Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity - Kuppusamy, Maniselvan; Ottolini, Matteo; Chen, Yen-Lin; Daneva, Zdravka; Li, Jie; Heng-Mae Cheung, Caroline; Rios, Natalia; Radi, Rafael; Garcia, Gracie; Nwafor, Divine; Park, Min S.; Tumanov, Alexei V.; et al. (Circulation research, 2025)
Keywords: Animals; Blood Pressure; Cells, Cultured; Diet, High-Fat; Endothelial Cells - metabolism; Endothelium, Vascular - metabolism; Female; Humans; Hypertension - etiology; Hypertension - metabolism; Hypertension - physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiopathology; Myocytes, Smooth Muscle - metabolism; Obesity - metabolism; Obesity - physiopathology; Paracrine Communication; Receptors, Tumor Necrosis Factor, Type I - genetics; Receptors, Tumor Necrosis Factor, Type I - metabolism; Signal Transduction; TRPV Cation Channels - metabolism; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; tumor necrosis factor-alpha; blood pressure; endothelium; muscle, smooth; inflammation; obesity