Reduced immunity in lysogens of bacteriophage λ due to a mutation in the prophage
The presence of a certain mutation located near the right-hand end of the c I region in a λ prophage causes the lysogen to show reduced immunity interpreted as due to a low amount of repressor present. Aspects of reduced immunity are: Killing of the lysogenic cell by superinfection with c I mutants,...
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| Published in | Virology (New York, N.Y.) Vol. 42; no. 3; pp. 707 - 716 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.11.1970
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0042-6822 1096-0341 |
| DOI | 10.1016/0042-6822(70)90316-8 |
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| Abstract | The presence of a certain mutation located near the right-hand end of the c
I region in a λ prophage causes the lysogen to show reduced immunity interpreted as due to a low amount of repressor present. Aspects of reduced immunity are: Killing of the lysogenic cell by superinfection with c
I
mutants, with different efficiency for different mutants; formation of plaques on the lysogen by some λ mutants, among them v
3 operator mutants; high levels of spontaneously released phage also from a rec
− strain; nonexclusion of T4
rII; ability of N
−i
434 and O
−i
434 mutants to form plaques on the lysogen. The reduced immunity allele is recessive in double lysogens and in superinfection experiments. The reduced immunity lysogens are stable against spontaneous curing. They release phages which are fully subject to immunity and lysogenize well. In some bacterial strains, lysogens exist in two distinct phases stable for many generations showing different reductions of immunity. |
|---|---|
| AbstractList | The presence of a certain mutation located near the right-hand end of the c
I region in a λ prophage causes the lysogen to show reduced immunity interpreted as due to a low amount of repressor present. Aspects of reduced immunity are: Killing of the lysogenic cell by superinfection with c
I
mutants, with different efficiency for different mutants; formation of plaques on the lysogen by some λ mutants, among them v
3 operator mutants; high levels of spontaneously released phage also from a rec
− strain; nonexclusion of T4
rII; ability of N
−i
434 and O
−i
434 mutants to form plaques on the lysogen. The reduced immunity allele is recessive in double lysogens and in superinfection experiments. The reduced immunity lysogens are stable against spontaneous curing. They release phages which are fully subject to immunity and lysogenize well. In some bacterial strains, lysogens exist in two distinct phases stable for many generations showing different reductions of immunity. |
| Author | Strack, Hans B. Holder, Suse Kayser, Marianne |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4921686$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0022-2836(61)80053-3 10.1038/222541a0 10.1016/S0022-2836(67)80033-0 10.1126/science.158.3808.1588 10.1016/0042-6822(57)90022-3 10.1016/0042-6822(61)90128-3 10.1016/0042-6822(66)90212-1 10.1093/genetics/41.5.743 10.1016/0042-6822(66)90098-5 10.1146/annurev.ge.02.120168.001513 |
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I region in a λ prophage causes the lysogen to show reduced immunity interpreted as... |
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| SubjectTerms | Chromosome Mapping Coliphages - growth & development Coliphages - immunology Coliphages - isolation & purification Crosses, Genetic Culture Media Escherichia coli - growth & development Genes Genetics, Microbial Lysogeny Mutation Peptones Trypsin Virus Replication |
| Title | Reduced immunity in lysogens of bacteriophage λ due to a mutation in the prophage |
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