Safety of ovarian tissue transplantation in patients with borderline ovarian tumors
Abstract STUDY QUESTION Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure? SUMMARY ANSWER BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients. WHAT IS KNOWN ALREADY The risk of reintroducin...
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Published in | Human reproduction (Oxford) Vol. 33; no. 2; pp. 212 - 219 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.02.2018
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Subjects | |
Online Access | Get full text |
ISSN | 0268-1161 1460-2350 1460-2350 |
DOI | 10.1093/humrep/dex352 |
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Abstract | Abstract
STUDY QUESTION
Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?
SUMMARY ANSWER
BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients.
WHAT IS KNOWN ALREADY
The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring.
STUDY DESIGN, SIZE, DURATION
Prospective experimental study conducted in an academic research unit using ovarian tissue from 11 patients undergoing cryopreservation for BOTs.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Histology, immunohistochemistry (IHC) for mucin 1 (MUC1) and cytokeratin 7 (CK7) and molecular analysis by reverse transcription quantitative polymerase chain reaction (RT-qPCR) for CK7 and MUC1 were performed on frozen-thawed ovarian tissue from 11 patients. Long-term (5 months) xenografting of ovarian tissue in immunodeficient mice was performed. The xenografts were analyzed by histology, IHC and RT-qPCR, furthermore IHC for CD10, a marker of endometriosis, was performed on a selected sample.
MAIN RESULTS AND THE ROLE OF CHANCE
Analysis by histology, IHC and RT-qPCR indicated 10 of the ovarian tissue samples were negative. Analysis of the xenograft samples indicated nine were negative for malignant cells but in two xenografts glandular lesions were detected by histology. In these two xenografts, CK7 and MUC1 markers were demonstrated by IHC and CK7 expression also by RT-qPCR. A BOT was confirmed in the xenograft in which the original ovarian tissue was positive, while in the other case IHC demonstrated expression of endometriosis marker CD10.
LIMITATIONS, REASONS FOR CAUTION
Cryopreserved ovarian fragments cannot be tested before transplantation, therefore the preimplantation analysis cannot guarantee that all cryopreserved fragments will be free of BOT cells.
WIDER IMPLICATIONS OF THE FINDINGS
BOT cells can be found in cryopreserved ovarian tissue from BOT patients, therefore preimplantation analysis is an absolute prerequisite. Endometriosis can also be detected in cryopreserved ovarian tissue and caution should also be exercised in this scenario.
STUDY FUNDING/COMPETING INTEREST(S)
This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (FNRS-PDR Convention T.0077.14, Télévie Grant 7.4590.16 awarded to Rossella Masciangelo, and Grant 5/4/150/5 awarded to Marie-Madeleine Dolmans), the Fonds Speciaux de Recherche, and the Foundation Against Cancer. None of the authors have any conflicting interests to declare. |
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AbstractList | Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?
BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients.
The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring.
Prospective experimental study conducted in an academic research unit using ovarian tissue from 11 patients undergoing cryopreservation for BOTs.
Histology, immunohistochemistry (IHC) for mucin 1 (MUC1) and cytokeratin 7 (CK7) and molecular analysis by reverse transcription quantitative polymerase chain reaction (RT-qPCR) for CK7 and MUC1 were performed on frozen-thawed ovarian tissue from 11 patients. Long-term (5 months) xenografting of ovarian tissue in immunodeficient mice was performed. The xenografts were analyzed by histology, IHC and RT-qPCR, furthermore IHC for CD10, a marker of endometriosis, was performed on a selected sample.
Analysis by histology, IHC and RT-qPCR indicated 10 of the ovarian tissue samples were negative. Analysis of the xenograft samples indicated nine were negative for malignant cells but in two xenografts glandular lesions were detected by histology. In these two xenografts, CK7 and MUC1 markers were demonstrated by IHC and CK7 expression also by RT-qPCR. A BOT was confirmed in the xenograft in which the original ovarian tissue was positive, while in the other case IHC demonstrated expression of endometriosis marker CD10.
