016/0169-328X(94)00209-W 10.1212/01.wnl.0000216132.95207.b4 10.1161/01.STR.21.4.637 10.1016/S0140-6736(05)79190-X 10.1006/bbrc.2002.6330 10.1016/S0140-6736(05)78211-8 10.1016/S0008-6363(02)00487-X 10.1146/annurev.genom.6.080604.162249 10.1159/000078749 10.1016/S1474-4422(04)00708-2 10.1126/science.185.4154.862 10.1101/gr.2286304 10.1016/j.cccn.2005.06.023 10.1161/01.STR.0000221714.96986.5f 10.1038/290457a0 10.1161/hs1101.098328 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.mito.2006.11.002 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EndPage | 79 |
| ExternalDocumentID | 17257906 10_1016_j_mito_2006_11_002 |
| Genre | Research Support, Non-U.S. Gov't Multicenter Study Journal Article |
| GeographicLocations | Japan |
| GeographicLocations_xml | – name: Japan |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29M 4.4 457 4G. 53G 5VS 7-5 71M 8P~ AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXUO AAYWO AAYXX ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ACDAQ ACGFO ACGFS ACIUM ACLOT ACRLP ACVFH ADBBV ADCNI ADEZE ADUVX AEBSH AEFWE AEHWI AEIPS AEKER AENEX AEUPX AFJKZ AFPUW AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CITATION CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SDF SDG SES SEW SPCBC SSU SSZ T5K UHS UNMZH ~G- ~HD AACTN AFKWA AJOXV AMFUW CGR CUY CVF ECM EIF NPM RIG 7X8 |
| ID | FETCH-LOGICAL-c367t-c94c2793313addda90ee3148dee60236265ff30e87684019d17fea9f2f54c0123 |
| ISSN | 1567-7249 |
| IngestDate | Wed Oct 01 14:41:40 EDT 2025 Wed Feb 19 01:44:51 EST 2025 Wed Oct 29 21:07:18 EDT 2025 Thu Apr 24 22:53:33 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1-2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c367t-c94c2793313addda90ee3148dee60236265ff30e87684019d17fea9f2f54c0123 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 17257906 |
| PQID | 70253508 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_70253508 pubmed_primary_17257906 crossref_primary_10_1016_j_mito_2006_11_002 crossref_citationtrail_10_1016_j_mito_2006_11_002 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-02-00 2007 Feb-Apr 20070201 |
| PublicationDateYYYYMMDD | 2007-02-01 |
| PublicationDate_xml | – month: 02 year: 2007 text: 2007-02-00 |
| PublicationDecade | 2000 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Mitochondrion |
| PublicationTitleAlternate | Mitochondrion |
| PublicationYear | 2007 |
| References | Itoh (10.1016/j.mito.2006.11.002_bib11) 2005; 57 Dunbar (10.1016/j.mito.2006.11.002_bib2) 2006; 363 Tanaka (10.1016/j.mito.2006.11.002_bib24) 2004; 14 Kimura (10.1016/j.mito.2006.11.002_bib12) 2004; 18 Tanaka (10.1016/j.mito.2006.11.002_bib23) 2002; 9 Fuku (10.1016/j.mito.2006.11.002_bib4) 2002; 290 Humphries (10.1016/j.mito.2006.11.002_bib9) 2004; 3 Koh (10.1016/j.mito.2006.11.002_bib14) 2002; 55 Kubo (10.1016/j.mito.2006.11.002_bib15) 2006; 66 Pakendorf (10.1016/j.mito.2006.11.002_bib20) 2005; 6 Morgan (10.1016/j.mito.2006.11.002_bib19) 2005; 16 Ikebe (10.1016/j.mito.2006.11.002_bib10) 1995; 28 10.1016/j.mito.2006.11.002_bib25 Tanaka (10.1016/j.mito.2006.11.002_bib22) 1998; 351 10.1016/j.mito.2006.11.002_bib5 10.1016/j.mito.2006.11.002_bib21 Majamaa (10.1016/j.mito.2006.11.002_bib17) 1998; 352 Finnila (10.1016/j.mito.2006.11.002_bib3) 2001; 458 Guo (10.1016/j.mito.2006.11.002_bib7) 2005; 5 Holt (10.1016/j.mito.2006.11.002_bib8) 1990; 46 Martinez-Fernandez (10.1016/j.mito.2006.11.002_bib18) 2001; 32 Kitamura (10.1016/j.mito.2006.11.002_bib13) 2006; 37 Liou (10.1016/j.mito.2006.11.002_bib16) 2004; 1011 Grantham (10.1016/j.mito.2006.11.002_bib6) 1974; 185 Anderson (10.1016/j.mito.2006.11.002_bib1) 1981; 290 |
