Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacterium tuberculosis

Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) me...

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Published inEuropean journal of medicinal chemistry Vol. 70; pp. 589 - 593
Main Authors Hoffman, Amanda E., DeStefano, Michelle, Shoen, Carolyn, Gopinath, Krishnamoorthy, Warner, Digby F., Cynamon, Michael, Doyle, Robert P.
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.12.2013
Subjects
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteriocidal
Cobalt
Cobalt - chemistry
Copper
Copper - chemistry
Diphosphates - chemistry
Dose-Response Relationship, Drug
MDR-TB
Microbial Sensitivity Tests
Models, Molecular
Mycobacterium - drug effects
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Pyrophosphate
Structure-Activity Relationship
INH
Bacteriocidal
MOTT
MIC
Pyrophosphate
MDR-TB
XDR-TB
Copper
Cobalt
TB
isoniazid
tuberculosis
extensively drug-resistant TB
multidrug-resistant TB
Mycobacteria other than TB
minimum inhibitory concentration
Online AccessGet full text
ISSN0223-5234
1768-3254
1768-3254
DOI10.1016/j.ejmech.2013.10.044

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Abstract Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacterium tuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis. [Display omitted] •Cobalt and copper pyrophosphate complexes have potency and selectivity against TB.•Cobalt is more effective than copper with lower Human lung cell toxicity.•Resistance, even at 2× MIC, is not observed in wild-type TB or a TB transposon library.
AbstractList Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacterium tuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis.Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacterium tuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis.
Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacterium tuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis.
Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacterium tuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis. [Display omitted] •Cobalt and copper pyrophosphate complexes have potency and selectivity against TB.•Cobalt is more effective than copper with lower Human lung cell toxicity.•Resistance, even at 2× MIC, is not observed in wild-type TB or a TB transposon library.
Author Gopinath, Krishnamoorthy
Shoen, Carolyn
Hoffman, Amanda E.
Doyle, Robert P.
DeStefano, Michelle
Warner, Digby F.
Cynamon, Michael
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  givenname: Robert P.
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Cites_doi 10.1002/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y
10.1016/0162-0134(96)00015-3
10.1016/j.mib.2004.08.011
10.1039/c2cc31023f
10.1016/j.ccr.2006.11.017
10.1039/c1mt00107h
10.1073/pnas.1009261108
10.1021/jm201041d
10.1107/S1600536804008323
10.1016/j.bmc.2007.01.030
10.1039/c0md00266f
10.1021/bi201418k
10.1183/09031936.00042607
10.1016/j.ejmech.2009.12.053
10.3201/eid1303.061400
10.1186/1471-2180-11-35
10.1016/j.drudis.2009.09.003
10.1128/AAC.49.5.2008-2014.2005
10.1038/35016103
10.1186/1471-2458-8-266
10.1016/S0140-6736(06)69863-2
10.2174/156802611795429158
10.1128/AAC.00106-09
10.1002/ejic.200800196
10.1074/jbc.M901581200
10.1016/j.saa.2011.03.032
10.1038/nature09657
10.1039/c2dt30322a
10.1128/AAC.37.11.2344
10.1016/S0140-6736(09)60331-7
10.1016/j.jhin.2007.10.009
10.1016/S0960-894X(00)00058-5
10.1126/science.257.5073.1055
10.1021/ic1006007
10.1073/pnas.091096998
10.1021/ja109665t
10.1016/j.addr.2012.01.007
10.1126/science.1184785
10.1016/S0960-894X(00)00648-X
10.1038/nchembio.109
10.2741/1454
10.1126/science.328.5980.841
10.1111/j.1365-3156.2010.02581.x
10.2217/fmb.09.20
10.1016/j.jinorgbio.2009.07.010
10.1016/j.bmcl.2004.09.052
10.1039/C0DT01607A
10.1016/j.ccm.2009.08.015
10.1126/science.1171583
10.1016/S0140-6736(03)14918-5
10.1111/j.1432-1033.1994.tb18748.x
