Topical fluoride varnishes promote several biological responses on human gingival cells
•Different fluoride varnishes exhibit different biological effects and cytotoxicity on human gingival fibroblasts.•hGFs show better biocompatibility after exposition to Fixofluor and Duraphat.•In vitro investigations are required in order to compare the fluoride varnishes biological properties. To c...
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| Published in | Annals of anatomy Vol. 237; p. 151723 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Elsevier GmbH
01.09.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0940-9602 1618-0402 1618-0402 |
| DOI | 10.1016/j.aanat.2021.151723 |
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| Abstract | •Different fluoride varnishes exhibit different biological effects and cytotoxicity on human gingival fibroblasts.•hGFs show better biocompatibility after exposition to Fixofluor and Duraphat.•In vitro investigations are required in order to compare the fluoride varnishes biological properties.
To compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human fibroblasts: Cervitec F, Fixofluor, Fluor Protector S and Duraphat.
Human gingival fibroblasts (hGF) were exposed to different concentrations of fluoride varnishes extracts. Biological assays, including MTT and IC50 value determination, annexin-V/7-AAD staining, cell migration and F-actin staining with phalloidin were carried out. Statistical analyses were performed using one-way ANOVA and Tukey’s post hoc test.
At 4% concentration, all of the fluoride varnishes extracts affected fibroblasts metabolic activity, exhibiting a high degree of cytotoxicity at all measured time points. At 0.1% and 1%, Duraphat and Fixofluor or Fluor Protector S and Cervitec F exerted the lowest or highest cytotoxic effects, respectively. Similar effects were evidenced when induction of apoptosis/necrosis and cell migration assays were analyzed. Immunocytochemical assays revealed a similar number of fibroblasts, without changes in the morphology and F-actin content at 0.1% concentration of all tested materials, while at 1% concentration, Fluor Protector S and Cervitec F showed few cells with aberrant morphology or non-adhered cells, respectively.
Different commercial topical fluoride varnishes with the same therapeutic indication may exhibit different biological effects and cytotoxicity on fibroblasts. |
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| AbstractList | To compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human fibroblasts: Cervitec F, Fixofluor, Fluor Protector S and Duraphat.OBJECTIVETo compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human fibroblasts: Cervitec F, Fixofluor, Fluor Protector S and Duraphat.Human gingival fibroblasts (hGF) were exposed to different concentrations of fluoride varnishes extracts. Biological assays, including MTT and IC50 value determination, annexin-V/7-AAD staining, cell migration and F-actin staining with phalloidin were carried out. Statistical analyses were performed using one-way ANOVA and Tukey's post hoc test.MATERIAL AND METHODSHuman gingival fibroblasts (hGF) were exposed to different concentrations of fluoride varnishes extracts. Biological assays, including MTT and IC50 value determination, annexin-V/7-AAD staining, cell migration and F-actin staining with phalloidin were carried out. Statistical analyses were performed using one-way ANOVA and Tukey's post hoc test.At 4% concentration, all of the fluoride varnishes extracts affected fibroblasts metabolic activity, exhibiting a high degree of cytotoxicity at all measured time points. At 0.1% and 1%, Duraphat and Fixofluor or Fluor Protector S and Cervitec F exerted the lowest or highest cytotoxic effects, respectively. Similar effects were evidenced when induction of apoptosis/necrosis and cell migration assays were analyzed. Immunocytochemical assays revealed a similar number of fibroblasts, without changes in the morphology and F-actin content at 0.1% concentration of all tested materials, while at 1% concentration, Fluor Protector S and Cervitec F showed few cells with aberrant morphology or non-adhered cells, respectively.RESULTSAt 4% concentration, all of the fluoride varnishes extracts affected fibroblasts metabolic activity, exhibiting a high degree of cytotoxicity at all measured time points. At 0.1% and 1%, Duraphat and Fixofluor or Fluor Protector S and Cervitec F exerted the lowest or highest cytotoxic effects, respectively. Similar effects were evidenced when induction of apoptosis/necrosis and cell migration assays were analyzed. Immunocytochemical assays revealed a similar number of fibroblasts, without changes in the morphology and F-actin content at 0.1% concentration of all tested materials, while at 1% concentration, Fluor Protector S and Cervitec F showed few cells with aberrant morphology or non-adhered cells, respectively.Different commercial topical fluoride varnishes with the same therapeutic indication may exhibit different biological effects and cytotoxicity on fibroblasts.CONCLUSIONSDifferent commercial topical fluoride varnishes with the same therapeutic indication may exhibit different biological effects and cytotoxicity on fibroblasts. To compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human fibroblasts: Cervitec F, Fixofluor, Fluor Protector S and Duraphat. Human gingival fibroblasts (hGF) were exposed to different concentrations of fluoride varnishes extracts. Biological assays, including MTT and IC50 value determination, annexin-V/7-AAD staining, cell migration and F-actin staining with phalloidin were carried