Comprehensive review on various strategies for antimalarial drug discovery

• Published in: European journal of medicinal chemistry Vol. 125; pp. 1300 - 1320
• Main Authors: Mishra, Mitali, Mishra, Vikash K., Kashaw, Varsha, Iyer, Arun K., Kashaw, Sushil Kumar
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.01.2017
• Subjects: Animals; Antimalarial; Antimalarials - chemistry; Antimalarials - pharmacology; Antimalarials - therapeutic use; Biological Products - chemistry; Biological Products - pharmacology; Biological Products - therapeutic use; Drug Discovery - methods; Drug Resistance; Humans; Malaria - drug therapy; Malaria - metabolism; Malaria - prevention & control; Malaria Vaccines - pharmacology; Malaria Vaccines - therapeutic use; Molecular Targeted Therapy; Molecular targets; Plasmodium - drug effects; Plasmodium - physiology; Plasmodium falciparum; Vaccine; Antimalarial; CSp; HPPK; DHPS; CDRI; Vaccine; Drug resistance; CQ; Molecular targets; DHFR; Plasmodium falciparum; DHOD; DXR
• ISSN: 0223-5234; 1768-3254; 1768-3254
• DOI: 10.1016/j.ejmech.2016.11.025

The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well. The present review article focuses on various approaches of antimalarial drug development to fight against the problem of drug resistance. [Display omitted] •Malaria imposes a massive global health burden due to emergence & spread of drug resistance.•Various approaches are investigated to seek out the new class of antimalarial to overcome the resistance.•Malaria vaccine development is hope for successful control of malaria.