Cryopreserved ovarian fragments cannot be tested before transplantation, therefore the preimplantation analysis cannot guarantee that all cryopreserved fragments will be free of BOT cells.
BOT cells can be found in cryopreserved ovarian tissue from BOT patients, therefore preimplantation analysis is an absolute prerequisite. Endometriosis can also be detected in cryopreserved ovarian tissue and caution should also be exercised in this scenario.
This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (FNRS-PDR Convention T.0077.14, Télévie Grant 7.4590.16 awarded to Rossella Masciangelo, and Grant 5/4/150/5 awarded to Marie-Madeleine Dolmans), the Fonds Speciaux de Recherche, and the Foundation Against Cancer. None of the authors have any conflicting interests to declare. Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?STUDY QUESTIONIs transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients.SUMMARY ANSWERBOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients.The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring.WHAT IS KNOWN ALREADYThe risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring.Prospective experimental study conducted in an academic research unit using ovarian tissue from 11 patients undergoing cryopreservation for BOTs.STUDY DESIGN, SIZE, DURATIONProspective experimental study conducted in an academic research unit using ovarian tissue from 11 patients undergoing cryopreservation for BOTs.Histology, immunohistochemistry (IHC) for mucin 1 (MUC1) and cytokeratin 7 (CK7) and molecular analysis by reverse transcription quantitative polymerase chain reaction (RT-qPCR) for CK7 and MUC1 were performed on frozen-thawed ovarian tissue from 11 patients. Long-term (5 months) xenografting of ovarian tissue in immunodeficient mice was performed. The xenografts were analyzed by histology, IHC and RT-qPCR, furthermore IHC for CD10, a marker of endometriosis, was performed on a selected sample.PARTICIPANTS/MATERIALS, SETTING, METHODSHistology, immunohistochemistry (IHC) for mucin 1 (MUC1) and cytokeratin 7 (CK7) and molecular analysis by reverse transcription quantitative polymerase chain reaction (RT-qPCR) for CK7 and MUC1 were performed on frozen-thawed ovarian tissue from 11 patients. Long-term (5 months) xenografting of ovarian tissue in immunodeficient mice was performed. The xenografts were analyzed by histology, IHC and RT-qPCR, furthermore IHC for CD10, a marker of endometriosis, was performed on a selected sample.Analysis by histology, IHC and RT-qPCR indicated 10 of the ovarian tissue samples were negative. Analysis of the xenograft samples indicated nine were negative for malignant cells but in two xenografts glandular lesions were detected by histology. In these two xenografts, CK7 and MUC1 markers were demonstrated by IHC and CK7 expression also by RT-qPCR. A BOT was confirmed in the xenograft in which the original ovarian tissue was positive, while in the other case IHC demonstrated expression of endometriosis marker CD10.MAIN RESULTS AND THE ROLE OF CHANCEAnalysis by histology, IHC and RT-qPCR indicated 10 of the ovarian tissue samples were negative. Analysis of the xenograft samples indicated nine were negative for malignant cells but in two xenografts glandular lesions were detected by histology. In these two xenografts, CK7 and MUC1 markers were demonstrated by IHC and CK7 expression also by RT-qPCR. A BOT was confirmed in the xenograft in which the original ovarian tissue was positive, while in the other case IHC demonstrated expression of endometriosis marker CD10.Cryopreserved ovarian fragments cannot be tested before transplantation, therefore the preimplantation analysis cannot guarantee that all cryopreserved fragments will be free of BOT cells.LIMITATIONS, REASONS FOR CAUTIONCryopreserved ovarian fragments cannot be tested before transplantation, therefore the preimplantation analysis cannot guarantee that all