| References_xml | – volume: 5 start-page: 15 year: 2005 ident: 10.1016/j.mito.2006.11.002_bib7 article-title: Mitochondrial genome polymorphisms associated with type 2 diabetes or obesity publication-title: Mitochondrion doi: 10.1016/j.mito.2004.09.001 – volume: 57 start-page: 717 year: 2005 ident: 10.1016/j.mito.2006.11.002_bib11 article-title: High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population publication-title: Immunogenetics doi: 10.1007/s00251-005-0048-3 – ident: 10.1016/j.mito.2006.11.002_bib5 – volume: 16 start-page: 193 year: 2005 ident: 10.1016/j.mito.2006.11.002_bib19 article-title: The genetics of stroke publication-title: Curr. Opin. Lipidol. doi: 10.1097/01.mol.0000162324.85290.ac – volume: 1011 start-page: 317 year: 2004 ident: 10.1016/j.mito.2006.11.002_bib16 article-title: Association of the mitochondrial DNA 16189 T to C variant with lacunar cerebral infarction: evidence from a hospital-based case-control study publication-title: Ann. NY. Acad. Sci. doi: 10.1196/annals.1293.031 – volume: 28 start-page: 281 year: 1995 ident: 10.1016/j.mito.2006.11.002_bib10 article-title: Point mutations of mitochondrial genome in Parkinson’s disease publication-title: Brain. Res. Mol. Brain. Res. doi: 10.1016/0169-328X(94)00209-W – volume: 66 start-page: 1539 year: 2006 ident: 10.1016/j.mito.2006.11.002_bib15 article-title: Decreasing incidence of lacunar vs. other types of cerebral infarction in a Japanese population publication-title: Neurology doi: 10.1212/01.wnl.0000216132.95207.b4 – ident: 10.1016/j.mito.2006.11.002_bib21 doi: 10.1161/01.STR.21.4.637 – volume: 352 start-page: 455 year: 1998 ident: 10.1016/j.mito.2006.11.002_bib17 article-title: Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine publication-title: Lancet doi: 10.1016/S0140-6736(05)79190-X – volume: 290 start-page: 1199 year: 2002 ident: 10.1016/j.mito.2006.11.002_bib4 article-title: Mitochondrial ATPase subunit 6 and cytochrome B gene polymorphisms in young obese adults publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2002.6330 – volume: 351 start-page: 185 year: 1998 ident: 10.1016/j.mito.2006.11.002_bib22 article-title: Mitochondrial genotype associated with longevity publication-title: Lancet doi: 10.1016/S0140-6736(05)78211-8 – volume: 55 start-page: 714 year: 2002 ident: 10.1016/j.mito.2006.11.002_bib14 article-title: Effects of estrogen on the vascular wall: vasomotor function and inflammation publication-title: Cardiovasc. Res. doi: 10.1016/S0008-6363(02)00487-X – volume: 6 start-page: 165 year: 2005 ident: 10.1016/j.mito.2006.11.002_bib20 article-title: Mitochondrial DNA and human evolution publication-title: Annu. Rev. Genomics. Hum. Genet. doi: 10.1146/annurev.genom.6.080604.162249 – volume: 18 start-page: 47 year: 2004 ident: 10.1016/j.mito.2006.11.002_bib12 article-title: Analysis of 16,922 patients with acute ischemic stroke and transient ischemic attack in Japan. A hospital-based prospective registration study publication-title: Cerebrovasc. Dis. doi: 10.1159/000078749 – volume: 458 start-page: 31 year: 2001 ident: 10.1016/j.mito.2006.11.002_bib3 article-title: Phylogenetic analysis of mitochondrial DNA in patients with an occipital stroke. Evaluation of mutations by using sequence data on the entire coding region publication-title: Mutat. Res. – volume: 46 start-page: 428 year: 1990 ident: 10.1016/j.mito.2006.11.002_bib8 article-title: A new mitochondrial disease associated with mitochondrial DNA heteroplasmy publication-title: Am. J. Hum. Genet. – volume: 3 start-page: 227 year: 2004 ident: 10.1016/j.mito.2006.11.002_bib9 article-title: Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches publication-title: Lancet. Neurol. doi: 10.1016/S1474-4422(04)00708-2 – volume: 9 start-page: 534 year: 2002 ident: 10.1016/j.mito.2006.11.002_bib23 article-title: Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria publication-title: J. Biomed. Sci. – ident: 10.1016/j.mito.2006.11.002_bib25 – volume: 185 start-page: 862 year: 1974 ident: 10.1016/j.mito.2006.11.002_bib6 article-title: Amino acid difference formula to help explain protein evolution publication-title: Science doi: 10.1126/science.185.4154.862 – volume: 14 start-page: 1832 year: 2004 ident: 10.1016/j.mito.2006.11.002_bib24 article-title: Mitochondrial genome variation in eastern Asia and the peopling of Japan publication-title: Genome. Res. doi: 10.1101/gr.2286304 – volume: 363 start-page: 71 year: 2006 ident: 10.1016/j.mito.2006.11.002_bib2 article-title: Applications of Luminex xMAP technology for rapid, high-throughput