Hepatitis B e antigen and antibody activity in hepatitis B virus infection
Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three ye...
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| Published in | The Journal of pediatrics Vol. 91; no. 4; pp. 540 - 544 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Mosby, Inc
01.10.1977
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3476 1097-6833 |
| DOI | 10.1016/S0022-3476(77)80498-8 |
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| Abstract | Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HB
eAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HB
eAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HB
e activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HB
sAg positive subjects with anti HB
e did not eventually become seronegative for HB
sAg. |
|---|---|
| AbstractList | Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HB
eAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HB
eAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HB
e activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HB
sAg positive subjects with anti HB
e did not eventually become seronegative for HB
sAg. Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HBeAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HBeAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HBe activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HBsAg positive subjects with anti HBe did not eventually become seronegative for HBsAg. Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HBeAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HBeAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HBe activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HBsAg positive subjects with anti HBe did not eventually become seronegative for HBsAg.Groups of institutionalized subjects, volunteer blood donors with serologic evidence of asymptomatic hepatitis B virus infection, and patients with acute type B viral hepatitis were studied for the presence of hepatitis B e antigen and antibody in a sequential manner over a period of two to three years. HBeAg was detected in 9.5% of institutionalized residents and volunteer blood donors and in 24% of patients with acute type B viral hepatitis. HBeAg positive subjects frequently had persistently elevated pyruvic glutamic transaminase levels in the serum. Anti HBe activity was observed in 26 to 32% of subjects positive for hepatitis B surface antigen. Long-term follow-up indicated that HBsAg positive subjects with anti HBe did not eventually become seronegative for HBsAg. |
| Author | Ogra, P.L. Makhdoomi, G.M. Nath, N. Tiku, M.L. Beutner, K.R. |
| Author_xml | – sequence: 1 givenname: M.L. surname: Tiku fullname: Tiku, M.L. organization: Department of Pediatrics,State University of New York at Buffalo, Buffalo, N.Y. USA – sequence: 2 givenname: G.M. surname: Makhdoomi fullname: Makhdoomi, G.M. organization: Department of Pediatrics,State University of New York at Buffalo, Buffalo, N.Y. USA – sequence: 3 givenname: K.R. surname: Beutner fullname: Beutner, K.R. organization: Department of Pediatrics,State University of New York at Buffalo, Buffalo, N.Y. USA – sequence: 4 givenname: N. surname: Nath fullname: Nath, N. organization: Department of Pediatrics,State University of New York at Buffalo, Buffalo, N.Y. USA – sequence: 5 givenname: P.L. surname: Ogra fullname: Ogra, P.L. organization: Department of Pediatrics,State University of New York at Buffalo, Buffalo, N.Y. USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/908972$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0016-5085(76)80188-6 10.1056/NEJM197604012941411 10.1001/jama.1975.03240160020020 10.1128/JVI.12.5.995-1005.1973 10.1016/S0140-6736(74)91127-1 10.1016/S0140-6736(75)92658-6 10.4049/jimmunol.117.1.102 10.1128/IAI.14.3.631-635.1976 10.1136/bmj.4.5991.252 10.1016/S0016-5085(76)80364-2 10.1093/infdis/134.1.85 10.1056/NEJM197406132902402 10.1016/S0140-6736(75)92657-4 10.1056/NEJM197604012941402 10.1056/NEJM197610212951701 10.7326/0003-4819-85-4-458 10.4049/jimmunol.109.4.834 10.1126/science.170.3955.332 |
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| References_xml | – volume: 290 start-page: 1336 year: 1974 ident: bib1 article-title: Antibody to hepatitis B core antigen: A sensitive indicator of hepatitis B virus replication publication-title: N Engl J Med – volume: 71 start-page: 208 year: 1976 ident: bib10 article-title: Studies of the “e” antigen in acute and chronic hepatitis publication-title: Gastroenterology – volume: 14 start-page: 631 year: 1976 ident: bib13 article-title: Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system publication-title: Infect Immun – volume: 134 start-page: 85 year: 1976 ident: bib16 article-title: Dane particle associated DNA polymerase and e antigen: Relation to chronic hepatitis among carriers of hepatitis B surface antigen publication-title: J Infect Dis – volume: 294 start-page: 746 year: 1976 ident: bib6 article-title: e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to theirinfants publication-title: N Engl J Med – volume: 71 start-page: 804 year: 1976 ident: bib15 article-title: Detection of e antigen and antibody: Correlations with hepatitis B surface and hepatitis B core antigens, liver disease, and outcome in hepatitis Binfections publication-title: Gastroenterology – year: April 11–16, 1976 ident: bib3 article-title: Nonspecific test reactions for antibodies to hepatitis B surface antigen in chronic HB publication-title: presented at 60th Annual Meeting of Federation of American Societies for Experimental Biology – volume: 294 start-page: 779 year: 1976 ident: bib17 article-title: e: A third hepatitis B antigen? 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| SubjectTerms | Adolescent Adult Aged Alanine Transaminase - blood Antibodies, Viral - analysis Carrier State Child Child, Preschool DNA-Directed DNA Polymerase - blood Hepatitis B - enzymology Hepatitis B - immunology Hepatitis B Antibodies - analysis Hepatitis B Antigens - analysis Hepatitis B Core Antigens - analysis Hepatitis B Surface Antigens - analysis Hepatitis B virus - immunology Humans Middle Aged |
| Title | Hepatitis B e antigen and antibody activity in hepatitis B virus infection |
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