The source of the nitrogen atom for the biosynthesis of anthranilic acid
Chorismic acid was converted into anthranilic acid using cell-free extracts of Aerobacter aerogenes and l-[ amide- 15N]glutamine as nitrogen source. Mass spectroscopy of the anthranilic acid showed that the amide-nitrogen of glutamine was incorporated. NH 4+ ions were also found effective as a nitro...
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| Published in | Biochimica et biophysica acta Vol. 93; no. 1; pp. 78 - 84 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
09.10.1964
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/0304-4165(64)90262-4 |
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| Abstract | Chorismic acid was converted into anthranilic acid using cell-free extracts of
Aerobacter aerogenes and
l-[
amide-
15N]glutamine as nitrogen source. Mass spectroscopy of the anthranilic acid showed that the amide-nitrogen of glutamine was incorporated. NH
4+ ions were also found effective as a nitrogen source. Anthranilic acid synthesis with NH
4+, unlike that with glutamine, was not inhibited by 6-diazo-5-oxo-
l-nor-leucine. End-product inhibition of the conversion of chorismic acid into anthranilic acid by
l-tryptophan was effective with either nitrogen source. |
|---|---|
| AbstractList | Chorismic acid was converted into anthranilic acid using cell-free extracts of
Aerobacter aerogenes and
l-[
amide-
15N]glutamine as nitrogen source. Mass spectroscopy of the anthranilic acid showed that the amide-nitrogen of glutamine was incorporated. NH
4+ ions were also found effective as a nitrogen source. Anthranilic acid synthesis with NH
4+, unlike that with glutamine, was not inhibited by 6-diazo-5-oxo-
l-nor-leucine. End-product inhibition of the conversion of chorismic acid into anthranilic acid by
l-tryptophan was effective with either nitrogen source. |
| Author | Shannon, J.S. Gibson, F. Jackman, L.M. Edwards, J.M. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14249169$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0006-291X(61)90235-2 10.1021/ja00875a037 10.1021/ja01516a070 10.1021/bi00905a026 10.1038/198388a0 10.1042/bj0890229 |
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| Keywords | AMMONIA ANTHRANILIC ACID GLUTAMINE METABOLISM AEROBACTER AEROGENES EXPERIMENTAL LAB STUDY CHEMISTRY NITROGEN RADIOISOTOPES LEUCINE |
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| References | Srinivasan (BIB4) 1959; 81 Dawson, Elliott, Elliott, Jones (BIB9) 1959 Beynon, Lestes, Saunders, Williams (BIB14) 1963; Vol. 2 in the press. F. Gibson, Jackman (BIB3) 1963; 198 Biemann, Deffner (BIB7) 1961; 4 , Shannon (BIB13) 1963 Rivera, Srinivasan (BIB5) 1963; 2 Morgan, Gibson, Gibson (BIB6) 1963; 89 Beynon (BIB11) 1960 Biemann, McCloskey (BIB8) 1962; 84 Biemann (BIB12) 1962 Field, Franklin (BIB10) 1957 Gibson (10.1016/0304-4165(64)90262-4_BIB3) 1963; 198 Beynon (10.1016/0304-4165(64)90262-4_BIB14) 1963; Vol. 2 Dawson (10.1016/0304-4165(64)90262-4_BIB9) 1959 Beynon (10.1016/0304-4165(64)90262-4_BIB11) 1960 Biemann (10.1016/0304-4165(64)90262-4_BIB12) 1962 Biemann (10.1016/0304-4165(64)90262-4_BIB8) 1962; 84 10.1016/0304-4165(64)90262-4_BIB2 10.1016/0304-4165(64)90262-4_BIB1 Field (10.1016/0304-4165(64)90262-4_BIB10) 1957 Morgan (10.1016/0304-4165(64)90262-4_BIB6) 1963; 89 Biemann (10.1016/0304-4165(64)90262-4_BIB7) 1961; 4 Srinivasan (10.1016/0304-4165(64)90262-4_BIB4) 1959; 81 Rivera (10.1016/0304-4165(64)90262-4_BIB5) 1963; 2 Shannon (10.1016/0304-4165(64)90262-4_BIB13) 1963 |
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| Snippet | Chorismic acid was converted into anthranilic acid using cell-free extracts of
Aerobacter aerogenes and
l-[
amide-
15N]glutamine as nitrogen source. Mass... |
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| SubjectTerms | Ammonia Chemical Phenomena Chemistry Enterobacter aerogenes Glutamine Leucine Metabolism Nitrogen OldMedline ortho-Aminobenzoates Radioisotopes |
| Title | The source of the nitrogen atom for the biosynthesis of anthranilic acid |
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