10.1038/nm0307-309
10.1107/S0108270107064803
10.1016/j.tube.2011.12.006
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Keywords INH
Bacteriocidal
MOTT
MIC
Pyrophosphate
MDR-TB
XDR-TB
Copper
Cobalt
TB
isoniazid
tuberculosis
extensively drug-resistant TB
multidrug-resistant TB
Mycobacteria other than TB
minimum inhibitory concentration
Language English
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References Bottari, Maccari, Monforte, Ottana, Rotondo, Vigorita (bib46) 2000; 10
Barry (bib17) 2011; 11
Mehtar, Wiid, Todorov (bib42) 2008; 68
Zoroddu, Zanetti, Pogni, Basosi (bib49) 1996; 63
Rodrigues, Ramos, Couto, Amaral, Viveiros (bib43) 2011; 11
Ginsberg, Laurenzi, Rouse, Whitney, Spigelman (bib21) 2009; 53
Prisecaru, Devereux, Barron, McCann, Colleran, Casey, McKeee, Kellett (bib53) 2012; 48
Harper (bib22) 2007; 13
Agranoff, Krishna (bib58) 2004; 9
Aziz, Wright, Laszlo, De Muynck, Portaels, Van Deun, Wells, Nunn, Blanc, Raviglione (bib10) 2006; 368
Datiko, Yassin, Chekol, Kabeto, Lindtjorn (bib6) 2008; 8
Migliori, Dheda, Centis, Mwaba, Bates, O'Grady, Hoelscher, Zumla (bib5) 2010; 15
Duncan, Barry (bib20) 2004; 7
Shah, Wright, Bai, Barrera, Boulahbal, Martin-Casabona, Drobniewski, Gilpin, Havelkova, Lepe, Lumb, Metchock, Portaels, Rodrigues, Rusch-Gerdes, Van Deun, Vincent, Laserson, Wells, Cegielski (bib19) 2007; 13
Holtz, Cegielski (bib13) 2007; 30
Rubin-Preminger, Kozlov, Goldberg (bib38) 2008; 64
Kellett, O'Connor, McCann, McNamara, Lynch, Rosair, McKee, Creaven, Walsh, McClean, Foltyn, O'Shea, Howe, Devereux (bib51) 2011; 40
Hu, Sharma, Qin, Gao, Cross (bib56) 2009; 284
Cox, Hargreaves, Ismailov (bib12) 2003; 362
Miller, Walz, Zhu, Wu, Moraski, Mollmann, Tristani, Crumbliss, Ferdig, Checkley, Edwards, Boshoff (bib8) 2011; 133
van Rijt, Sadler (bib28) 2009; 14
Stover, Warrener, VanDevanter, Sherman, Arain, Langhorne, Anderson, Towell, Yuan, McMurray, Kreiswirth, Barry, Baker (bib25) 2000; 405
Marino, Vortherms, Hoffman, Doyle (bib34) 2010; 49
Kappe, Vaughan, Boddey, Cowman (bib7) 2010; 328
Lu, Qin, Yang, Zhu (bib39) 2004; 60
Guo, Sadler (bib26) 1999; 38
Riccardi, Pasca, Buroni (bib11) 2009; 4
Migliori, D'Arcy Richardson, Sotgiu, Lange (bib14) 2009; 30
Makarov, Manina, Mikusova, Mollmann, Ryabova, Saint-Joanis, Dhar, Pasca, Buroni, Lucarelli, Milano, De Rossi, Belanova, Bobovska, Dianiskova, Kordulakova, Sala, Fullam, Schneider, McKinney, Brodin, Christophe, Waddell, Butcher, Albrethsen, Rosenkrands, Brosch, Nandi, Bharath, Gaonkar, Shandil, Balasubramanian, Balganesh, Tyagi, Grosset, Riccardi, Cole (bib24) 2009; 324
Arguello, Gonzalez-Guerrero, Raimunda (bib57) 2011; 50
Spoelstra, Westerhoff, Pinedo, Dekker, Lankelma (bib44) 1994; 221
Nunn, Williams, Floyd, Dye, Elzinga, Raviglione (bib9) 2005; 5
O'Connor, Kellett, McCann, Rosair, McNamara, Howe, Creaven, McClean, Kia, O'Shea, Devereux (bib52) 2012; 55
Koul, Arnoult, Lounis, Guillemont, Andries (bib23) 2011; 469
Hurtley, Ash, Roberts (bib1) 2010; 328
Klemens, DeStefano, Cynamon (bib37) 1993; 37
Ikotun, Ouellette, Lloret, Kruger, Julve, Doyle (bib33) 2008
Melnic, Prodius, Stoeckli-Evans, Shova, Turta (bib54) 2010; 45
Pablos-Mendez, Raviglione, Laszlo, Binkin, Rieder, Bustreo, Cohn, Lambregts-van Weezenbeek, Kim, Chaulet, Nunn (bib15) 1998; 338
Wolschendorf, Ackart, Shrestha, Hascall-Dove, Nolan, Lamichhane, Wang, Bossmann, Basaraba, Niederweis (bib41) 2011; 108
Malik, Lu, Zhao, Singh, Hattan, Domagala, Kerns, Drlica (bib40) 2005; 49
Maccari, Ottana, Bottari, Rotondo, Vigorita (bib48) 2004; 14
Wright, Zignol, Van Deun, Falzon, Gerdes, Feldman, Hoffner, Drobniewski, Barrera, van Soolingen, Boulabhal, Paramasivan, Kam, Mitarai, Nunn, Raviglione (bib16) 2009; 373
Gold, Deng, Bryk, Vargas, Eliezer, Roberts, Jiang, Nathan (bib35) 2008; 4
Manca, Tsenova, Bergtold, Freeman, Tovey, Musser, Barry, Freedman, Kaplan (bib36) 2001; 98