out. Statistical analyses were performed using one-way ANOVA and Tukey's post hoc test. At 4% concentration, all of the fluoride varnishes extracts affected fibroblasts metabolic activity, exhibiting a high degree of cytotoxicity at all measured time points. At 0.1% and 1%, Duraphat and Fixofluor or Fluor Protector S and Cervitec F exerted the lowest or highest cytotoxic effects, respectively. Similar effects were evidenced when induction of apoptosis/necrosis and cell migration assays were analyzed. Immunocytochemical assays revealed a similar number of fibroblasts, without changes in the morphology and F-actin content at 0.1% concentration of all tested materials, while at 1% concentration, Fluor Protector S and Cervitec F showed few cells with aberrant morphology or non-adhered cells, respectively. Different commercial topical fluoride varnishes with the same therapeutic indication may exhibit different biological effects and cytotoxicity on fibroblasts. •Different fluoride varnishes exhibit different biological effects and cytotoxicity on human gingival fibroblasts.•hGFs show better biocompatibility after exposition to Fixofluor and Duraphat.•In vitro investigations are required in order to compare the fluoride varnishes biological properties. To compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human fibroblasts: Cervitec F, Fixofluor, Fluor Protector S and Duraphat. Human gingival fibroblasts (hGF) were exposed to different concentrations of fluoride varnishes extracts. Biological assays, including MTT and IC50 value determination, annexin-V/7-AAD staining, cell migration and F-actin staining with phalloidin were carried out. Statistical analyses were performed using one-way ANOVA and Tukey’s post hoc test. At 4% concentration, all of the fluoride varnishes extracts affected fibroblasts metabolic activity, exhibiting a high degree of cytotoxicity at all measured time points. At 0.1% and 1%, Duraphat and Fixofluor or Fluor Protector S and Cervitec F exerted the lowest or highest cytotoxic effects, respectively. Similar effects were evidenced when induction of apoptosis/necrosis and cell migration assays were analyzed. Immunocytochemical assays revealed a similar number of fibroblasts, without changes in the morphology and F-actin content at 0.1% concentration of all tested materials, while at 1% concentration, Fluor Protector S and Cervitec F showed few cells with aberrant morphology or non-adhered cells, respectively. Different commercial topical fluoride varnishes with the same therapeutic indication may exhibit different biological effects and cytotoxicity on fibroblasts. |
| ArticleNumber | 151723 |
| Author | Pecci-Lloret, Miguel R. López-García, Sergio García-Bernal, David Rodríguez-Lozano, Francisco J. Pecci-Lloret, María P. Guerrero-Gironés, Julia |
| Author_xml | – sequence: 1 givenname: Sergio surname: López-García fullname: López-García, Sergio organization: Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute of Murcia, Clinical University Hospital Virgen de la Arrixaca, University of Murcia, 30120 Murcia, Spain – sequence: 2 givenname: María P. surname: Pecci-Lloret fullname: Pecci-Lloret, María P. organization: Gerodontology and Special Care Dentistry Unit, Hospital Morales Meseguer, Medicine School, University of Murcia, 30100 Murcia, Spain – sequence: 3 givenname: Miguel R. orcidid: 0000-0002-8579-6903 surname: Pecci-Lloret fullname: Pecci-Lloret, Miguel R. organization: Gerodontology and Special Care Dentistry Unit, Hospital Morales Meseguer, Medicine School, University of Murcia, 30100 Murcia, Spain – sequence: 4 givenname: Julia surname: Guerrero-Gironés fullname: Guerrero-Gironés, Julia email: julia.guerrero@um.es organization: Gerodontology and Special Care Dentistry Unit, Hospital Morales Meseguer, Medicine School, University of Murcia, 30100 Murcia, Spain – sequence: 5 givenname: Francisco J. surname: Rodríguez-Lozano fullname: Rodríguez-Lozano, Francisco J. organization: Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute of Murcia, Clinical University Hospital Virgen de la Arrixaca, University of Murcia, 30120 Murcia, Spain – sequence: 6 givenname: David surname: García-Bernal fullname: García-Bernal, David organization: Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute of Murcia, Clinical University Hospital Virgen de la Arrixaca, University of Murcia, 30120 Murcia, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33857632$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_ijerph19052954 crossref_primary_10_1016_j_aanat_2022_151949 crossref_primary_10_1159_000540119 crossref_primary_10_3390_pharmaceutics14112415 crossref_primary_10_1016_j_aanat_2021_151829 crossref_primary_10_1016_j_sdentj_2024_02_005 crossref_primary_10_3390_toxics13030195 crossref_primary_10_1111_jopr_13980 crossref_primary_10_1016_j_aanat_2022_152026 crossref_primary_10_1016_j_dental_2024_07_012 crossref_primary_10_3390_ma15062104 crossref_primary_10_1016_j_prosdent_2022_01_025 |
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| Snippet | •Different fluoride varnishes exhibit different biological effects and cytotoxicity on human gingival fibroblasts.•hGFs show better biocompatibility after... To compare the in vitro cytotoxicity of four commercial topical fluoride varnishes widely used in daily dental practice for the prevention of caries on human... |
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| SubjectTerms | Biological effects Cytotoxicity Fluoride varnishes Gingival cells |
| Title | Topical fluoride varnishes promote several biological responses on human gingival cells |
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