multiplexed nucleic acid detection publication-title: Clin. Chim. Acta doi: 10.1016/j.cccn.2005.06.023 – volume: 37 start-page: 1374 year: 2006 ident: 10.1016/j.mito.2006.11.002_bib13 article-title: Proportions of stroke subtypes among men and women ⩾40 years of age in an urban Japanese city in 1992, 1997, and 2002 publication-title: Stroke doi: 10.1161/01.STR.0000221714.96986.5f – volume: 290 start-page: 457 year: 1981 ident: 10.1016/j.mito.2006.11.002_bib1 article-title: Sequence and organization of the human mitochondrial genome publication-title: Nature doi: 10.1038/290457a0 – volume: 32 start-page: 2507 year: 2001 ident: 10.1016/j.mito.2006.11.002_bib18 article-title: Mitochondrial disease and stroke publication-title: Stroke doi: 10.1161/hs1101.098328 |
| SSID | ssj0017122 |
| Score | 1.9553664 |
| Snippet | Mitochondrion-derived reactive oxygen species possibly play an important role in the pathogenesis of atherosclerosis and atherothrombotic cerebral infarction,... |
| SourceID | proquest pubmed crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 72 |
| SubjectTerms | Aged Asian Continental Ancestry Group - genetics Atherosclerosis - genetics Cerebral Infarction - genetics DNA, Mitochondrial - genetics Female Haplotypes - genetics Humans Japan Logistic Models Male Middle Aged Multivariate Analysis Polymorphism, Single Nucleotide - genetics Risk Factors Thrombosis - genetics |
| Title | Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/17257906 https://www.proquest.com/docview/70253508 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier ScienceDirect Complete Freedom Collection issn: 1567-7249 databaseCode: ACRLP dateStart: 20010601 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.sciencedirect.com omitProxy: true ssIdentifier: ssj0017122 providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] issn: 1567-7249 databaseCode: AIKHN dateStart: 20010601 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.sciencedirect.com omitProxy: true ssIdentifier: ssj0017122 providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect (Elsevier) issn: 1567-7249 databaseCode: .~1 dateStart: 20010601 customDbUrl: isFulltext: true dateEnd: 99991231 titleUrlDefault: https://www.sciencedirect.com omitProxy: true ssIdentifier: ssj0017122 providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals issn: 1567-7249 databaseCode: AKRWK dateStart: 20010901 customDbUrl: isFulltext: true mediaType: online dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017122 providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEF6MQyCX0mfq9LWH3oKCnrvW0YQWE-oQQgLxSayk3dZ2bJlIOqQ_ob-6M9pdyXab0uQihCzt2prP89iZnY-Qz8LNJfcFc8JhDIc4E84wT5UjIHZmTIDebHZ4T87Z-Do8u4luer1fG1VLdZWeZD__uq_kKVKFayBX3CX7CMm2g8IFOAf5whEkDMf_kvEE_o6gvlZ5Q73xQ6yxATUuLo2Qp1wgPbJsejRj_bhm1tFVk-j1FciQsEwLvCGTd5hAxv4bCpBvCyDPwJIiQ-WxkkswJOWmJ7sxd5fJP8cVre9CU2FP60osWq0_FUuRN57qtICb5rMWOfWiNhmk2X29aK9PRFXWzULuGKaCR7YWKLitae50Kuhi7uvOpFbp8k1smQ2QWoVqJh9jjDXRzB9qXq84zE-WML9OKGEnVtfvjJpN5O_YurYC0Ra3zRMcA8k4GQRDSdOXdM8HC-H2yd7o9PLbRZuT4l6Tk2p_jtmCpasFd7_JtpvzQOzS-DBXz8kzE3zQkUbSC9KTq5dkX9OR3r8i6y080Q5PdERnJRXU4IkinqjGEwU80V08UYsn2uEJTqnFEzV4ek2uv365Oh07hpHDyQLGKyeLw8wHjR54AdjFXMSulAEE1LmUDKkIfBYpFbhyiOldCB5yjyspYuWrKMzQe39D-qtiJd8SGgkVyYDFbprzMIUxIG5XLFZMYhNDTw6IZ19gkpl29ciacps8LLoBOW6fWetmLf-8-5OVC3xWYqIM3kFRlwmHQCCAyGVADrW4utE4mLjYZUePmukdOej-GO9Jv7qr5QfwZav0owHZb3Bpo4Y |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mitochondrial+haplogroup+A+is+a+genetic+risk+factor+for+atherothrombotic+cerebral+infarction+in+Japanese+females&rft.jtitle=Mitochondrion&rft.au=Nishigaki%2C+Yutaka&rft.au=Yamada%2C+Yoshiji&rft.au=Fuku%2C+Noriyuki&rft.au=Matsuo%2C+Hitoshi&rft.date=2007-02-01&rft.issn=1567-7249&rft.volume=7&rft.issue=1-2&rft.spage=72&rft.epage=79&rft_id=info:doi/10.1016%2Fj.mito.2006.11.002&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_mito_2006_11_002 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1567-7249&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1567-7249&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1567-7249&client=summon |