cryopreserved fragments will be free of BOT cells.BOT cells can be found in cryopreserved ovarian tissue from BOT patients, therefore preimplantation analysis is an absolute prerequisite. Endometriosis can also be detected in cryopreserved ovarian tissue and caution should also be exercised in this scenario.WIDER IMPLICATIONS OF THE FINDINGSBOT cells can be found in cryopreserved ovarian tissue from BOT patients, therefore preimplantation analysis is an absolute prerequisite. Endometriosis can also be detected in cryopreserved ovarian tissue and caution should also be exercised in this scenario.This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (FNRS-PDR Convention T.0077.14, Télévie Grant 7.4590.16 awarded to Rossella Masciangelo, and Grant 5/4/150/5 awarded to Marie-Madeleine Dolmans), the Fonds Speciaux de Recherche, and the Foundation Against Cancer. None of the authors have any conflicting interests to declare.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (FNRS-PDR Convention T.0077.14, Télévie Grant 7.4590.16 awarded to Rossella Masciangelo, and Grant 5/4/150/5 awarded to Marie-Madeleine Dolmans), the Fonds Speciaux de Recherche, and the Foundation Against Cancer. None of the authors have any conflicting interests to declare. Abstract STUDY QUESTION Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure? SUMMARY ANSWER BOT cells were found in frozen-thawed and xenografted ovarian tissue in 1 of 11 BOT patients. WHAT IS KNOWN ALREADY The risk of reintroducing malignant cells upon ovarian tissue transplantation has been subject of debate for many years. Reimplantation of cryopreserved ovarian tissue from leukemia patients is unsafe, while results from studies of cryopreserved ovarian tissue from other forms of cancer, such as Hodgkin's lymphoma, are reassuring. STUDY DESIGN, SIZE, DURATION Prospective experimental study conducted in an academic research unit using ovarian tissue from 11 patients undergoing cryopreservation for BOTs. PARTICIPANTS/MATERIALS, SETTING, METHODS Histology, immunohistochemistry (IHC) for mucin 1 (MUC1) and cytokeratin 7 (CK7) and molecular analysis by reverse transcription quantitative polymerase chain reaction (RT-qPCR) for CK7 and MUC1 were performed on frozen-thawed ovarian tissue from 11 patients. Long-term (5 months) xenografting of ovarian tissue in immunodeficient mice was performed. The xenografts were analyzed by histology, IHC and RT-qPCR, furthermore IHC for CD10, a marker of endometriosis, was performed on a selected sample. MAIN RESULTS AND THE ROLE OF CHANCE Analysis by histology, IHC and RT-qPCR indicated 10 of the ovarian tissue samples were negative. Analysis of the xenograft samples indicated nine were negative for malignant cells but in two xenografts glandular lesions were detected by histology. In these two xenografts, CK7 and MUC1 markers were demonstrated by IHC and CK7 expression also by RT-qPCR. A BOT was confirmed in the xenograft in which the original ovarian tissue was positive, while in the other case IHC demonstrated expression of endometriosis marker CD10. LIMITATIONS, REASONS FOR CAUTION Cryopreserved ovarian fragments cannot be tested before transplantation, therefore the preimplantation analysis cannot guarantee that all cryopreserved fragments will be free of BOT cells. WIDER IMPLICATIONS OF THE FINDINGS BOT cells can be found in cryopreserved ovarian tissue from BOT patients, therefore preimplantation analysis is an absolute prerequisite. Endometriosis can also be detected in cryopreserved ovarian tissue and caution should also be exercised in this scenario. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (FNRS-PDR Convention T.0077.14, Télévie Grant 7.4590.16 awarded to Rossella Masciangelo, and Grant 5/4/150/5 awarded to Marie-Madeleine Dolmans), the Fonds Speciaux de Recherche, and the Foundation Against Cancer. None of the authors have any conflicting interests to declare. |
