Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant

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Published inInternal medicine journal Vol. 43; no. 3; pp. 345 - 347
Main Authors Daniel, A., d' Emden, M., Duncan, E.
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.03.2013
Subjects
Adolescent
Gigantism - diagnosis
Gigantism - drug therapy
Gigantism - metabolism
Hormone Antagonists - therapeutic use
Human Growth Hormone - analogs & derivatives
Human Growth Hormone - therapeutic use
Humans
Male
Membrane Proteins - antagonists & inhibitors
Membrane Proteins - physiology
Treatment Outcome
Online AccessGet full text
ISSN1444-0903
1445-5994
1445-5994
DOI10.1111/imj.12077

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Author d' Emden, M.
Duncan, E.
Daniel, A.
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  surname: Duncan
  fullname: Duncan, E.
  organization: Department of Endocrinology, Royal Brisbane and Women's Hospital, Queensland, Brisbane, Australia
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Cites_doi 10.1016/S0026-0495(96)90086-4
10.1055/s-2007-956172
10.1159/000271919
10.1210/jc.2011-2508
10.2165/11318510-000000000-00000
10.1210/jc.2010-2443
10.1111/j.1365-2265.2005.02199.x
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Bergamaschi S, Ronchi CL, Giavoli C, Ferrante E, Verrua E, Ferrari DI et al. Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy. Horm Res Paediatr 2010; 73: 74-79.
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Feelders RA, Hofland LJ, van Aken MO, Neggers SJ, Lamberts SW, de Herder WW et al. Medical therapy of acromegaly: efficacy and safety of somatostatin analogues. Drugs 2009; 69: 2207-2226.
Mussig K, Gallwitz B, Honegger J, Strasburger CJ, Bidlingmaier M, Machicao F et al. Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma. Exp Clin Endocrinol Diabetes 2007; 115: 198-202.
Minniti G, Jaffrain-Rea ML, Osti M, Esposito V, Santoro A, Solda F et al. The long-term efficacy of conventional radiotherapy in patients with GH-secreting pituitary adenomas. Clin Endocrinol (Oxf) 2005; 62: 210-216.
van der Lely AJ, Biller BM, Brue T, Buchfelder M, Ghigo E, Gomez R et al. Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 2012; 97: 1589-1597.
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2011; 96
2007; 115
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2010; 73
2012; 97
1996; 45
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References_xml – reference: Sandret L, Maison P, Chanson P. Place of cabergoline in acromegaly: a meta-analysis. J Clin Endocrinol Metab 2011; 96: 1327-1335.
– reference: van der Lely AJ, Biller BM, Brue T, Buchfelder M, Ghigo E, Gomez R et al. Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 2012; 97: 1589-1597.
– reference: Feelders RA, Hofland LJ, van Aken MO, Neggers SJ, Lamberts SW, de Herder WW et al. Medical therapy of acromegaly: efficacy and safety of somatostatin analogues. Drugs 2009; 69: 2207-2226.
– reference: Bergamaschi S, Ronchi CL, Giavoli C, Ferrante E, Verrua E, Ferrari DI et al. Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy. Horm Res Paediatr 2010; 73: 74-79.
– reference: Mussig K, Gallwitz B, Honegger J, Strasburger CJ, Bidlingmaier M, Machicao F et al. Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma. Exp Clin Endocrinol Diabetes 2007; 115: 198-202.
– reference: Fahlbusch R, Honegger J, Buchfelder M. Acromegaly-the place of the neurosurgeon. Metabolism 1996; 45: 65-66.
– reference: Minniti G, Jaffrain-Rea ML, Osti M, Esposito V, Santoro A, Solda F et al. The long-term efficacy of conventional radiotherapy in patients with GH-secreting pituitary adenomas. Clin Endocrinol (Oxf) 2005; 62: 210-216.
– volume: 96
  start-page: 1327
  year: 2011
  end-page: 1335
  article-title: Place of cabergoline in acromegaly: a meta‐analysis
  publication-title: J Clin Endocrinol Metab
– volume: 115
  start-page: 198
  year: 2007
  end-page: 202
  article-title: Pegvisomant treatment in gigantism caused by a growth hormone‐secreting giant pituitary adenoma
  publication-title: Exp Clin Endocrinol Diabetes
– volume: 97
  start-page: 1589
  year: 2012
  end-page: 1597
  article-title: Long‐term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY
  publication-title: J Clin Endocrinol Metab
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  article-title: Medical therapy of acromegaly: efficacy and safety of somatostatin analogues
  publication-title: Drugs
– volume: 73
  start-page: 74
  year: 2010
  end-page: 79
  article-title: Eight‐year follow‐up of a child with a GH/prolactin‐secreting adenoma: efficacy of pegvisomant therapy
  publication-title: Horm Res Paediatr
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  article-title: Acromegaly–the place of the neurosurgeon
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  article-title: The long‐term efficacy of conventional radiotherapy in patients with GH‐secreting pituitary adenomas
  publication-title: Clin Endocrinol (Oxf)
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  doi: 10.1210/jc.2011-2508
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SubjectTerms Adolescent
Gigantism - diagnosis
Gigantism - drug therapy
Gigantism - metabolism
Hormone Antagonists - therapeutic use
Human Growth Hormone - analogs & derivatives
Human Growth Hormone - therapeutic use
Humans
Male
Membrane Proteins - antagonists & inhibitors
Membrane Proteins - physiology
Treatment Outcome
Title Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant
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