Comprehensive review on various strategies for antimalarial drug discovery

The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds....

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Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 125; pp. 1300 - 1320
Main Authors Mishra, Mitali, Mishra, Vikash K., Kashaw, Varsha, Iyer, Arun K., Kashaw, Sushil Kumar
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 05.01.2017
Subjects
Animals
Antimalarial
Antimalarials - chemistry
Antimalarials - pharmacology
Antimalarials - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Drug Discovery - methods
Drug Resistance
Humans
Malaria - drug therapy
Malaria - metabolism
Malaria - prevention & control
Malaria Vaccines - pharmacology
Malaria Vaccines - therapeutic use
Molecular Targeted Therapy
Molecular targets
Plasmodium - drug effects
Plasmodium - physiology
Plasmodium falciparum
Vaccine
Antimalarial
CSp
HPPK
DHPS
CDRI
Vaccine
Drug resistance
CQ
Molecular targets
DHFR
Plasmodium falciparum
DHOD
DXR
Online AccessGet full text
ISSN0223-5234
1768-3254
1768-3254
DOI10.1016/j.ejmech.2016.11.025

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Abstract The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well. The present review article focuses on various approaches of antimalarial drug development to fight against the problem of drug resistance. [Display omitted] •Malaria imposes a massive global health burden due to emergence & spread of drug resistance.•Various approaches are investigated to seek out the new class of antimalarial to overcome the resistance.•Malaria vaccine development is hope for successful control of malaria.
AbstractList The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well.The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well.
The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well.
The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead to a massive global health burden. Till now, malaria control has relied upon the traditional quinoline, antifolate and artemisinin compounds. Very few new antimalarials were developed in the past 50 years. Among recent approaches, identification of novel chemotherapeutic targets, exploration of natural products with medicinal significance, covalent bitherapy having a dual mode of action into a single hybrid molecule and malaria vaccine development are explored heavily. The proper execution of these approaches and proper investment from international agencies will accelerate the discovery of drugs that provide new hope for the control or eventual eradication of this global infectious disease. This review explores various strategies for assessment and development of new antimalarial drugs. Current status and scientific value of previous approaches are systematically reviewed and new approaches provide a pragmatic forecast for future developments are introduced as well. The present review article focuses on various approaches of antimalarial drug development to fight against the problem of drug resistance. [Display omitted] •Malaria imposes a massive global health burden due to emergence & spread of drug resistance.•Various approaches are investigated to seek out the new class of antimalarial to overcome the resistance.•Malaria vaccine development is hope for successful control of malaria.
Author Mishra, Vikash K.
Mishra, Mitali
Kashaw, Varsha
Iyer, Arun K.
Kashaw, Sushil Kumar
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  fullname: Mishra, Vikash K.
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  organization: Department of Pharmaceutical Sciences, Dr. Harisingh Gour University (A Central University), Sagar, MP, India
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1768-3254
IngestDate Sat Sep 27 21:35:36 EDT 2025
Wed Feb 19 01:57:10 EST 2025
Wed Oct 01 04:19:46 EDT 2025
Thu Apr 24 22:54:48 EDT 2025
Fri Feb 23 02:20:09 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Antimalarial
CSp
HPPK
DHPS
CDRI
Vaccine
Drug resistance
CQ
Molecular targets
DHFR
Plasmodium falciparum
DHOD
DXR
Language English
License Copyright © 2016 Elsevier Masson SAS. All rights reserved.
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Snippet The resistance of malaria parasites to existing drugs carries on growing and progressively limiting our ability to manage this severe disease and finally lead...
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SubjectTerms Animals
Antimalarial
Antimalarials - chemistry
Antimalarials - pharmacology
Antimalarials - therapeutic use
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Drug Discovery - methods
Drug Resistance
Humans
Malaria - drug therapy
Malaria - metabolism
Malaria - prevention & control
Malaria Vaccines - pharmacology
Malaria Vaccines - therapeutic use
Molecular Targeted Therapy
Molecular targets
Plasmodium - drug effects
Plasmodium - physiology
Plasmodium falciparum
Vaccine
Title Comprehensive review on various strategies for antimalarial drug discovery
URI https://dx.doi.org/10.1016/j.ejmech.2016.11.025
https://www.ncbi.nlm.nih.gov/pubmed/27886547
https://www.proquest.com/docview/1844028214
Volume 125
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