Author | Bosisio, Chiara Donnez, Jacques Dolmans, Marie-Madeleine Masciangelo, Rossella Amorim, Christiani A |
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Cites_doi | 10.1016/S0015-0282(00)00548-3 10.1038/nrendo.2013.205 10.1186/s13048-016-0226-y 10.1111/his.12182 10.1016/j.fertnstert.2013.03.030 10.1182/blood-2010-01-265751 10.1093/humrep/det340 10.1016/j.fertnstert.2009.11.032 10.1093/oxfordjournals.humrep.a138556 10.1016/j.ejca.2005.07.029 10.1016/S0140-6736(04)17222-X 10.1016/j.fertnstert.2014.10.045 10.5402/2011/140310 10.1016/j.fertnstert.2004.10.009 10.1093/humrep/dew193 10.1111/j.1365-2559.2010.03673.x 10.1007/s10815-016-0843-9 10.1016/j.fertnstert.2013.03.027 10.1136/jcp.55.5.391 10.1016/j.fertnstert.2011.05.003 10.1093/humupd/dms047 10.1016/j.ctrv.2016.06.010 10.1093/humrep/dep196 10.1016/j.fertnstert.2006.07.1503 10.1016/j.fertnstert.2017.03.017 10.1007/s10815-015-0544-9 10.1093/humrep/den459 10.1007/s10815-013-0065-3 10.1093/annonc/mdp267 10.1200/JCO.2001.19.10.2658 10.1016/j.bpobgyn.2011.12.006 10.1016/S0015-0282(03)00160-2 |
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Copyright | The Author(s) 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2017 The Author(s) 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com |
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Keywords | allografting minimal residual disease ovarian metastasis ovarian tissue cryopreservation fertility preservation borderline ovarian tumor |
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References | Zanetta ( key 20180328162834_dex352C33) 2001; 19 Dolmans ( key 20180328162834_dex352C6) 2013; 99 Donnez ( key 20180328162834_dex352C11) 2013; 99 Gosden ( key 20180328162834_dex352C16) 1994; 9 Dolmans ( key 20180328162834_dex352C5) 2010; 116 Jensen ( key 20180328162834_dex352C18) 2017; 34 Dolmans ( key 20180328162834_dex352C7) 2016; 31 Fain-Kahn ( key 20180328162834_dex352C13) 2009; 24 Dittrich ( key 20180328162834_dex352C4) 2015; 103 Halimi ( key 20180328162834_dex352C17) 2013; 63 Lotz ( key 20180328162834_dex352C21) 2011; 95 Chen ( key 20180328162834_dex352C2) 2016; 9 Donnez ( key 20180328162834_dex352C10) 2013; 9 Donnez ( key 20180328162834_dex352C9) 2004; 364 Rosendahl ( key 20180328162834_dex352C26) 2010; 94 Luyckx ( key 20180328162834_dex352C22) 2013; 30 Donnez ( key 20180328162834_dex352C8) 2003; 79 Sayasneh ( key 20180328162834_dex352C28) 2011; 2011 Taylor ( key 20180328162834_dex352C30) 1929; 48 Morice ( key 20180328162834_dex352C24) 2006; 42 Uzan ( key 20180328162834_dex352C32) 2010; 21 Nisolle ( key 20180328162834_dex352C25) 2000; 74 Kim ( key 20180328162834_dex352C19) 2010; 57 Fortin ( key 20180328162834_dex352C15) 2007; 87 Tropé ( key 20180328162834_dex352C31) 2012; 26 Mangili ( key 20180328162834_dex352C23) 2016; 49 Buis ( key 20180328162834_dex352C1) 2013; 28 Donnez ( key 20180328162834_dex352C12) 2015; 32 Kristensen ( key 20180328162834_dex352C20) 2017; 107 Sanchez-Serrano ( key 20180328162834_dex352C27) 2009; 24 Daraï ( key 20180328162834_dex352C3) 2013; 19 Fauvet ( key 20180328162834_dex352C14) 2005; 83 Sumathi ( key 20180328162834_dex352C29) 2002; 55 |
References_xml | – volume: 74 start-page: 122 year: 2000 ident: key 20180328162834_dex352C25 article-title: Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice publication-title: Fertil Steril doi: 10.1016/S0015-0282(00)00548-3 – volume: 9 start-page: 735 year: 2013 ident: key 20180328162834_dex352C10 article-title: Fertility preservation in women publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2013.205 – volume: 9 start-page: 16 year: 2016 ident: key 20180328162834_dex352C2 article-title: Fertility-sparing surgery for young patients with borderline ovarian tumors (BOTs): single institution experience publication-title: J Ovarian Res doi: 10.1186/s13048-016-0226-y – volume: 63 start-page: 534 year: 2013 ident: key 20180328162834_dex352C17 article-title: Claudin-18 overexpression