Jamadar, Duhme-Klair, Vemuri, Sritharan, Dandawate, Padhye (bib30) 2012; 41
Caminero (bib18) 2008; 12
Bottari, Maccari, Monforte, Ottana, Rotondo, Vigorita (bib47) 2001; 11
Kellett, O'Connor, McCann, Howe, Casey, McCarron, Kavanagh, McNamara, Kennedy, May, Skell, O'Shea, Devereux (bib50) 2011; 2
Janin (bib4) 2007; 15
Ronconi, Sadler (bib27) 2007; 251
Dupont, Grass, Rensing (bib45) 2011; 3
Poehlsgaard, Douthwaite (bib2) 2005; 3
Ikotun, Higbee, Ouellette, Doyle (bib32) 2009; 103
Graf, Lippard (bib29) 2012; 64
Bloom, Murray (bib3) 1992; 257
Rowland, Niederweis (bib55) 2012; 92
Kharadi (bib31) 2011; 79
Makarov (10.1016/j.ejmech.2013.10.044_bib24) 2009; 324
Kellett (10.1016/j.ejmech.2013.10.044_bib50) 2011; 2
Duncan (10.1016/j.ejmech.2013.10.044_bib20) 2004; 7
Migliori (10.1016/j.ejmech.2013.10.044_bib5) 2010; 15
Miller (10.1016/j.ejmech.2013.10.044_bib8) 2011; 133
Guo (10.1016/j.ejmech.2013.10.044_bib26) 1999; 38
Hu (10.1016/j.ejmech.2013.10.044_bib56) 2009; 284
Malik (10.1016/j.ejmech.2013.10.044_bib40) 2005; 49
O'Connor (10.1016/j.ejmech.2013.10.044_bib52) 2012; 55
Wright (10.1016/j.ejmech.2013.10.044_bib16) 2009; 373
Dupont (10.1016/j.ejmech.2013.10.044_bib45) 2011; 3
Klemens (10.1016/j.ejmech.2013.10.044_bib37) 1993; 37
Aziz (10.1016/j.ejmech.2013.10.044_bib10) 2006; 368
Poehlsgaard (10.1016/j.ejmech.2013.10.044_bib2) 2005; 3
Stover (10.1016/j.ejmech.2013.10.044_bib25) 2000; 405
Rubin-Preminger (10.1016/j.ejmech.2013.10.044_bib38) 2008; 64
Kellett (10.1016/j.ejmech.2013.10.044_bib51) 2011; 40
Rowland (10.1016/j.ejmech.2013.10.044_bib55) 2012; 92
Riccardi (10.1016/j.ejmech.2013.10.044_bib11) 2009; 4
Bottari (10.1016/j.ejmech.2013.10.044_bib46) 2000; 10
Gold (10.1016/j.ejmech.2013.10.044_bib35) 2008; 4
Kappe (10.1016/j.ejmech.2013.10.044_bib7) 2010; 328
Cox (10.1016/j.ejmech.2013.10.044_bib12) 2003; 362
Mehtar (10.1016/j.ejmech.2013.10.044_bib42) 2008; 68
Marino (10.1016/j.ejmech.2013.10.044_bib34) 2010; 49
Hurtley (10.1016/j.ejmech.2013.10.044_bib1) 2010; 328
Ikotun (10.1016/j.ejmech.2013.10.044_bib32) 2009; 103
Datiko (10.1016/j.ejmech.2013.10.044_bib6) 2008; 8
Barry (10.1016/j.ejmech.2013.10.044_bib17) 2011; 11
Koul (10.1016/j.ejmech.2013.10.044_bib23) 2011; 469
Kharadi (10.1016/j.ejmech.2013.10.044_bib31) 2011; 79
Graf (10.1016/j.ejmech.2013.10.044_bib29) 2012; 64
Arguello (10.1016/j.ejmech.2013.10.044_bib57) 2011; 50
Bloom (10.1016/j.ejmech.2013.10.044_bib3) 1992; 257
van Rijt (10.1016/j.ejmech.2013.10.044_bib28) 2009; 14
Janin (10.1016/j.ejmech.2013.10.044_bib4) 2007; 15
Lu (10.1016/j.ejmech.2013.10.044_bib39) 2004; 60
Prisecaru (10.1016/j.ejmech.2013.10.044_bib53) 2012; 48
Ginsberg (10.1016/j.ejmech.2013.10.044_bib21) 2009; 53
Shah (10.1016/j.ejmech.2013.10.044_bib19) 2007; 13
Agranoff (10.1016/j.ejmech.2013.10.044_bib58) 2004; 9
Migliori (10.1016/j.ejmech.2013.10.044_bib14) 2009; 30
Ikotun (10.1016/j.ejmech.2013.10.044_bib33) 2008
Holtz (10.1016/j.ejmech.2013.10.044_bib13) 2007; 30
Rodrigues (10.1016/j.ejmech.2013.10.044_bib43) 2011; 11
Bottari (10.1016/j.ejmech.2013.10.044_bib47) 2001; 11
Zoroddu (10.1016/j.ejmech.2013.10.044_bib49) 1996; 63
Wolschendorf (10.1016/j.ejmech.2013.10.044_bib41) 2011; 108
Nunn (10.1016/j.ejmech.2013.10.044_bib9) 2005; 5
Manca (10.1016/j.ejmech.2013.10.044_bib36) 2001; 98
Jamadar (10.1016/j.ejmech.2013.10.044_bib30) 2012; 41
Caminero (10.1016/j.ejmech.2013.10.044_bib18) 2008; 12
Melnic (10.1016/j.ejmech.2013.10.044_bib54) 2010; 45
Maccari (10.1016/j.ejmech.2013.10.044_bib48) 2004; 14
Ronconi (10.1016/j.ejmech.2013.10.044_bib27) 2007; 251
Harper (10.1016/j.ejmech.2013.10.044_bib22) 2007; 13
Pablos-Mendez (10.1016/j.ejmech.2013.10.044_bib15) 1998; 338
Spoelstra (10.1016/j.ejmech.2013.10.044_bib44) 1994; 221
References_xml – volume: 68
  start-page: 45
  year: 2008
  end-page: 51
  ident: bib42
  article-title: The antimicrobial activity of copper and copper alloys against nosocomial pathogens and
  publication-title: J. Hosp. Infect.
