Association of vitamin D status at birth and respiratory outcomes in preterm infants

• Published in: Clinical and experimental pediatrics Vol. 62; no. 5; pp. 162 - 163
• Main Author: Park, Sook-Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) Clinical and Experimental Pediatics / Korean Pediatric Society 01.05.2019; Korean Pediatric Society; 대한소아청소년과학회
• Subjects: Clinical outcomes; Clinical trials; Conflicts of interest; Gastroenterology; Hepatology; Hospitalization; Lung diseases; Morbidity; Mortality; Newborn babies; Nutrition; Pediatrics; Pregnancy; Premature babies; Respiratory distress syndrome; Sepsis; Surfactants; Ventilators; Vitamin D; Vitamin deficiency; 소아과학
• ISSN: 1738-1061; 2092-7258; 2713-4148
• DOI: 10.3345/kjp.2018.07311

Vitamin D deficiency increases the loss of innate and adaptive immune function and susceptibility of autoimmune disease and infection, which results in an association with higher risk of sepsis, milk sensitization, respiratory infection or wheeze, type 1 diabetes, multiple sclerosis, and cardiovascular diseases [1]. The major determining factor of neonatal vitamin D level at birth is maternal vitamin D status, as vitamin D transfers to the fetus during third trimester; this suggests that preterm infants are at higher risk of vitamin D deficiency than full-term infants. [...]vitamin D status at birth may be associated with respiratory morbidities; thus, further studies should be needed to identify the optimal dose and duration of vitamin D supplementation to improve respiratory outcomes in Korean preterm infants.