Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA - Iguchi, Eriko; Takai, Atsushi; Oe, Natsumi; Fujii, Yosuke; Omatsu, Mayuki; Takeda, Haruhiko; Shimizu, Takahiro; Maruno, Takahisa; Nakanishi, Yuki; Yoshinaga, Masanori; Maruyama, Takashi; Marusawa, Hiroyuki; et al. (Proceedings of the National Academy of Sciences - PNAS, 2025)
Keywords: Adaptor Proteins, Signal Transducing; Animals; Antibiotics; Cell Proliferation; Colon; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Data analysis; Degradation; Deletion; Enterocytes; Epithelial cells; Epithelium; Extracellular signal-regulated kinase; Gene Expression Regulation, Neoplastic; Humans; Immune system; Inflammation; Interleukin 17; Interleukin-17 - genetics; Interleukin-17 - metabolism; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Ribonucleases - genetics; Ribonucleases - metabolism; RNA Stability; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Therapeutic targets; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptomes; Tumors; Ulcerative colitis; Regnase-1; colorectal cancer; IL-17