– volume: 2
  start-page: 579
  year: 2011
  end-page: 584
  ident: bib50
  article-title: Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
  publication-title: Medchemcomm
– volume: 14
  start-page: 5731
  year: 2004
  end-page: 5733
  ident: bib48
  article-title: In vitro advanced antimycobacterial screening of cobalt(II) and copper(II) complexes of fluorinated isonicotinoylhydrazones
  publication-title: Bioorg. Med. Chem. Lett.
– volume: 469
  start-page: 483
  year: 2011
  end-page: 490
  ident: bib23
  article-title: The challenge of new drug discovery for tuberculosis
  publication-title: Nature
– volume: 50
  start-page: 9940
  year: 2011
  end-page: 9949
  ident: bib57
  article-title: Bacterial transition metal P(1B)-ATPases: transport mechanism and roles in virulence
  publication-title: Biochemistry
– volume: 8
  start-page: 266
  year: 2008
  ident: bib6
  article-title: The rate of TB-HIV co-infection depends on the prevalence of HIV infection in a community
  publication-title: BMC Public Health
– volume: 14
  start-page: 1089
  year: 2009
  end-page: 1097
  ident: bib28
  article-title: Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
  publication-title: Drug Discov. Today
– volume: 221
  start-page: 363
  year: 1994
  end-page: 373
  ident: bib44
  article-title: The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate
  publication-title: Eur. J. Biochem.
– volume: 79
  start-page: 898
  year: 2011
  end-page: 903
  ident: bib31
  article-title: Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin
  publication-title: Spectrochim. Acta. Part A
– volume: 284
  start-page: 15619
  year: 2009
  end-page: 15628
  ident: bib56
  article-title: Ligand binding in the conserved interhelical loop of CorA, a magnesium transporter from
  publication-title: J. Biol. Chem.
– volume: 338
  start-page: 1641
  year: 1998
  end-page: 1649
  ident: bib15
  article-title: Global surveillance for antituberculosis-drug resistance, 1994–1997. World Health Organization-International Union against tuberculosis and lung disease working group on anti-tuberculosis drug resistance surveillance
  publication-title: New Engl. J. Med.
– volume: 108
  start-page: 1621
  year: 2011
  end-page: 1626
  ident: bib41
  article-title: Copper resistance is essential for virulence of
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 64
  start-page: M83
  year: 2008
  end-page: M86
  ident: bib38
  article-title: Hydrogen-bonding and pi-pi stacking interactions in apuachloridobis(1,10-phenanthroline)cobalt(II) chloride dichloridobis(1,10-phenanthroline)cobalt(II) hexahydrate
  publication-title: Acta Crystallogr. C
– volume: 30
  start-page: 396
  year: 2007
  ident: bib13
  article-title: Origin of the term XDR-TB
  publication-title: Eur. Respir. J.
– volume: 4
  start-page: 609
  year: 2008
  end-page: 616
  ident: bib35
  article-title: Identification of a copper-binding metallothionein in pathogenic mycobacteria
  publication-title: Nat. Chem. Biol.
– volume: 53
  start-page: 3720
  year: 2009
  end-page: 3725
  ident: bib21
  article-title: Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects
  publication-title: Antimicrob. Agents Chemother.
– volume: 45
  start-page: 1465
  year: 2010
  end-page: 1469
  ident: bib54
  article-title: Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates
  publication-title: Eur. J. Med. Chem.
– volume: 328
  start-page: 862
  year: 2010
  end-page: 866
  ident: bib7
  article-title: That was then but this is now: malaria research in the time of an eradication agenda
  publication-title: Science
– volume: 11
  year: 2011
  ident: bib43
  article-title: Ethidium bromide transport across
  publication-title: BMC Microbiol.
– volume: 55
  start-page: 1957
  year: 2012
  end-page: 1968
  ident: bib52
  article-title: Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines
  publication-title: J. Med. Chem.
– volume: 49
  start-page: 6790
  year: 2010
  end-page: 6792
  ident: bib34
  article-title: Expanding monomeric pyrophosphate complexes beyond platinum
  publication-title: Inorg. Chem.
– volume: 9
  start-page: 2996
  year: 2004
  end-page: 3006
  ident: bib58
  article-title: Metal ion transport and regulation in
  publication-title: Front. Biosci. J. Virtual Libr.
– volume: 4
  start-page: 597
  year: 2009
  end-page: 614
  ident: bib11
  article-title: Mycobacterium tuberculosis: drug resistance and future perspectives
  publication-title: Future Microbiol.
– volume: 405
  start-page: 962
  year: 2000
  end-page: 966
  ident: bib25
  article-title: A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
  publication-title: Nature
– volume: 103
  start-page: 1254
  year: 2009
  end-page: 1264
  ident: bib32
  article-title: Pyrophosphate-bridged complexes with picomolar toxicity
  publication-title: J. Inorg. Biochem.
