Clinical relevance of brain atrophy subtypes categorization in memory clinics

Introduction The clinical relevance of brain atrophy subtypes categorization in non‐demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. Methods A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairm...

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Published inAlzheimer's & dementia Vol. 17; no. 4; pp. 641 - 652
Main Authors Planche, Vincent, Bouteloup, Vincent, Mangin, Jean‐François, Dubois, Bruno, Delrieu, Julien, Pasquier, Florence, Blanc, Frédéric, Paquet, Claire, Hanon, Olivier, Gabelle, Audrey, Ceccaldi, Matthieu, Annweiler, Cédric, Krolak‐Salmon, Pierre, Habert, Marie‐Odile, Fischer, Clara, Chupin, Marie, Béjot, Yannick, Godefroy, Olivier, Wallon, David, Sauvée, Mathilde, Bourdel‐Marchasson, Isabelle, Jalenques, Isabelle, Tison, François, Chêne, Geneviève, Dufouil, Carole
Format Journal Article
LanguageEnglish
Published United States Alzheimer's Association / Wiley 01.04.2021
Subjects
Aged
Alzheimer disease
Alzheimer Disease / classification
Alzheimer Disease / pathology
Ambulatory Care Facilities
Atrophy / pathology
Brain / pathology
brain atrophy subtypes
Cohort Studies
dementia
Female
hippocampus
Hippocampus / pathology
Humans
Life Sciences
Magnetic Resonance Imaging
Male
Memory Disorders / classification
MRI
Santé publique et épidémiologie
dementia
hippocampus
brain atrophy subtypes
Alzheimer disease
MRI
Online AccessGet full text
ISSN1552-5260
1552-5279
1552-5279
DOI10.1002/alz.12231

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Abstract Introduction The clinical relevance of brain atrophy subtypes categorization in non‐demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. Methods A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms. Results Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid‐positive participants. Hippocampal‐sparing and limbic‐predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal‐sparing and minimal/no atrophy groups. Discussion Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
AbstractList The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown.INTRODUCTIONThe clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown.A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms.METHODSA total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms.Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups.RESULTSTypical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups.Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.DISCUSSIONAtrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms. Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups. Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
Introduction: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown.Methods: A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms.Results: Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups.Discussion: Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
Introduction The clinical relevance of brain atrophy subtypes categorization in non‐demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown. Methods A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms. Results Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid‐positive participants. Hippocampal‐sparing and limbic‐predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal‐sparing and minimal/no atrophy groups. Discussion Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
Author Mangin, Jean‐François
Béjot, Yannick
Dufouil, Carole
Chupin, Marie
Dubois, Bruno
Delrieu, Julien
Ceccaldi, Matthieu
Krolak‐Salmon, Pierre
Chêne, Geneviève
Gabelle, Audrey
Godefroy, Olivier
Tison, François
Habert, Marie‐Odile
Bouteloup, Vincent
Planche, Vincent
Wallon, David
Pasquier, Florence
Jalenques, Isabelle
Blanc, Frédéric
Sauvée, Mathilde
Paquet, Claire
Hanon, Olivier
Bourdel‐Marchasson, Isabelle
Fischer, Clara
Annweiler, Cédric
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Keywords dementia
hippocampus
brain atrophy subtypes
Alzheimer disease
MRI
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Snippet Introduction The clinical relevance of brain atrophy subtypes categorization in non‐demented persons without a priori knowledge regarding their amyloid status...
The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical...
Introduction: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status...
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SubjectTerms Aged
Alzheimer disease
Alzheimer Disease / classification
Alzheimer Disease / pathology
Ambulatory Care Facilities
Atrophy / pathology
Brain / pathology
brain atrophy subtypes
Cohort Studies
dementia
Female
hippocampus
Hippocampus / pathology
Humans
Life Sciences
Magnetic Resonance Imaging
Male
Memory Disorders / classification
MRI
Santé publique et épidémiologie
Title Clinical relevance of brain atrophy subtypes categorization in memory clinics
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.12231
https://www.ncbi.nlm.nih.gov/pubmed/33325121
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Volume 17
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