Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions

The cadherin-catenin adhesion complex is the key component of the intercellular junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and t...

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Published inCold Spring Harbor perspectives in biology Vol. 9; no. 5; p. a028738
Main Authors Mège, René Marc, Ishiyama, Noboru
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.05.2017
Subjects
Actins - metabolism
Adherens Junctions - physiology
Animals
Cadherins - metabolism
Catenins - metabolism
Cell Adhesion
Cytoskeleton - metabolism
Humans
Mechanotransduction, Cellular
Microtubules - metabolism
PERSPECTIVES
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ISSN1943-0264
1943-0264
DOI10.1101/cshperspect.a028738

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Abstract The cadherin-catenin adhesion complex is the key component of the intercellular junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and thereby contributes to mechanical coupling between cells which drives many morphogenetic events and tissue repair. Mechanotransduction at cadherin adhesions enables cells to sense, signal, and respond to physical changes in their environment. Central to this process is the dynamic link of the complex to actin filaments (F-actin), themselves structurally dynamic and subject to tension generated by myosin II motors. We discuss in this review recent breakthroughs in understanding molecular and cellular aspects of the organization of the core cadherin-catenin complex in junctions, its association to F-actin, its mechanosensitive regulation, and dynamics.
AbstractList The cadherin-catenin adhesion complex is the key component of the intercellular junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and thereby contributes to mechanical coupling between cells which drives many morphogenetic events and tissue repair. Mechanotransduction at cadherin adhesions enables cells to sense, signal, and respond to physical changes in their environment. Central to this process is the dynamic link of the complex to actin filaments (F-actin), themselves structurally dynamic and subject to tension generated by myosin II motors. We discuss in this review recent breakthroughs in understanding molecular and cellular aspects of the organization of the core cadherin-catenin complex in junctions, its association to F-actin, its mechanosensitive regulation, and dynamics.
The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and thereby contributes to mechanical coupling between cells which drives many morphogenetic events and tissue repair. Mechanotransduction at cadherin adhesions enables cells to sense, signal, and respond to physical changes in their environment. Central to this process is the dynamic link of the complex to actin filaments (F-actin), themselves structurally dynamic and subject to tension generated by myosin II motors. We discuss in this review recent breakthroughs in understanding molecular and cellular aspects of the organization of the core cadherin-catenin complex in adherens junctions, its association to F-actin, its mechanosensitive regulation, and dynamics. Adherens junctions, composed mainly of cadherins and catenins, are cell junctions that are linked to F-actin. Recent work has provided a deeper understanding of their organization, mechanosensitive regulation, and dynamics.
The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and thereby contributes to mechanical coupling between cells which drives many morphogenetic events and tissue repair. Mechanotransduction at cadherin adhesions enables cells to sense, signal, and respond to physical changes in their environment. Central to this process is the dynamic link of the complex to actin filaments (F-actin), themselves structurally dynamic and subject to tension generated by myosin II motors. We discuss in this review recent breakthroughs in understanding molecular and cellular aspects of the organization of the core cadherin-catenin complex in adherens junctions, its association to F-actin, its mechanosensitive regulation, and dynamics.
Author Mège, René Marc
Ishiyama, Noboru
AuthorAffiliation 2 Princess Margaret Cancer Centre, University Health Network, TMDT 4-902, Toronto, Ontario, Canada
1 Institut Jacques Monod (IJM), CNRS UMR 7592 and Université Paris Diderot, Paris, France
AuthorAffiliation_xml – name: 1 Institut Jacques Monod (IJM), CNRS UMR 7592 and Université Paris Diderot, Paris, France
– name: 2 Princess Margaret Cancer Centre, University Health Network, TMDT 4-902, Toronto, Ontario, Canada
Author_xml – sequence: 1
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  surname: Mège
  fullname: Mège, René Marc
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  givenname: Noboru
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  fullname: Ishiyama, Noboru
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28096263$$D View this record in MEDLINE/PubMed
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Snippet The cadherin-catenin adhesion complex is the key component of the intercellular junction (AJ) that contributes both to tissue stability and dynamic cell...
The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic...
The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic...
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StartPage a028738
SubjectTerms Actins - metabolism
Adherens Junctions - physiology
Animals
Cadherins - metabolism
Catenins - metabolism
Cell Adhesion
Cytoskeleton - metabolism
Humans
Mechanotransduction, Cellular
Microtubules - metabolism
PERSPECTIVES
Title Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions
URI https://www.ncbi.nlm.nih.gov/pubmed/28096263
https://www.proquest.com/docview/1861567182
https://pubmed.ncbi.nlm.nih.gov/PMC5411698
Volume 9
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