– volume: 11
  start-page: 301
  year: 2001
  end-page: 303
  ident: bib47
  article-title: Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10
  publication-title: Bioorg. Med. Chem. Lett.
– volume: 373
  start-page: 1861
  year: 2009
  end-page: 1873
  ident: bib16
  article-title: Global project on anti-tuberculosis drug resistance, epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the global project on anti-tuberculosis drug resistance surveillance
  publication-title: Lancet
– volume: 10
  start-page: 657
  year: 2000
  end-page: 660
  ident: bib46
  article-title: Isoniazid-related copper(II) and nickel(II) complexes with antimycobacterial in vitro activity. Part 9
  publication-title: Bioorg. Med. Chem. Lett.
– volume: 40
  start-page: 1024
  year: 2011
  end-page: 1027
  ident: bib51
  article-title: Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties
  publication-title: Dalton Trans.
– volume: 30
  start-page: 637
  year: 2009
  end-page: 665
  ident: bib14
  article-title: Multidrug-resistant and extensively drug-resistant tuberculosis in the West. Europe and United States: epidemiology, surveillance, and control
  publication-title: Clin. Chest Med.
– volume: 11
  start-page: 1216
  year: 2011
  end-page: 1225
  ident: bib17
  article-title: Lessons from seven decades of antituberculosis drug discovery
  publication-title: Curr. Top. Med. Chem.
– volume: 64
  start-page: 993
  year: 2012
  end-page: 1004
  ident: bib29
  article-title: Redox activation of metal-based prodrugs as a strategy for drug delivery
  publication-title: Adv. Drug Delivery Rev.
– volume: 92
  start-page: 202
  year: 2012
  end-page: 210
  ident: bib55
  article-title: Resistance mechanisms of
  publication-title: Tuberculosis
– start-page: 2691
  year: 2008
  end-page: 2697
  ident: bib33
  article-title: Synthesis, structural, thermal and magnetic characterization of a pyrophosphato-bridged cobalt(II) complex
  publication-title: Eur. J. Inorg. Chem.
– volume: 5
  start-page: 819
  year: 2005
  end-page: 826
  ident: bib9
  article-title: Tuberculosis control in the era of HIV, nature reviews
  publication-title: Immunology
– volume: 3
  start-page: 1109
  year: 2011
  end-page: 1118
  ident: bib45
  article-title: Copper toxicity and the origin of bacterial resistance–new insights and applications
  publication-title: Metallomics: Integr. Biometal Sci.
– volume: 37
  start-page: 2344
  year: 1993
  end-page: 2347
  ident: bib37
  article-title: Therapy of multidrug-resistant tuberculosis: lessons from studies with mice
  publication-title: Antimicrob. Agents Chemother.
– volume: 41
  start-page: 9192
  year: 2012
  end-page: 9201
  ident: bib30
  article-title: Synthesis, characterisation and antitubercular activities of a series of pyruvate-containing aroylhydrazones and their Cu-complexes
  publication-title: Dalton Trans.
– volume: 257
  start-page: 1055
  year: 1992
  end-page: 1064
  ident: bib3
  article-title: Tuberculosis: commentary on a reemergent killer
  publication-title: Science
– volume: 48
  start-page: 6906
  year: 2012
  end-page: 6908
  ident: bib53
  article-title: Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu-2(mu-terephthalate)(1,10-phen)(4)](2+)
  publication-title: Chem. Commun.
– volume: 7
  start-page: 460
  year: 2004
  end-page: 465
  ident: bib20
  article-title: Prospects for new antitubercular drugs
  publication-title: Curr. Opin. Microbiol.
– volume: 133
  start-page: 2076
  year: 2011
  end-page: 2079
  ident: bib8
  article-title: Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria
  publication-title: J. Am. Chem. Soc.
– volume: 15
  start-page: 1052
  year: 2010
  end-page: 1066
  ident: bib5
  article-title: Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa
  publication-title: Trop. Med. Int. Health
– volume: 49
  start-page: 2008
  year: 2005
  end-page: 2014
  ident: bib40
  article-title: Lethality of quinolones against
  publication-title: Antimicrob. Agents Chemother.
– volume: 98
  start-page: 5752
  year: 2001
  end-page: 5757
  ident: bib36
  article-title: Virulence of a
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 60
  start-page: M574
  year: 2004
  end-page: M576
  ident: bib39
  article-title: Chlorobis(1,10-phenanthroline)copper(II) chloride methanol solvate 4.5-hydrate
  publication-title: Acta Crystallogr. E
– volume: 368
  start-page: 2142
  year: 2006
  end-page: 2154
  ident: bib10
  article-title: Epidemiology of antituberculosis drug resistance (the Global Project on Anti-Tuberculosis Drug Resistance Surveillance): an updated analysis
  publication-title: Lancet
– volume: 3
  start-page: 870
  year: 2005
  end-page: 881
  ident: bib2
  article-title: The bacterial ribosome as a target for antibiotics, nature reviews
  publication-title: Microbiology
– volume: 328
  start-page: 841
  year: 2010
  ident: bib1
  article-title: Tuberculosis & malaria. Landscapes of infection. Introduction
  publication-title: Science
– volume: 15
  start-page: 2479
  year: 2007
  end-page: 2513
  ident: bib4
  article-title: Antituberculosis drugs: ten years of research
  publication-title: Bioorg. Med. Chem.