in intestinal-type mucinous borderline tumour of the ovary publication-title: Histopathology doi: 10.1111/his.12182 – volume: 99 start-page: 1503 year: 2013 ident: key 20180328162834_dex352C11 article-title: Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.03.030 – volume: 116 start-page: 2908 year: 2010 ident: key 20180328162834_dex352C5 article-title: Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe publication-title: Blood doi: 10.1182/blood-2010-01-265751 – volume: 28 start-page: 3358 year: 2013 ident: key 20180328162834_dex352C1 article-title: Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis publication-title: Human Reprod doi: 10.1093/humrep/det340 – volume: 94 start-page: 2186 year: 2010 ident: key 20180328162834_dex352C26 article-title: Evidence of residual disease in cryopreserved ovarian cortex from female patients with leukemia publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2009.11.032 – volume: 9 start-page: 597 year: 1994 ident: key 20180328162834_dex352C16 article-title: Restoration of fertility to oophorectomised sheep by ovarian autografts stored at −196°C publication-title: Human Reprod doi: 10.1093/oxfordjournals.humrep.a138556 – volume: 42 start-page: 149 year: 2006 ident: key 20180328162834_dex352C24 article-title: Borderline tumours of the ovary and fertility publication-title: Eur J Cancer doi: 10.1016/j.ejca.2005.07.029 – volume: 364 start-page: 1405 year: 2004 ident: key 20180328162834_dex352C9 article-title: Livebirth after orthotopic transplantation of cryopreserved ovarian tissue publication-title: Lancet doi: 10.1016/S0140-6736(04)17222-X – volume: 103 start-page: 462 year: 2015 ident: key 20180328162834_dex352C4 article-title: Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2014.10.045 – volume: 2011 start-page: Article ID 140310 year: 2011 ident: key 20180328162834_dex352C28 article-title: Endometriosis and ovarian cancer: a systematic review publication-title: ISRN Obstet Gynecol doi: 10.5402/2011/140310 – volume: 83 start-page: 284 year: 2005 ident: key 20180328162834_dex352C14 article-title: Fertility after conservative treatment for borderline ovarian tumors: a French multicenter study publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2004.10.009 – volume: 31 start-page: 2292 year: 2016 ident: key 20180328162834_dex352C7 article-title: Evaluation of minimal disseminated disease in cryopreserved ovarian tissue from bone and soft tissue sarcoma patients publication-title: Human Reprod doi: 10.1093/humrep/dew193 – volume: 57 start-page: 587 year: 2010 ident: key 20180328162834_dex352C19 article-title: Endocervical-like (Mullerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation publication-title: Histopathology doi: 10.1111/j.1365-2559.2010.03673.x – volume: 34 start-page: 325 year: 2017 ident: key 20180328162834_dex352C18 article-title: 86 Successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children publication-title: J Assist Reprod Genet doi: 10.1007/s10815-016-0843-9 – volume: 99 start-page: 1514 year: 2013 ident: key 20180328162834_dex352C6 article-title: Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.03.027 – volume: 55 start-page: 391 year: 2002 ident: key 20180328162834_dex352C29 article-title: CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis publication-title: J Clin Pathol doi: 10.1136/jcp.55.5.391 – volume: 95 start-page: 2612 year: 2011 ident: key 20180328162834_dex352C21 article-title: Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice—no evidence of malignant cell contamination publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2011.05.003 – volume: 19 start-page: 151 year: 2013 ident: key 20180328162834_dex352C3 article-title: Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options publication-title: Hum Reprod Update doi: 10.1093/humupd/dms047 – volume: 49 start-page: 13 year: 2016 ident: key 20180328162834_dex352C23 article-title: