Label-free glucose sensing with temperature modulation

• Published in: Current applied physics Vol. 14; no. 11; pp. 1553 - 1556
• Main Authors: Park, Hyung Goo, Yoon, Hyong Seo, Ji, Jae-hoon, Sim, Heung Bo, Kim, Jae Hun, Jun, Seong Chan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2014; 한국물리학회
• Subjects: Devices; Electrical resistance; Electrical resistivity; Glucose; Glucose sensing; Human body; Joule heating; Label-free bio sensor; Modulation; Resistivity; 물리학; Label-free bio sensor; Glucose sensing; Joule heating
• ISSN: 1567-1739; 1878-1675
• DOI: 10.1016/j.cap.2014.09.006

Label-free detection of glucose molar concentration was carefully studied with a device which was designed to modulate temperature in a local area by Joule heating from room temperature to human body temperature. Very small amount of glucose concentration up to sub-millimolar range was detected based on the glucose concentration dependent electrical resistance change with the temperature modulation since it allowed more electrical conductivity enhancement for lower glucose concentration. •Very small amount of glucose concentration up to sub-millimolar range was detected.•The local Joule heating changed the electrical conductivity of glucose solution.•The solution with lower concentration showed further conductivity enhancement.•The concentration was distinguished based on the electrical conductivity variation.