– volume: 324
  start-page: 801
  year: 2009
  end-page: 804
  ident: bib24
  article-title: Benzothiazinones kill
  publication-title: Science
– volume: 13
  start-page: 380
  year: 2007
  end-page: 387
  ident: bib19
  article-title: Worldwide emergence of extensively drug-resistant tuberculosis
  publication-title: Emerging Infect. Dis.
– volume: 251
  start-page: 1633
  year: 2007
  end-page: 1648
  ident: bib27
  article-title: Using coordination chemistry to design new medicines
  publication-title: Coord. Chem. Rev.
– volume: 12
  start-page: 869
  year: 2008
  end-page: 877
  ident: bib18
  article-title: Likelihood of generating MDR-TB and XDR-TB under adequate national tuberculosis control programme implementation
  publication-title: Int. J. Tuberculosis Lung Dis.
– volume: 362
  start-page: 1858
  year: 2003
  end-page: 1859
  ident: bib12
  article-title: Effect of multidrug resistance on global tuberculosis control
  publication-title: Lancet
– volume: 63
  start-page: 291
  year: 1996
  end-page: 300
  ident: bib49
  article-title: An electron spin resonance study and antimicrobial activity of copper(II)-phenanthroline complexes
  publication-title: J. Inorg. Biochem.
– volume: 13
  start-page: 309
  year: 2007
  end-page: 312
  ident: bib22
  article-title: Tuberculosis, a neglected opportunity?
  publication-title: Nat. Med.
– volume: 38
  start-page: 1513
  year: 1999
  end-page: 1531
  ident: bib26
  article-title: Metals in medicine
  publication-title: Angew. Chem. Int. Ed.
– volume: 38
  start-page: 1513
  year: 1999
  ident: 10.1016/j.ejmech.2013.10.044_bib26
  article-title: Metals in medicine
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y
– volume: 63
  start-page: 291
  year: 1996
  ident: 10.1016/j.ejmech.2013.10.044_bib49
  article-title: An electron spin resonance study and antimicrobial activity of copper(II)-phenanthroline complexes
  publication-title: J. Inorg. Biochem.
  doi: 10.1016/0162-0134(96)00015-3
– volume: 7
  start-page: 460
  year: 2004
  ident: 10.1016/j.ejmech.2013.10.044_bib20
  article-title: Prospects for new antitubercular drugs
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2004.08.011
– volume: 48
  start-page: 6906
  year: 2012
  ident: 10.1016/j.ejmech.2013.10.044_bib53
  article-title: Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu-2(mu-terephthalate)(1,10-phen)(4)](2+)
  publication-title: Chem. Commun.
  doi: 10.1039/c2cc31023f
– volume: 251
  start-page: 1633
  year: 2007
  ident: 10.1016/j.ejmech.2013.10.044_bib27
  article-title: Using coordination chemistry to design new medicines
  publication-title: Coord. Chem. Rev.
  doi: 10.1016/j.ccr.2006.11.017
– volume: 3
  start-page: 1109
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib45
  article-title: Copper toxicity and the origin of bacterial resistance–new insights and applications
  publication-title: Metallomics: Integr. Biometal Sci.
  doi: 10.1039/c1mt00107h
– volume: 108
  start-page: 1621
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib41
  article-title: Copper resistance is essential for virulence of Mycobacterium tuberculosis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1009261108
– volume: 55
  start-page: 1957
  year: 2012
  ident: 10.1016/j.ejmech.2013.10.044_bib52
  publication-title: J. Med. Chem.
  doi: 10.1021/jm201041d
– volume: 60
  start-page: M574
  year: 2004
  ident: 10.1016/j.ejmech.2013.10.044_bib39
  article-title: Chlorobis(1,10-phenanthroline)copper(II) chloride methanol solvate 4.5-hydrate
  publication-title: Acta Crystallogr. E
  doi: 10.1107/S1600536804008323
– volume: 15
  start-page: 2479
  year: 2007
  ident: 10.1016/j.ejmech.2013.10.044_bib4
  article-title: Antituberculosis drugs: ten years of research
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2007.01.030
– volume: 5
  start-page: 819
  year: 2005
  ident: 10.1016/j.ejmech.2013.10.044_bib9
  article-title: Tuberculosis control in the era of HIV, nature reviews
  publication-title: Immunology
– volume: 2
  start-page: 579
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib50
  article-title: Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
  publication-title: Medchemcomm
  doi: 10.1039/c0md00266f
– volume: 50
  start-page: 9940
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib57
  article-title: Bacterial transition metal P(1B)-ATPases: transport mechanism and roles in virulence
  publication-title: Biochemistry
  doi: 10.1021/bi201418k
– volume: 3
  start-page: 870
  year: 2005
  ident: 10.1016/j.ejmech.2013.10.044_bib2
  article-title: The bacterial ribosome as a target for antibiotics, nature reviews
  publication-title: Microbiology
– volume: 30
  start-page: 396
  year: 2007
  ident: 10.1016/j.ejmech.2013.10.044_bib13
  article-title: Origin of the term XDR-TB
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00042607
– volume: 45
  start-page: 1465
  year: 2010
  ident: 10.1016/j.ejmech.2013.10.044_bib54
  article-title: Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2009.12.053
– volume: 13
  start-page: 380
  year: 2007
  ident: 10.1016/j.ejmech.2013.10.044_bib19
  article-title: Worldwide emergence of extensively drug-resistant tuberculosis
  publication-title: Emerging Infect. Dis.
