Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats

Alzheimer’s disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impair-ment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer’s disease. Physical exercise is known to promote cell survival an...

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Bibliographic Details
Published inJournal of exercise rehabilitation Vol. 10; no. 1; pp. 2 - 8
Main Authors Kim, Bo-Kyun, Shin, Mal-Soon, Kim, Chang-Ju, Baek, Sang-Bin, Ko, Yeong-Chan, Kim, Young-Pyo
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Exercise Rehabilitation 01.02.2014
한국운동재활학회
Subjects
Original
심리과학
Treadmill exercise
Alzheimer’s disease
Neurogenesis
Apical dendritic length
Short-term memory
Online AccessGet full text
ISSN2288-176X
2288-1778
2288-1778
DOI10.12965/jer.140086

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Table of Contents:
  • Abstract INTRODUCTION MATERIALS AND METHODS Experimental animals and treatments ICV administration of Aβ25-35 Treadmill exercise protocol Step-through avoidance task Tissue preparation BrdU immunohistochemistr DCX immunohistochemistry Dendritic morphological analysis Western blot analysis for BDNF and TrkB Data analysis RESULTS Effect of treadmill exercise on short-term memory in the step-through avoidance task Effect of treadmill exercise on neurogenesis in the hippocampal dentate gyrus Effect of treadmill exercise on apical dendritic length in the hippocampal dentate gyrus Effect of treadmill exercise on expressions of BDNF and TrkB in the hippocampus DISCUSSION CONFLICT OF INEREST ACKNOWLEDGMENTS REFERENCES