Fertility preservation in women with borderline ovarian tumours publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2016.06.010 – volume: 24 start-page: 2238 year: 2009 ident: key 20180328162834_dex352C27 article-title: Malignant cells are not found in ovarian cortex from breast cancer patients undergoing ovarian cortex cryopreservation publication-title: Human Reprod doi: 10.1093/humrep/dep196 – volume: 87 start-page: 591 year: 2007 ident: key 20180328162834_dex352C15 article-title: Impact of infertility drugs after treatment of borderline ovarian tumors: results of a retrospective multicenter study publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2006.07.1503 – volume: 107 start-page: 1206 year: 2017 ident: key 20180328162834_dex352C20 article-title: Fertility preservation and refreezing of transplanted ovarian tissue—a potential new way of managing patients with low risk of malignant cell recurrence publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2017.03.017 – volume: 32 start-page: 1167 year: 2015 ident: key 20180328162834_dex352C12 article-title: Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice publication-title: J Assist Reprod Genet doi: 10.1007/s10815-015-0544-9 – volume: 24 start-page: 850 year: 2009 ident: key 20180328162834_dex352C13 article-title: Feasibility of ovarian cryopreservation in borderline ovarian tumours publication-title: Human Reprod doi: 10.1093/humrep/den459 – volume: 30 start-page: 1289 year: 2013 ident: key 20180328162834_dex352C22 article-title: Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study publication-title: J Assist Reprod Genet doi: 10.1007/s10815-013-0065-3 – volume: 48 start-page: 204 year: 1929 ident: key 20180328162834_dex352C30 article-title: Malignant and semi-malignant tumours of the ovary publication-title: Surg Gynecol Obstet – volume: 21 start-page: 55 year: 2010 ident: key 20180328162834_dex352C32 article-title: Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary publication-title: Ann Oncol doi: 10.1093/annonc/mdp267 – volume: 19 start-page: 2658 year: 2001 ident: key 20180328162834_dex352C33 article-title: Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.10.2658 – volume: 26 start-page: 325 year: 2012 ident: key 20180328162834_dex352C31 article-title: Borderline ovarian tumours publication-title: Best Pract Res Clin Obstet Gynaecol doi: 10.1016/j.bpobgyn.2011.12.006 – volume: 79 start-page: 1216 year: 2003 ident: key 20180328162834_dex352C8 article-title: Safety of conservative management and fertility outcome in women with borderline tumors of the ovary publication-title: Fertil Steril doi: 10.1016/S0015-0282(03)00160-2 |
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Snippet | Abstract
STUDY QUESTION
Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?
SUMMARY ANSWER... Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure? BOT cells were found in frozen-thawed... Is transplantation of cryopreserved ovarian tissue from patients with borderline ovarian tumors (BOTs) a safe procedure?STUDY QUESTIONIs transplantation of... |
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SubjectTerms | Adult Animals Cryopreservation Female Fertility Preservation - adverse effects Fertility Preservation - methods Humans Immunohistochemistry Keratin-7 - genetics Keratin-7 - metabolism Mice Mice, SCID Mucin-1 - genetics Mucin-1 - metabolism Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Ovary - metabolism Ovary - pathology Ovary - transplantation Prospective Studies Reverse Transcriptase Polymerase Chain Reaction Safety Tissue Transplantation - adverse effects Tissue Transplantation - methods Transplantation, Heterologous |
Title | Safety of ovarian tissue transplantation in patients with borderline ovarian tumors |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29281007 https://www.proquest.com/docview/1981052093 |
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