  doi: 10.3201/eid1303.061400
– volume: 11
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib43
  article-title: Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance
  publication-title: BMC Microbiol.
  doi: 10.1186/1471-2180-11-35
– volume: 14
  start-page: 1089
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib28
  article-title: Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2009.09.003
– volume: 12
  start-page: 869
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib18
  article-title: Likelihood of generating MDR-TB and XDR-TB under adequate national tuberculosis control programme implementation
  publication-title: Int. J. Tuberculosis Lung Dis.
– volume: 49
  start-page: 2008
  year: 2005
  ident: 10.1016/j.ejmech.2013.10.044_bib40
  article-title: Lethality of quinolones against Mycobacterium smegmatis in the presence or absence of chloramphenicol
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.49.5.2008-2014.2005
– volume: 405
  start-page: 962
  year: 2000
  ident: 10.1016/j.ejmech.2013.10.044_bib25
  article-title: A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
  publication-title: Nature
  doi: 10.1038/35016103
– volume: 8
  start-page: 266
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib6
  article-title: The rate of TB-HIV co-infection depends on the prevalence of HIV infection in a community
  publication-title: BMC Public Health
  doi: 10.1186/1471-2458-8-266
– volume: 368
  start-page: 2142
  year: 2006
  ident: 10.1016/j.ejmech.2013.10.044_bib10
  article-title: Epidemiology of antituberculosis drug resistance (the Global Project on Anti-Tuberculosis Drug Resistance Surveillance): an updated analysis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)69863-2
– volume: 11
  start-page: 1216
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib17
  article-title: Lessons from seven decades of antituberculosis drug discovery
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/156802611795429158
– volume: 53
  start-page: 3720
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib21
  article-title: Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00106-09
– start-page: 2691
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib33
  article-title: Synthesis, structural, thermal and magnetic characterization of a pyrophosphato-bridged cobalt(II) complex
  publication-title: Eur. J. Inorg. Chem.
  doi: 10.1002/ejic.200800196
– volume: 284
  start-page: 15619
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib56
  article-title: Ligand binding in the conserved interhelical loop of CorA, a magnesium transporter from Mycobacterium tuberculosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M901581200
– volume: 338
  start-page: 1641
  year: 1998
  ident: 10.1016/j.ejmech.2013.10.044_bib15
  article-title: Global surveillance for antituberculosis-drug resistance, 1994–1997. World Health Organization-International Union against tuberculosis and lung disease working group on anti-tuberculosis drug resistance surveillance
  publication-title: New Engl. J. Med.
– volume: 79
  start-page: 898
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib31
  article-title: Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin
  publication-title: Spectrochim. Acta. Part A
  doi: 10.1016/j.saa.2011.03.032
– volume: 469
  start-page: 483
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib23
  article-title: The challenge of new drug discovery for tuberculosis
  publication-title: Nature
  doi: 10.1038/nature09657
– volume: 41
  start-page: 9192
  year: 2012
  ident: 10.1016/j.ejmech.2013.10.044_bib30
  article-title: Synthesis, characterisation and antitubercular activities of a series of pyruvate-containing aroylhydrazones and their Cu-complexes
  publication-title: Dalton Trans.
  doi: 10.1039/c2dt30322a
– volume: 37
  start-page: 2344
  year: 1993
  ident: 10.1016/j.ejmech.2013.10.044_bib37
  article-title: Therapy of multidrug-resistant tuberculosis: lessons from studies with mice
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.37.11.2344
– volume: 373
  start-page: 1861
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib16
  article-title: Global project on anti-tuberculosis drug resistance, epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the global project on anti-tuberculosis drug resistance surveillance
  publication-title: Lancet
  doi: 10.1016/S0140-6736(09)60331-7
– volume: 68
  start-page: 45
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib42
  article-title: The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape: an in-vitro study
  publication-title: J. Hosp. Infect.
  doi: 10.1016/j.jhin.2007.10.009
– volume: 10
  start-page: 657
  year: 2000
  ident: 10.1016/j.ejmech.2013.10.044_bib46
  article-title: Isoniazid-related copper(II) and nickel(II) complexes with antimycobacterial in vitro activity. Part 9
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/S0960-894X(00)00058-5
– volume: 257
  start-page: 1055
  year: 1992
  ident: 10.1016/j.ejmech.2013.10.044_bib3
  article-title: Tuberculosis: commentary on a reemergent killer
  publication-title: Science
  doi: 10.1126/science.257.5073.1055
– volume: 49
  start-page: 6790
  year: 2010
  ident: 10.1016/j.ejmech.2013.10.044_bib34
  article-title: Expanding monomeric pyrophosphate complexes beyond platinum
  publication-title: Inorg. Chem.
