The murine retinal pigment epithelium requires peroxisomal β-oxidation to maintain lysosomal function and prevent dedifferentiation - Kocherlakota, Sai; Das, Yannick; Swinkels, Daniëlle; Vanmunster, Maarten; Callens, Manon; Vinckier, Stefan; Vaz, Frédéric M.; Sinha, Debasish; Van Veldhoven, Paul P.; Fransen, Marc; Baes, Myriam (Proceedings of the National Academy of Sciences - PNAS, 2023)
Keywords: Animals; Anomalies; Degeneration; Deregulation; Energy shortages; Epithelium; Fatty acids; Gene therapy; Humans; Lipids; Lysosomes; Lysosomes - metabolism; Mammals; Mice; Mice, Knockout; Oxidation; Oxidative Stress; Phagocytosis - genetics; Photoreceptors; Pigments; Polyunsaturated fatty acids; Rapamycin; Retina; Retinal degeneration; Retinal pigment epithelium; Retinal Pigment Epithelium - metabolism; Retinopathy; TOR protein; peroxisomes; lipids; retinal degeneration; lysosomes; retinal pigment epithelium