  doi: 10.1021/ic1006007
– volume: 98
  start-page: 5752
  year: 2001
  ident: 10.1016/j.ejmech.2013.10.044_bib36
  article-title: Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha/beta
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.091096998
– volume: 133
  start-page: 2076
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib8
  article-title: Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja109665t
– volume: 64
  start-page: 993
  year: 2012
  ident: 10.1016/j.ejmech.2013.10.044_bib29
  article-title: Redox activation of metal-based prodrugs as a strategy for drug delivery
  publication-title: Adv. Drug Delivery Rev.
  doi: 10.1016/j.addr.2012.01.007
– volume: 328
  start-page: 862
  year: 2010
  ident: 10.1016/j.ejmech.2013.10.044_bib7
  article-title: That was then but this is now: malaria research in the time of an eradication agenda
  publication-title: Science
  doi: 10.1126/science.1184785
– volume: 11
  start-page: 301
  year: 2001
  ident: 10.1016/j.ejmech.2013.10.044_bib47
  article-title: Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/S0960-894X(00)00648-X
– volume: 4
  start-page: 609
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib35
  article-title: Identification of a copper-binding metallothionein in pathogenic mycobacteria
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.109
– volume: 9
  start-page: 2996
  year: 2004
  ident: 10.1016/j.ejmech.2013.10.044_bib58
  article-title: Metal ion transport and regulation in Mycobacterium tuberculosis
  publication-title: Front. Biosci. J. Virtual Libr.
  doi: 10.2741/1454
– volume: 328
  start-page: 841
  year: 2010
  ident: 10.1016/j.ejmech.2013.10.044_bib1
  article-title: Tuberculosis & malaria. Landscapes of infection. Introduction
  publication-title: Science
  doi: 10.1126/science.328.5980.841
– volume: 15
  start-page: 1052
  year: 2010
  ident: 10.1016/j.ejmech.2013.10.044_bib5
  article-title: Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa
  publication-title: Trop. Med. Int. Health
  doi: 10.1111/j.1365-3156.2010.02581.x
– volume: 4
  start-page: 597
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib11
  article-title: Mycobacterium tuberculosis: drug resistance and future perspectives
  publication-title: Future Microbiol.
  doi: 10.2217/fmb.09.20
– volume: 103
  start-page: 1254
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib32
  article-title: Pyrophosphate-bridged complexes with picomolar toxicity
  publication-title: J. Inorg. Biochem.
  doi: 10.1016/j.jinorgbio.2009.07.010
– volume: 14
  start-page: 5731
  year: 2004
  ident: 10.1016/j.ejmech.2013.10.044_bib48
  article-title: In vitro advanced antimycobacterial screening of cobalt(II) and copper(II) complexes of fluorinated isonicotinoylhydrazones
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2004.09.052
– volume: 40
  start-page: 1024
  year: 2011
  ident: 10.1016/j.ejmech.2013.10.044_bib51
  article-title: Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties
  publication-title: Dalton Trans.
  doi: 10.1039/C0DT01607A
– volume: 30
  start-page: 637
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib14
  article-title: Multidrug-resistant and extensively drug-resistant tuberculosis in the West. Europe and United States: epidemiology, surveillance, and control
  publication-title: Clin. Chest Med.
  doi: 10.1016/j.ccm.2009.08.015
– volume: 324
  start-page: 801
  year: 2009
  ident: 10.1016/j.ejmech.2013.10.044_bib24
  article-title: Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
  publication-title: Science
  doi: 10.1126/science.1171583
– volume: 362
  start-page: 1858
  year: 2003
  ident: 10.1016/j.ejmech.2013.10.044_bib12
  article-title: Effect of multidrug resistance on global tuberculosis control
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)14918-5
– volume: 221
  start-page: 363
  year: 1994
  ident: 10.1016/j.ejmech.2013.10.044_bib44
  article-title: The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1994.tb18748.x
– volume: 13
  start-page: 309
  year: 2007
  ident: 10.1016/j.ejmech.2013.10.044_bib22
  article-title: Tuberculosis, a neglected opportunity?
  publication-title: Nat. Med.
  doi: 10.1038/nm0307-309
– volume: 64
  start-page: M83
  year: 2008
  ident: 10.1016/j.ejmech.2013.10.044_bib38
  article-title: Hydrogen-bonding and pi-pi stacking interactions in apuachloridobis(1,10-phenanthroline)cobalt(II) chloride dichloridobis(1,10-phenanthroline)cobalt(II) hexahydrate
  publication-title: Acta Crystallogr. C
  doi: 10.1107/S0108270107064803
– volume: 92
  start-page: 202
  year: 2012
  ident: 10.1016/j.ejmech.2013.10.044_bib55
  article-title: Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2011.12.006
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Snippet Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are...
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SubjectTerms Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteriocidal
Cobalt
Cobalt - chemistry
Copper
Copper - chemistry
Diphosphates - chemistry
Dose-Response Relationship, Drug
MDR-TB
Microbial Sensitivity Tests
Models, Molecular
Mycobacterium - drug effects
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Pyrophosphate
Structure-Activity Relationship
Title Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacterium tuberculosis
URI https://dx.doi.org/10.1016/j.ejmech.2013.10.044
https://www.ncbi.nlm.nih.gov/pubmed/24211634
https://www.proquest.com/docview/1466372532
Volume 70
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